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CDD1 cytidine deaminase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850946, updated on 13-Apr-2024

Summary

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Gene symbol
CDD1
Gene description
cytidine deaminase
Primary source
SGD:S000004235
Locus tag
YLR245C
See related
AllianceGenome:SGD:S000004235
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cytidine deaminase activity. Involved in cytidine catabolic process; deoxycytidine catabolic process; and pyrimidine-containing compound salvage. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (626502..626930, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene putative signal sequence-binding GTPase GPN3 Neighboring gene methionine aminopeptidase MAP1 Neighboring gene palmitoyltransferase ERF2 Neighboring gene tRNA-Leu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of a Schizosaccharomyces pombe gene which in high copy confers resistance to the nucleoside analogue 5-azacytidine. Platt GM, et al. Yeast, 1997 Apr. PMID 9153756
  2. Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase. Dance GS, et al. Nucleic Acids Res, 2001 Apr 15. PMID 11292850, Free PMC Article
  3. The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1. Xie K, et al. Proc Natl Acad Sci U S A, 2004 May 25. PMID 15148397, Free PMC Article
  4. New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism. Kurtz JE, et al. Curr Genet, 1999 Sep. PMID 10501935
  5. Integrative proteomics and biochemical analyses define Ptc6p as the Saccharomyces cerevisiae pyruvate dehydrogenase phosphatase. Guo X, et al. J Biol Chem, 2017 Jul 14. PMID 28539364, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cytidine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytidine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytidine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables deoxycytidine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytidine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytidine deamination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytidine deamination IEA
Inferred from Electronic Annotation
more info
  
involved_in deoxycytidine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyrimidine-containing compound salvage IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytidine deaminase
NP_013346.1
  • Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    626502..626930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182132.1 → NP_013346.1  TPA: cytidine deaminase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013346.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYP3, Q06549
    UniProtKB/TrEMBL
    A0A6A5PVE8, A7A1C8, B3RHD0, C7GQZ1, C8ZDK8, G2WJ71, N1P6X7
    Conserved Domains (1) summary
    TIGR01354
    Location:12 → 141
    cyt_deam_tetra; cytidine deaminase, homotetrameric
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06549.1

Gene LinkOut

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