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    MSL5 Msl5p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 850807, updated on 8-Jan-2012
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    Summary

    Gene symbol
    MSL5
    Gene description
    Msl5p
    Primary source
    SGD:S000004106
    Locus tag
    YLR116W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Sequence :
    Chromosome: XII; NC_001144.5 (380822..382252)
    See MSL5 in MapViewer

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Avl9p Neighboring gene Cft2p Neighboring gene Clf1p Neighboring gene hypothetical protein

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. Hoppins S, et al. J Cell Biol, 2011 Oct 17. PMID 21987634.
    2. Composition of yeast snRNPs and snoRNPs in the absence of trimethylguanosine caps reveals nuclear cap binding protein as a gained U1 component implicated in the cold-sensitivity of tgs1Δ cells. Schwer B, et al. Nucleic Acids Res, 2011 Aug. PMID 21558325.
    3. Saccharomyces cerevisiae Gis2 interacts with the translation machinery and is orthogonal to myotonic dystrophy type 2 protein ZNF9. Sammons MA, et al. Biochem Biophys Res Commun, 2011 Mar 4. PMID 21277287.
    4. Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes. Ash MR, et al. Structure, 2010 Aug 11. PMID 20696395.
    5. A global protein kinase and phosphatase interaction network in yeast. Breitkreutz A, et al. Science, 2010 May 21. PMID 20489023.

    See all (22) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. a conserved zinc knuckle of the branch point-binding protein plays a different role in RNA processing than enhancing the binding of branch point-binding protein to the branch point sequence
      Title: An extended RNA binding site for the yeast branch point-binding protein and the role of its zinc knuckle domains in RNA binding.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_013217.1 NC_001146.3 DBP2    BIND  PubMed Bbp interacts with DBP2 gene. 
    NP_013217.1 NC_001134.7 ECM33    BIND  PubMed Bbp interacts with ECM33 gene. 
    NP_013217.1 NP_012849.1 MUD2    BIND  PubMed The pre-mRNA splicing factors Msl5p and Mud2p interact. 
    NP_013217.1 NC_001147.4 PDR5    BIND  PubMed Bbp interacts with PDR5 gene. 
    NP_013217.1 NP_012913.1 PRP40    BIND  PubMed The pre-mRNA splicing factors Msl5 and Prp40 interact. 
    NP_013217.1 NC_001136.6 SAC6    BIND  PubMed Bbp interacts with SAC6 gene. 
    BioGRID:31388 BioGRID:33800 ANB1    BioGRID  PubMed Positive Genetic 
    BioGRID:31388 BioGRID:33761 APL1    BioGRID  PubMed Two-hybrid 
    BioGRID:31388 BioGRID:34861 ASG1    BioGRID  PubMed Two-hybrid 
    BioGRID:31388 BioGRID:34441 CKB2    BioGRID  PubMed Negative Genetic 
    BioGRID:31388 BioGRID:31902 ENT1    BioGRID  PubMed Two-hybrid 
    BioGRID:31388 BioGRID:35584 GIS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31388 BioGRID:32665 HEK2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:31388 BioGRID:35240 KAR5    BioGRID  PubMed Two-hybrid 
    BioGRID:31388 BioGRID:35626 MER1    BioGRID  PubMed Two-hybrid 
    BioGRID:31388 BioGRID:33830 MOG1    BioGRID  PubMed Negative Genetic 
    BioGRID:31388 BioGRID:36077 MSD1    BioGRID  PubMed Negative Genetic 
    BioGRID:31388 BioGRID:32821 MUD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31388 BioGRID:34057 MUD2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Phenotypic Enhancement; Phenotypic Suppression; Reconstituted Complex; Two-hybrid 
    BioGRID:31388 BioGRID:35256 NAM7    BioGRID  PubMed Synthetic Lethality 
    BioGRID:31388 BioGRID:32489 NPL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31388 BioGRID:35445 PPA2    BioGRID  PubMed Positive Genetic 
    BioGRID:31388 BioGRID:36745 PRP22    BioGRID  PubMed Two-hybrid 
    BioGRID:31388 BioGRID:35122 PRP39    BioGRID  PubMed Two-hybrid 
    BioGRID:31388 BioGRID:34120 PRP40    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:31388 BioGRID:34404 RRP6    BioGRID  PubMed Negative Genetic 
    BioGRID:31388 BioGRID:32342 RTT103    BioGRID  PubMed Positive Genetic 
    BioGRID:31388 BioGRID:35394 SKY1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31388 BioGRID:32872 SMY2    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:31388 BioGRID:31977 SUB2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:31388 BioGRID:36161 SWI1    BioGRID  PubMed Two-hybrid 
    BioGRID:31388 BioGRID:36076 SYH1    BioGRID  PubMed Two-hybrid 
    BioGRID:31388 BioGRID:33823 TOR1    BioGRID  PubMed Two-hybrid 
    BioGRID:31388 BioGRID:35636 WHI3    BioGRID  PubMed Protein-RNA 
    BioGRID:31388 BioGRID:31907 YDL156W    BioGRID  PubMed Two-hybrid 
    BioGRID:31388 BioGRID:31529 YPT6    BioGRID  PubMed Negative Genetic 
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    General gene information

    Homology

    • Homologs of the MSL5 gene: The MSL5 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, and rice.

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    pre-mRNA branch point binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    commitment complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Msl5p
    NP_013217.1
    • Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5

      Range
      380822..382252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182003.1 → NP_013217.1  Msl5p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q12186
      Conserved Domains (3) summary
      cd02395
      Location:149 – 267
      Blast Score: 311
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      COG5082
      Location:267 – 367
      Blast Score: 261
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
      COG5176
      Location:1 – 269
      Blast Score: 927
      MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006945.2 DAA09430.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q12186.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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