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    PER1 Per1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 850411, updated on 5-Feb-2012
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    Summary

    Gene symbol
    PER1
    Gene description
    Per1p
    Primary source
    SGD:S000000640
    Locus tag
    YCR044C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    COS16
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    Genomic context

    Sequence :
    Chromosome: III; NC_001135.5 (206877..207950, complement)
    See PER1 in MapViewer

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Taf2p Neighboring gene hypothetical protein Neighboring gene Rrt12p Neighboring gene Img1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin. Boettner DR, et al. Mol Biol Cell, 2011 Oct. PMID 21849475.
    2. Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis. Bircham PW, et al. Mol Biosyst, 2011 Sep. PMID 21731954.
    3. Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat. Leung A, et al. Mol Biol Cell, 2011 Aug 1. PMID 21680712.
    4. A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae. Finnigan GC, et al. Genetics, 2011 Mar. PMID 21196517.
    5. A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Aguilar PS, et al. Nat Struct Mol Biol, 2010 Jul. PMID 20526336.

    See all (23) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. PER1 encodes an evolutionary conserved component of the Glycosylphoshatidylinositol (GPI) anchor remodeling pathway, highlighting the close connection between the lipid remodeling of GPI and raft association of GPI-anchored proteins.
      Title: PER1 is required for GPI-phospholipase A2 activity and involved in lipid remodeling of GPI-anchored proteins.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:31026 BioGRID:30959 AGP1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35958 ALG5    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:34405 ALG6    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:34466 ALG8    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31026 BioGRID:36693 ANP1    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:31630 ARC18    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:32864 ARL1    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:31026 BioGRID:36129 ARL3    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33662 BCK1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:36905 BEM2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:34072 BLI1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:32607 BNA4    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31351 BOS1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35876 BRE5    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:32984 BSD2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31121 BST1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:31123 BUD27    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:34956 CAP2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31383 CCW12    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:32236 CDC1    BioGRID  PubMed Negative Genetic; Phenotypic Suppression; Synthetic Rescue 
    BioGRID:31026 BioGRID:31579 CDC3    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:36575 CHS7    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35540 CLA4    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33419 CLC1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31772 CNE1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35070 COG8    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:31360 CSF1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33220 CWH41    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:31026 BioGRID:31753 DEP1    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:31740 DRS2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33186 DUO1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35479 DYN3    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:35349 EAR1    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:31694 ECM30    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:34085 ELM1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:36095 ELP3    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31026 BioGRID:32564 EMI1    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:35380 ERG2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:33234 ERG4    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35161 ERG6    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31759 ERP2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33193 ERV14    BioGRID  PubMed Negative Genetic; Phenotypic Suppression 
    BioGRID:31026 BioGRID:35157 ERV25    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:35099 ERV41    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31785 ERV46    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31564 EXG1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31172 FAB1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:32742 FAT1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:31026 BioGRID:35233 FET3    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31717 GAB1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35487 GAS1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35635 GCR2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:36687 GDA1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:33226 GET1    BioGRID  PubMed Negative Genetic; Phenotypic Suppression 
    BioGRID:31026 BioGRID:36828 GET2    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:31026 BioGRID:32414 GGA1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35676 GIM3    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31026 BioGRID:36728 GIM4    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31026 BioGRID:32388 GPI8    BioGRID  PubMed PCA 
    BioGRID:31026 BioGRID:33166 GUP1    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:34469 GYP1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31119 GYP8    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31115 HAC1    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:31026 BioGRID:35338 HLJ1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:33831 HOC1    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:34391 HRD1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:35923 HSP82    BioGRID  PubMed Synthetic Lethality 
    BioGRID:31026 BioGRID:32277 HTA1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:32276 HTB1    BioGRID  PubMed Negative Genetic; Synthetic Rescue 
    BioGRID:31026 BioGRID:33874 ILM1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:36513 IRE1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33080 KEM1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31800 KIN3    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:35518 KRE1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31026 BioGRID:34719 KRE5    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33692 LAS21    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:32554 LPP1    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:34139 MEH1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:35024 MGA2    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:36042 MKK2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33579 MNN11    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:32718 MNN2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:35541 MON2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35544 MSB3    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33459 MVB12    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35174 MVP1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:32213 NBP2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31150 NIC96    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33331 NNF2    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:33829 OPI3    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31612 ORM2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:34483 OST3    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33320 PAC10    BioGRID  PubMed Synthetic Lethality 
