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HSP60 chaperone ATPase HSP60 [ Saccharomyces cerevisiae S288c ]

Gene ID: 850963, updated on 3-Jul-2016
Gene symbol
HSP60
Gene description
chaperone ATPase HSP60
Primary source
SGD:S000004249
Locus tag
YLR259C
Gene type
protein coding
RNA name
chaperone ATPase HSP60
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CPN60; MIF4; MNA2
See HSP60 in Map Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (663284..665002, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene glycogen (starch) synthase GSY2 Neighboring gene sphinganine kinase LCB5 Neighboring gene Vps63p Neighboring gene Rab family GTPase YPT6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Mitochondrial protein import, organism-specific biosystem (from REACTOME)
    Mitochondrial protein import, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication origin binding IDA
Inferred from Direct Assay
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
'de novo' protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
chaperone-mediated protein complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein folding IEA
Inferred from Electronic Annotation
more info
 
protein import into mitochondrial intermembrane space IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
protein refolding IEA
Inferred from Electronic Annotation
more info
 
protein refolding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Names
chaperone ATPase HSP60
NP_013360.1
  • Tetradecameric mitochondrial chaperonin; required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    663284..665002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182146.1NP_013360.1  chaperone ATPase HSP60 [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_013360.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P19882
    Conserved Domains (2) summary
    PRK12850
    Location:25548
    groEL; chaperonin GroEL; Reviewed
    cd03344
    Location:25548
    GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...