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    TEN1 Ten1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 850696, updated on 21-May-2012
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    Summary

    Gene symbol
    TEN1
    Gene description
    Ten1p
    Primary source
    SGD:S000004000
    Locus tag
    YLR010C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Location :
    chromosome: XII
    Sequence :
    Chromosome: XII; NC_001144.5 (167320..167802, complement)
    See TEN1 in MapViewer

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Pam18p Neighboring gene Rlp24p Neighboring gene tRNA Neighboring gene Lot6p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Telomere capping in non-dividing yeast cells requires Yku and Rap1. Vodenicharov MD, et al. EMBO J, 2010 Sep 1. PMID 20628356.
    2. Purification and characterization of Stn1p, a single-stranded telomeric DNA binding protein. Qian W, et al. Protein Expr Purif, 2010 Oct. PMID 20576529.
    3. Structure prediction-driven genetics in Saccharomyces cerevisiae identifies an interface between the t-RPA proteins Stn1 and Ten1. Paschini M, et al. Genetics, 2010 May. PMID 20157006.
    4. TEN1 is essential for CDC13-mediated telomere capping. Xu L, et al. Genetics, 2009 Nov. PMID 19752213.
    5. Ten1p promotes the telomeric DNA-binding activity of Cdc13p: implication for its function in telomere length regulation. Qian W, et al. Cell Res, 2009 Jul. PMID 19532124.

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Results emphasize that Cdc13 relies on Ten1 to execute its essential function, but leave open the possibility that Ten1 has a Cdc13-independent role in DNA replication.
      Title: TEN1 is essential for CDC13-mediated telomere capping.
    2. Ten1 protein interacts with Cdc13 protein to promote its telemeric TG(1-3) DNA-binding activity.
      Title: Ten1p promotes the telomeric DNA-binding activity of Cdc13p: implication for its function in telomere length regulation.
    3. Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates.
      Title: RPA-like proteins mediate yeast telomere function.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_013110.1 NP_010061.1 CDC13    BIND  PubMed Cdc13 interacts with Ten1. 
    NP_013110.1 NP_010367.1 STN1    BIND  PubMed Stn1 interacts with Ten1. 
    BioGRID:31283 BioGRID:36540 CDC12    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31283 BioGRID:31825 CDC13    BioGRID  PubMed Affinity Capture-Western; Dosage Rescue; Phenotypic Enhancement; Reconstituted Complex; Synthetic Lethality; Two-hybrid 
    BioGRID:31283 BioGRID:31582 EST2    BioGRID  PubMed Synthetic Lethality 
    BioGRID:31283 BioGRID:34435 EXO1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:31283 BioGRID:35721 POL1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31283 BioGRID:32138 STN1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Dosage Rescue; Phenotypic Suppression; Reconstituted Complex; Synthetic Rescue; Two-hybrid 
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    General gene information

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    negative regulation of telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    telomere capping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    telomere capping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    telomere maintenance via telomerase IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear telomere cap complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Ten1p
    NP_013110.1
    • Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5

      Range
      167320..167802, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181897.1 → NP_013110.1  Ten1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q07921
      Conserved Domains (1) summary
      pfam12658
      Location:2 – 147
      Blast Score: 182
      Ten1; Telomere capping
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006945.2 DAA09328.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07921.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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