    BioGRID:31026 BioGRID:33303 PEF1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:33701 PEP8    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:35080 PGA3    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33566 PHO90    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:33328 PIL1    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:32598 PKC1    BioGRID  PubMed Positive Genetic; Synthetic Lethality 
    BioGRID:31026 BioGRID:35300 PKR1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:36143 PMA2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31007 PMP1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:33087 PMR1    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement 
    BioGRID:31026 BioGRID:31966 PMT1    BioGRID  PubMed Negative Genetic; Phenotypic Suppression 
    BioGRID:31026 BioGRID:31743 PMT2    BioGRID  PubMed Negative Genetic; Phenotypic Suppression 
    BioGRID:31026 BioGRID:31927 PPH21    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:36350 PRP4    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:33678 PRY3    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:32048 PTC1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:32956 RGD1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:32191 RGP1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35665 RIA1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31315 RIC1    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:31026 BioGRID:31114 RIM15    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:36679 RML2    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:33204 RNA15    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:32924 ROT2    BioGRID  PubMed Negative Genetic; Phenotypic Suppression 
    BioGRID:31026 BioGRID:35511 RPD3    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31026 BioGRID:32047 RPT2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:36865 SCS2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35451 SCS7    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:35255 SEC14    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31026 BioGRID:31536 SEC22    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:33115 SEC27    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:34916 SEC28    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:32871 SEC66    BioGRID  PubMed Negative Genetic; Phenotypic Suppression 
    BioGRID:31026 BioGRID:31558 SEC72    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:31043 SED4    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:36552 SET1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:31026 BioGRID:36863 SHO1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35394 SKY1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:32692 SLA1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:36461 SLT2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:34279 SMF1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:31026 BioGRID:33481 SMI1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:36698 SPF1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:32344 SRP101    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:33797 SSC1    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:33873 STE24    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31632 SUR4    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:36187 SUT2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:32376 SWA2    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:32182 SWF1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31026 BioGRID:33585 SWI3    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33753 SYS1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35090 TAF8    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:34385 TLG2    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement 
    BioGRID:31026 BioGRID:32949 TRS20    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33418 TRS65    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31026 BioGRID:32166 TRS85    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:35156 UBX2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:31859 VMA1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33348 VMA21    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31026 BioGRID:36678 VMA8    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:37085 VMA9    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:33349 VOA1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31026 BioGRID:35831 VPS27    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:36439 VPS29    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:31655 VPS33    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:34152 VPS51    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:32536 VPS52    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:32251 VPS64    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31788 VPS8    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31452 VTA1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:36889 YER140W    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:31026 BioGRID:34068 YET1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31106 YFL040W    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31562 YHC1    BioGRID  PubMed Positive Genetic 
    BioGRID:31026 BioGRID:36573 YHR140W    BioGRID  PubMed PCA 
    BioGRID:31026 BioGRID:33589 YJL171C    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31421 YLR152C    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31151 YPI1    BioGRID  PubMed Negative Genetic 
    BioGRID:31026 BioGRID:31529 YPT6    BioGRID  PubMed Synthetic Growth Defect 
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    General gene information

    Homology

    • Homologs of the PER1 gene: The PER1 gene is conserved in human, chimpanzee, cow, mouse, zebrafish, fruit fly, mosquito, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, and rice.

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cellular manganese ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Per1p
    NP_009973.1
    • Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5

      Range
      206877..207950, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178758.1 → NP_009973.1  Per1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P25625
      Conserved Domains (1) summary
      cl02172
      Location:1 – 357
      Blast Score: 1063
      Per1; Per1-like
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006937.2 DAA07522.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P25625.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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