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PIGY phosphatidylinositol glycan anchor biosynthesis class Y [ Homo sapiens (human) ]

Gene ID: 84992, updated on 8-May-2016
Official Symbol
PIGYprovided by HGNC
Official Full Name
phosphatidylinositol glycan anchor biosynthesis class Yprovided by HGNC
Primary source
HGNC:HGNC:28213
See related
Ensembl:ENSG00000255072 HPRD:17492; MIM:610662
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIG-Y; HPMRS6
Summary
The protein encoded by this gene is part of the GPI-N-acetylglucosaminyltransferase (GIP-GnT) complex which initiates the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is synthesized in the endoplasmic reticulum and serves as an anchor for many surface proteins. Proteins containing GPI anchors can have an important role in cell-cell interactions. The transcript for this gene is bicistronic. The downstream open reading frame encodes this GPI-GnT complex protein, while the upstream open reading frame encodes a protein with unknown function, as represented by GeneID:100996939. [provided by RefSeq, Aug 2012]
Orthologs
Location:
4q22.1
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (88520978..88523801, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (89442129..89444952, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723458 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 5 Neighboring gene nuclear receptor coactivator 4 pseudogene Neighboring gene uncharacterized LOC101929134 Neighboring gene CD53 molecule pseudogene Neighboring gene PIGY upstream reading frame

NHGRI GWAS Catalog

Description
A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of phosphatidylinositol glycan anchor biosynthesis, class Y (PIGY) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC14156

Gene Ontology Provided by GOA

Process Evidence Code Pubs
GPI anchor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
Names
phosphatidylinositol-glycan biosynthesis class Y protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046719.1 RefSeqGene

    Range
    5001..7824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042616.2NP_001036081.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit Y

    See identical proteins and their annotated locations for NP_001036081.1

    Status: REVIEWED

    Source sequence(s)
    AB206972, AC083829, BI548853, DB519150
    Consensus CDS
    CCDS54778.1
    UniProtKB/Swiss-Prot
    Q3MUY2
    Related
    ENSP00000432688, OTTHUMP00000233427, ENST00000527353, OTTHUMT00000390410
    Conserved Domains (1) summary
    pfam15159
    Location:471
    PIG-Y; Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    88520978..88523801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    89418607..89421430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)