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FPS1 Fps1p [ Saccharomyces cerevisiae S288c ]

Gene ID: 850683, updated on 27-Aug-2016
Gene symbol
FPS1
Gene description
Fps1p
Primary source
SGD:S000003966
Locus tag
YLL043W
Gene type
protein coding
RNA name
Fps1p
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See FPS1 in Map Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (49938..51947)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Rnp1p Neighboring gene ribosomal 60S subunit protein L8B Neighboring gene E2-like conjugating enzyme Neighboring gene succinate dehydrogenase iron-sulfur protein subunit SDH2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GO

Function Evidence Code Pubs
glycerol channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycerol transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
transporter activity IEA
Inferred from Electronic Annotation
more info
 
transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
water channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acetate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
arsenite transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular water homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycerol transport IDA
Inferred from Direct Assay
more info
PubMed 
glycerol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
polyol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to arsenic-containing substance IGI
Inferred from Genetic Interaction
more info
PubMed 
response to arsenic-containing substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
fungal-type vacuole IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane ISM
Inferred from Sequence Model
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Names
Fps1p
NP_013057.1
  • Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; role in mediating passive diffusion of glycerol is key factor in maintenance of redox balance; phosphorylated by Hog1p MAPK under acetate stress; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which themselves are regulated by Hog1p phosphorylation under osmotic stress

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    49938..51947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181863.1NP_013057.1  Fps1p [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_013057.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P23900
    Conserved Domains (1) summary
    cd00333
    Location:254530
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...