HCR1 Hcr1p [ Saccharomyces cerevisiae S288c ]

Gene ID: 850889, updated on 21-Jan-2012

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Summary

Gene symbol: HCR1
Gene description: Hcr1p
Primary source: SGD:S000004182
Locus tag: YLR192C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Saccharomyces cerevisiae S288c (strain: S288c)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

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Genomic context

Sequence :: Chromosome: XII; NC_001144.5 (538792..539589, complement)

See HCR1 in MapViewer

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that the eIF3b-eIF3j/eIF3a module binds near the mRNA entry channel and regulates the transition between scanning-conducive and initiation-competent conformations of the preinitiation complex.
Title: The C-terminal region of eukaryotic translation initiation factor 3a (eIF3a) promotes mRNA recruitment, scanning, and, together with eIF3j and the eIF3b RNA recognition motif, selection of AUG start codons.
although the Fe-S cluster is not required for the interaction of Rli1 with eRF1 or its other interacting partner, Hcr1, from the initiation complex eIF3, it is required for its activity in translation termination
Title: The iron-sulphur protein RNase L inhibitor functions in translation termination.
eIF3j/HCR1 remains associated with the scanning preinitiation complexes and does not dissociate from the small ribosomal subunit upon mRNA recruitment, as previously believed
Title: The indispensable N-terminal half of eIF3j/HCR1 cooperates with its structurally conserved binding partner eIF3b/PRT1-RRM and with eIF1A in stringent AUG selection.
Interaction of the RNP1 motif with HCR1 promotes 40S binding of eIF3.
Title: Interaction of the RNP1 motif in PRT1 with HCR1 promotes 40S binding of eukaryotic initiation factor 3 in yeast.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
NP_013293.1	NP_015006.1	PRT1	BIND	PubMed	Hcr1 interacts with Prt1.
NP_013293.1	NP_010376.1	RLI1	BIND	PubMed	Rli1 interacts with Hcr1.
NP_013293.1	NP_009635.1	RPG1	BIND	PubMed	Hcr1 interacts with Rpg1 (Tif32).
BioGRID:31462	BioGRID:33145	ARC1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:32159	ARX1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:33340	ASK10	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:33074	ATG1	BioGRID	PubMed	Biochemical Activity
BioGRID:31462	BioGRID:36231	BRR1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:34325	BRX1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:35563	CAF120	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:36005	CBC2	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:31825	CDC13	BioGRID	PubMed	Synthetic Rescue
BioGRID:31462	BioGRID:31676	CDC73	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:35197	CSI1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:33335	DBF2	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:33172	DBP3	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:33988	DBR1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:36448	DED81	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:31148	DEG1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:35061	DUS1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:36712	EAF5	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:35690	EAF7	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:36716	EDC3	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:34635	ESA1	BioGRID	PubMed	Biochemical Activity
BioGRID:31462	BioGRID:33773	ESS1	BioGRID	PubMed	Protein-peptide
BioGRID:31462	BioGRID:35691	FPR1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:31730	FUN12	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31462	BioGRID:32682	FUS3	BioGRID	PubMed	Biochemical Activity
BioGRID:31462	BioGRID:36491	FYV4	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:36759	GCD11	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:32823	GRS1	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:33831	HOC1	BioGRID	PubMed	Synthetic Lethality
BioGRID:31462	BioGRID:35923	HSP82	BioGRID	PubMed	Synthetic Lethality
BioGRID:31462	BioGRID:34392	HTZ1	BioGRID	PubMed	Phenotypic Suppression; Positive Genetic
BioGRID:31462	BioGRID:35976	IPL1	BioGRID	PubMed	Biochemical Activity
BioGRID:31462	BioGRID:34996	IST3	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:33845	JSN1	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:36056	KAP120	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:31610	KAP95	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:30927	KRR1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:31149	LOC1	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:32495	LRS4	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:33632	LSM1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:33993	LTV1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:32058	MAF1	BioGRID	PubMed	Synthetic Growth Defect
BioGRID:31462	BioGRID:34395	MDM12	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:31343	MEF1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:36014	MEX67	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:36811	MOT2	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:33183	MRH4	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:35160	MRPL39	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:34123	MRT4	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:33129	NAB2	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:31462	BioGRID:35489	NIP1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:31462	BioGRID:33887	NMD5	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:32040	NOP1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:34361	NOP12	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:35715	NOP15	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:36732	NOP16	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:34876	NUP159	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:33364	NUP57	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:31052	PAT1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:33319	PEX8	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:34009	PGM1	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:32867	POP7	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:32680	POP8	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:34120	PRP40	BioGRID	PubMed	Protein-peptide
BioGRID:31462	BioGRID:34746	PRT1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Dosage Rescue; Reconstituted Complex; Synthetic Growth Defect
