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HSP104 chaperone ATPase HSP104 [ Saccharomyces cerevisiae S288c ]

Gene ID: 850633, updated on 20-Nov-2014
Gene symbol
HSP104
Gene description
chaperone ATPase HSP104
Primary source
SGD:S000003949
Locus tag
YLL026W
Gene type
protein coding
RNA name
chaperone ATPase HSP104
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See HSP104 in MapViewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (88623..91349)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Tpo1p Neighboring gene Isa1p Neighboring gene tRNA Neighboring gene Pau17p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ADP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
ATPase activity, coupled IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity, coupled IMP
Inferred from Mutant Phenotype
more info
PubMed 
chaperone binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
TRC complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
chaperone ATPase HSP104
NP_013074.1
  • Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; potentiated Hsp104p variants decrease TDP-43 proteotoxicity by eliminating its cytoplasmic aggregation

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 

    Range
    88623..91349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181846.1NP_013074.1  chaperone ATPase HSP104 [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_013074.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P31539
    Conserved Domains (5) summary
    cd00009
    Location:187343
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    TIGR03346
    Location:7863
    chaperone_ClpB; ATP-dependent chaperone ClpB
    pfam02861
    Location:99149
    Clp_N; Clp amino terminal domain
    pfam10431
    Location:775857
    ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
    pfam14235
    Location:447517
    DUF4337; Domain of unknown function (DUF4337)