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ATG38 Atg38p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850908, updated on 13-Apr-2024

Summary

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Gene symbol
ATG38
Gene description
Atg38p
Primary source
SGD:S000004201
Locus tag
YLR211C
See related
AllianceGenome:SGD:S000004201
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables structural molecule activity. Involved in macroautophagy. Located in phagophore assembly site and vacuolar membrane. Part of phosphatidylinositol 3-kinase complex, class III, type I. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
2
Sequence:
Chromosome: XII; NC_001144.5 (563792..564531, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene purine-nucleoside phosphorylase Neighboring gene B-type cyclin CLB4 Neighboring gene gamma-tubulin Neighboring gene putative glycosylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex. Ohashi Y, et al. Autophagy, 2016 Nov. PMID 27630019, Free PMC Article
  2. Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. Araki Y, et al. J Cell Biol, 2013 Oct 28. PMID 24165940, Free PMC Article
  3. Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation. Schreiber A, et al. Mol Cell, 2021 Dec 16. PMID 34798055, Free PMC Article
  4. DeepPhagy: a deep learning framework for quantitatively measuring autophagy activity in Saccharomyces cerevisiae. Zhang Y, et al. Autophagy, 2020 Apr. PMID 31204567, Free PMC Article
  5. Selective defects in gene expression control genome instability in yeast splicing mutants. Tam AS, et al. Mol Biol Cell, 2019 Jan 15. PMID 30462576, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural molecule activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  
part_of phosphatidylinositol 3-kinase complex, class III, type I IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuolar membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Atg38p
NP_013312.2
  • Homodimeric subunit of autophagy-specific PtdIns-3-kinase complex I; required for the integrity of the active PtdIns-3-kinase complex I by maintaining an association between Vps15p-Vps34p and Atg14p-Vps30p subcomplexes; localizes to the pre-autophagosomal structure (PAS) in an Atg14p-dependent manner; ATG38 is non-essential but is required for macroautophagy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    563792..564531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182098.1 → NP_013312.2  TPA: Atg38p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013312.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYL2, Q05789
    UniProtKB/TrEMBL
    A7A199, B3RHA0, C7GIU0, C8ZDH5, G2WJ41, N1NYE2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05789.2

Gene LinkOut

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