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RSC2 Rsc2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851071, updated on 13-Apr-2024

Summary

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Gene symbol
RSC2
Gene description
Rsc2p
Primary source
SGD:S000004349
Locus tag
YLR357W
See related
AllianceGenome:SGD:S000004349
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables chromatin binding activity. Involved in DNA repair; chromosome organization; and transcription elongation from RNA polymerase II promoter. Part of RSC-type complex. Human ortholog(s) of this gene implicated in extrahepatic bile duct adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (841331..844000)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ketol-acid reductoisomerase Neighboring gene Atg33p Neighboring gene uncharacterized protein Neighboring gene adenylosuccinase ADE13 Neighboring gene Vps38p Neighboring gene phosphoprotein phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A role for chromatin remodellers in replication of damaged DNA. Niimi A, et al. Nucleic Acids Res, 2012 Aug. PMID 22638582, Free PMC Article
  2. Concurrent fast and slow cycling of a transcriptional activator at an endogenous promoter. Karpova TS, et al. Science, 2008 Jan 25. PMID 18218898
  3. Functional differences between RSC1 and RSC2, components of a for growth essential chromatin-remodeling complex of Saccharomyces cerevisiae, during the sporulation process. Yukawa M, et al. FEMS Yeast Res, 2002 May. PMID 12702296
  4. RSC2, encoding a component of the RSC nucleosome remodeling complex, is essential for 2 microm plasmid maintenance in Saccharomyces cerevisiae. Wong MC, et al. Mol Cell Biol, 2002 Jun. PMID 12024034, Free PMC Article
  5. Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex. Ng HH, et al. Genes Dev, 2002 Apr 1. PMID 11937489, Free PMC Article

See all (150) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes.
    Title: Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes.
  2. Results show that H4 acetylation by the NuA4 complex and RSC2 are both required for gap-induced sister chromatid recombination.
    Title: NuA4 initiates dynamic histone H4 acetylation to promote high-fidelity sister chromatid recombination at postreplication gaps.
  3. This study uncovered a direct interaction between the Rsc2 BAH domain and histone H3 and led to the identification of an interaction interface that is conserved in a subset of Rsc-like BAH domains.
    Title: The BAH domain of Rsc2 is a histone H3 binding domain.
  4. Data show that RSC1 and RSC2 are haploinsufficient for spore formation in a smk1 hypomorph.
    Title: RSC1 and RSC2 are required for expression of mid-late sporulation-specific genes in Saccharomyces cerevisiae.
  5. RSC2 may function through the tRNA element to restric the spread of silencing
    Title: Multiple bromodomain genes are involved in restricting the spread of heterochromatic silencing at the Saccharomyces cerevisiae HMR-tRNA boundary.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UV-damage excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in nucleosome disassembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RSC-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RSC-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RSC-type complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rsc2p
NP_013461.1
  • Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance; RSC2 has a paralog, RSC1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    841331..844000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182246.1 → NP_013461.1  TPA: Rsc2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013461.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYZ5, Q06488
    UniProtKB/TrEMBL
    A0A6A5PTQ6, A7A1N5, C7GRY2, C8ZDW4, G2WJH5, N1P028
    Conserved Domains (2) summary
    cd05521
    Location:17 → 121
    Bromo_Rsc1_2_I; Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two ...
    COG5076
    Location:123 → 503
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6K15_L.1
6KW3_L.1
6KW4_L.1
6KW5_L.1
6V8O_F.1
6V92_F.1
Q06488.1

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