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NTG1 bifunctional N-glycosylase/AP lyase NTG1 [ Saccharomyces cerevisiae S288c ]

Gene ID: 851218, updated on 6-Jul-2014
Gene symbol
NTG1
Gene description
bifunctional N-glycosylase/AP lyase NTG1
Primary source
SGD:S000000013
Locus tag
YAL015C
Gene type
protein coding
RNA name
bifunctional N-glycosylase/AP lyase NTG1
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FUN33; ogg2; SCR1
See NTG1 in MapViewer
Location:
chromosome: I
Exon count :
1
Sequence:
Chromosome: I; NC_001133.9 (126903..128102, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Psk1p Neighboring gene Tpd3p Neighboring gene Syn8p Neighboring gene Dep1p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GO

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-(apurinic or apyrimidinic site) lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-(apurinic or apyrimidinic site) lyase activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
oxidized purine nucleobase lesion DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
DNA catabolic process, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
base-excision repair IDA
Inferred from Direct Assay
more info
PubMed 
base-excision repair IEA
Inferred from Electronic Annotation
more info
 
base-excision repair, AP site formation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
bifunctional N-glycosylase/AP lyase NTG1
NP_009387.1
  • DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 

    Range
    126903..128102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178160.1NP_009387.1  bifunctional N-glycosylase/AP lyase NTG1 [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_009387.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P31378
    Conserved Domains (2) summary
    COG0177
    Location:140318
    Blast Score: 541
    Nth; Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]
    cd00056
    Location:145310
    Blast Score: 356
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases

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