BioGRID:31462	BioGRID:31053	PTC6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31462	BioGRID:32642	PTH2	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:34634	PUS7	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:31315	RIC1	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:32148	RLI1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Positive Genetic; Two-hybrid
BioGRID:31462	BioGRID:33617	RPB4	BioGRID	PubMed	Affinity Capture-Western; Dosage Growth Defect; Synthetic Growth Defect; Two-hybrid
BioGRID:31462	BioGRID:32464	RPB7	BioGRID	PubMed	Affinity Capture-Western; Dosage Growth Defect
BioGRID:31462	BioGRID:32781	RPG1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Dosage Rescue; Reconstituted Complex; Synthetic Growth Defect
BioGRID:31462	BioGRID:31189	RPL29	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:36634	RPN10	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:31152	RPN11	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31462	BioGRID:31014	RPS14A	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:32505	RPS18A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31462	BioGRID:33128	RPS2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:31462	BioGRID:33363	RPS23A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:31462	BioGRID:36637	RPS4B	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:32629	RPS8A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31462	BioGRID:36848	RPS8B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31462	BioGRID:34283	RRI2	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:30952	RRP7	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:36869	RSP5	BioGRID	PubMed	Protein-peptide
BioGRID:31462	BioGRID:32210	SAC3	BioGRID	PubMed	Phenotypic Suppression; Positive Genetic
BioGRID:31462	BioGRID:35441	SAP30	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:32420	SEM1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:31689	SEN1	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:35234	SEN15	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:31378	SEN2	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:33591	SET2	BioGRID	PubMed	Protein-peptide
BioGRID:31462	BioGRID:34437	SHE4	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:32692	SLA1	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:31543	SMD2	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:32561	SMT3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31462	BioGRID:32529	SNF1	BioGRID	PubMed	Biochemical Activity
BioGRID:31462	BioGRID:33136	SNF4	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:36267	SNT309	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:32059	SOK1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31462	BioGRID:34223	SRP40	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:36498	SSF1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:35302	STO1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:35595	SUI1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:31462	BioGRID:33763	SUI2	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:32225	SUP35	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:36123	SUR1	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:32874	SWD3	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:33377	SYF2	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:35414	TAF9	BioGRID	PubMed	Synthetic Lethality
BioGRID:31462	BioGRID:34051	TEF4	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:35438	TIF11	BioGRID	PubMed	Dosage Rescue
BioGRID:31462	BioGRID:35322	TIF34	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation
BioGRID:31462	BioGRID:32487	TIF35	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
BioGRID:31462	BioGRID:36218	TIF5	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:31462	BioGRID:35447	TMA23	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:34398	TOP1	BioGRID	PubMed	Positive Genetic
BioGRID:31462	BioGRID:33595	TPK1	BioGRID	PubMed	Biochemical Activity
BioGRID:31462	BioGRID:34187	TRM2	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:32216	TRM82	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:36319	URN1	BioGRID	PubMed	Protein-peptide
BioGRID:31462	BioGRID:33348	VMA21	BioGRID	PubMed	Synthetic Growth Defect
BioGRID:31462	BioGRID:33349	VOA1	BioGRID	PubMed	Synthetic Growth Defect
BioGRID:31462	BioGRID:31137	WWM1	BioGRID	PubMed	Protein-peptide
BioGRID:31462	BioGRID:32599	YBL104C	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:36568	YCK1	BioGRID	PubMed	Biochemical Activity
BioGRID:31462	BioGRID:33600	YJL160C	BioGRID	PubMed	Negative Genetic
BioGRID:31462	BioGRID:31529	YPT6	BioGRID	PubMed	Negative Genetic

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General gene information

Pathways from BioSystems

Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
Cap-dependent Translation Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystem (from REACTOME)
Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA transport, organism-specific biosystem (from KEGG)
RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
RNA transport, conserved biosystem (from KEGG)
RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
Ribosomal scanning and start codon recognition, organism-specific biosystem (from REACTOME)
Ribosomal scanning and start codon recognition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translation, organism-specific biosystem (from REACTOME)
Translation, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
translation initiation factor activity	IEA Inferred from Electronic Annotation more info
translation initiation factor activity	IPI Inferred from Physical Interaction more info	PubMed
translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
cytoplasmic translation	IPI Inferred from Physical Interaction more info	PubMed
cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
translation	IEA Inferred from Electronic Annotation more info
translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
eukaryotic translation initiation factor 3 complex	IPI Inferred from Physical Interaction more info	PubMed

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General protein information

Names: Hcr1p

NP_013293.1

Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5

Range

538792..539589, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182079.1 → NP_013293.1 Hcr1p [Saccharomyces cerevisiae S288c]

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q05775

Conserved Domains (1) summary

pfam08597
Location:2 – 214
Blast Score: 345

eIF3_subunit; Translation initiation factor eIF3 subunit