UBASH3B ubiquitin associated and SH3 domain containing B [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: UBASH3Bprovided by HGNC
Official Full Name: ubiquitin associated and SH3 domain containing Bprovided by HGNC
Primary source: HGNC:29884
See related: Ensembl:ENSG00000154127; HPRD:16463; MIM:609201; Vega:OTTHUMG00000166025
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p70; STS1; STS-1; TULA-2; KIAA1959; MGC15437
Summary: This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 11q24.1

Sequence :: Chromosome: 11; NC_000011.9 (122526398..122685187)

See UBASH3B in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ablation of TULA-2 resulted in hyperphosphorylation of Syk and its downstream effector phospholipase C-gamma2 as well as enhanced GPVI-mediated platelet functional responses.
Title: A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
TULA proteins TULA and TULA-2 regulate activity of the protein tyrosine kinase Syk
Title: TULA proteins regulate activity of the protein tyrosine kinase Syk.
hsp70 inhibits apoptosis upstream and downstream of the mitochondria and is a promising therapeutic target for reversing drug-resistance in chronic myeloid leukemia-blast crisis and acute myeloid leukemia cells.
Title: Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells.
Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases
Title: Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.

Submit: New GeneRIF Correction

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
Suppressor of T-cell receptor signaling 1	P22681	CBL	HPRD	PubMed
Suppressor of T-cell receptor signaling 1	O60674	JAK2	HPRD	PubMed
Suppressor of T-cell receptor signaling 1	Ubiquitin B	UBB	HPRD	PubMed
BioGRID:124390	BioGRID:107315	CBL	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:124390	BioGRID:107533	CHD4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:124390	BioGRID:108276	EGFR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:124390	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:124390	BioGRID:114346	SAP30	BioGRID	PubMed	Affinity Capture-MS
BioGRID:124390	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:124390	BioGRID:116249	UBE2C	BioGRID	PubMed	Biochemical Activity
BioGRID:124390	BioGRID:113169	UBE2D1	BioGRID	PubMed	Biochemical Activity
BioGRID:124390	BioGRID:113170	UBE2D2	BioGRID	PubMed	Biochemical Activity
BioGRID:124390	BioGRID:113171	UBE2D3	BioGRID	PubMed	Biochemical Activity
BioGRID:124390	BioGRID:113172	UBE2E1	BioGRID	PubMed	Biochemical Activity
BioGRID:124390	BioGRID:113176	UBE2H	BioGRID	PubMed	Biochemical Activity

Function	Evidence Code	Pubs
hydrolase activity	IEA Inferred from Electronic Annotation more info
protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: ubiquitin-associated and SH3 domain-containing protein B

Names: ubiquitin-associated and SH3 domain-containing protein B; T-cell ubiquitin ligand 2; cbl-interacting protein p70; Cbl-interacting protein Sts-1; nm23-phosphorylated unknown substrate; tyrosine-protein phosphatase STS1/TULA2; suppressor of T-cell receptor signaling 1; SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate

NP_116262.2

EC 3.1.3.48

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032873.4 → NP_116262.2 ubiquitin-associated and SH3 domain-containing protein B

Status: VALIDATED

Source sequence(s)

AK075203, AP002762, BC007541, CR741636, DA197468

Consensus CDS

CCDS31694.1

UniProtKB/Swiss-Prot

Q8TF42

Related

ENSP00000284273, OTTHUMP00000231738, ENST00000284273, OTTHUMT00000387499

Conserved Domains (4) summary

cd00174
Location:258 – 316
Blast Score: 107

SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

cd00194
Location:39 – 75
Blast Score: 116

UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...

cd07067
Location:386 – 598
Blast Score: 198

HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction.

pfam13563
Location:125 – 217
Blast Score: 90

2_5_RNA_ligase2; 2'-5' RNA ligase superfamily

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p5 Primary Assembly

Range

122526398..122685187

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

118468875..118627622

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP002762.4 (7634..166385)	None
genomic	CH471065.1	EAW67531.1
genomic	CQ783295.1	CAF86506.1
genomic	HI573876.1	CBX47427.1
mRNA	AB075839.1	BAB85545.1
mRNA	AF425252.1	AAL16953.1
mRNA	AK075203.1	BAC11468.1
mRNA	AK092011.1	None
mRNA	AK222843.1	BAD96563.1
mRNA	AK222846.1	BAD96566.1
mRNA	AL833092.2	None
mRNA	BC007541.1	AAH07541.2
mRNA	CA313832.1	None
mRNA	CR741636.1	None
mRNA	DA197468.1	None