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URA4 dihydroorotase [ Saccharomyces cerevisiae S288c ]

Gene ID: 851139, updated on 3-Jul-2016
Gene symbol
URA4
Gene description
dihydroorotase
Primary source
SGD:S000004412
Locus tag
YLR420W
Gene type
protein coding
RNA name
dihydroorotase
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See URA4 in Map Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (963785..964879)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene putative helicase Neighboring gene tRNA Neighboring gene proteasome regulatory particle lid subunit RPN13 Neighboring gene Dck1p

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
dihydroorotase activity IEA
Inferred from Electronic Annotation
more info
 
dihydroorotase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
dihydroorotase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
'de novo' pyrimidine nucleobase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
pyrimidine nucleotide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Names
dihydroorotase
NP_013524.1
  • Dihydroorotase; catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    963785..964879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182308.1NP_013524.1  dihydroorotase [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_013524.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P20051
    Conserved Domains (1) summary
    cd01294
    Location:5357
    DHOase; Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is ...