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    RSC8 Rsc8p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 850598, updated on 21-May-2012

    Summary

    Gene symbol
    RSC8
    Gene description
    Rsc8p
    Primary source
    SGD:S000001933
    Locus tag
    YFR037C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SWH3

    Genomic context

    Location :
    chromosome: VI
    Sequence :
    Chromosome: VI; NC_001138.5 (227513..229186, complement)
    See RSC8 in MapViewer

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene Cdc26p Neighboring gene Irc5p Neighboring gene hypothetical protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:31195 BioGRID:35247 ABF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:32812 AIM3    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:35173 AIM34    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:32891 AIM4    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:34950 APQ12    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:31358 ARP6    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:36212 ARP7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:35205 ARP9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:33639 ASF1    BioGRID  PubMed Co-localization 
    BioGRID:31195 BioGRID:34429 BUB3    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:31123 BUD27    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:36917 CHD1    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:34734 CIN1    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:34955 CKA1    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:34460 CKA2    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:33227 CKB1    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:34441 CKB2    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:35540 CLA4    BioGRID  PubMed Dosage Growth Defect 
    BioGRID:31195 BioGRID:31725 CLN3    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:34084 CSE4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:31360 CSF1    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:36302 CTF4    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:36625 CTF8    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:34479 DIA2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31195 BioGRID:35002 DSN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:36200 EAF3    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:33453 ELP2    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:36095 ELP3    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:35492 ELP6    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:32206 ENT5    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:31122 EPL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:35186 ERG5    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:35161 ERG6    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:30970 GBP2    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:33503 GCN5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:33226 GET1    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:36728 GIM4    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:35584 GIS2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:31195 BioGRID:32710 HHF1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:31195 BioGRID:35797 HHF2    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:31195 BioGRID:32711 HHT1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:31195 BioGRID:35796 HHT2    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:31195 BioGRID:34440 HIR2    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:33896 HIR3    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:32227 HMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:33063 HOS2    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:32912 HPC2    BioGRID  PubMed Co-localization 
    BioGRID:31195 BioGRID:35364 HSC82    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:34032 HSL1    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:31226 HSP104    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:31003 HTL1    BioGRID  PubMed Affinity Capture-MS; Dosage Rescue; Reconstituted Complex; Two-hybrid 
    BioGRID:31195 BioGRID:34392 HTZ1    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:31133 IES1    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:31165 IOC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:31196 IRC5    BioGRID  PubMed Dosage Rescue 
    BioGRID:31195 BioGRID:32940 ISW1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:34692 ISW2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:33119 ITC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:31610 KAP95    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:32437 LSM6    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:31002 MAK31    BioGRID  PubMed Dosage Rescue 
    BioGRID:31195 BioGRID:35532 MCK1    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:36242 MED1    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:33163 MMS2    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:36099 MOT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:34312 MSH2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:32152 MSH6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:31195 BioGRID:34552 NFI1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:32052 NHP10    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:31195 BioGRID:36227 NHP6A    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:32795 NHP6B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:35266 NPL6    BioGRID  PubMed Affinity Capture-MS; Dosage Rescue; Two-hybrid 
    BioGRID:31195 BioGRID:31790 NUP60    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:35101 ORC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:36931 PDA1    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:32130 PPH3    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:35633 PSY2    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:33788 RAD26    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:35250 RCO1    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:34602 RET1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:31793 RFA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:35527 RFA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:31447 RFX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:31315 RIC1    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:35543 RIM21    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:35829 RPC34    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:31152 RPN11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:34512 RPO31    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:31602 RPP0    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:34404 RRP6    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:33301 RSC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:31619 RSC2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:31195 BioGRID:32355 RSC3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:31195 BioGRID:36488 RSC30    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:34140 RSC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:31307 RSC58    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:31032 RSC6    BioGRID  PubMed Affinity Capture-MS; Dosage Rescue; Reconstituted Complex; Two-hybrid 
    BioGRID:31195 BioGRID:31195 RSC8    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:31195 BioGRID:35078 RSC9    BioGRID  PubMed Affinity Capture-MS; Synthetic Lethality; Two-hybrid 
    BioGRID:31195 BioGRID:34334 RTG1    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:33525 RTT102    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:35630 RTT106    BioGRID  PubMed Affinity Capture-Western; Co-localization; Negative Genetic; Reconstituted Complex 
    BioGRID:31195 BioGRID:35441 SAP30    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:33591 SET2    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:34162 SET3    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:31585 SFH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:30971 SGF29    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:33181 SGF73    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:34400 SIN3    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:31195 BioGRID:36461 SLT2    BioGRID  PubMed Dosage Growth Defect 
    BioGRID:31195 BioGRID:32561 SMT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:34678 SNF2    BioGRID  PubMed Two-hybrid 
    BioGRID:31195 BioGRID:36897 SPT15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:33049 SPT16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:33153 SRM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:30946 SRO9    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:31195 BioGRID:31786 SSA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:31882 SSB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:36075 SSE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:32498 SSN2    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:34865 STH1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Two-hybrid 
    BioGRID:31195 BioGRID:31755 SWC3    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:32926 SWC5    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:36856 SWI4    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:32391 SWR1    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:32895 TAF5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:35414 TAF9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:35971 THI6    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:36601 THP2    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:34685 TIM18    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:35056 TUB1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31195 BioGRID:35081 TUB3    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:35401 UBP8    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:32257 UME6    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:35037 URA5    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:34133 VPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31195 BioGRID:35128 VPS71    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:32537 VPS72    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:34444 WHI2    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:31907 YDL156W    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:31195 BioGRID:32506 YHP1    BioGRID  PubMed Positive Genetic 
    BioGRID:31195 BioGRID:31529 YPT6    BioGRID  PubMed Negative Genetic 
    BioGRID:31195 BioGRID:33519 YTA7    BioGRID  PubMed Affinity Capture-MS; Co-localization; Negative Genetic 

    General gene information

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA-dependent ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    RSC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Names
    Rsc8p
    NP_116695.1
    • Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5

      Range
      227513..229186, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180002.1NP_116695.1  Rsc8p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P43609
      Conserved Domains (4) summary
      cd02336
      Location:258302
      Blast Score: 211
      ZZ_RSC8; Zinc finger, ZZ type. Zinc finger present in RSC8 and related proteins. RSC8 is a component of the RSC complex, which is closely related to the SWI/SNF complex and is involved in remodeling chromatin structure. The ZZ motif coordinates a zinc ion and ...
      COG5259
      Location:32557
      Blast Score: 1550
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      pfam04433
      Location:84168
      Blast Score: 303
      SWIRM; SWIRM domain
      cl15779
      Location:312357
      Blast Score: 102
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006940.2 DAA12480.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43609.1 GenPept

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