Format

Send to:

Choose Destination

ATOH8 atonal bHLH transcription factor 8 [ Homo sapiens (human) ]

Gene ID: 84913, updated on 26-May-2016
Official Symbol
ATOH8provided by HGNC
Official Full Name
atonal bHLH transcription factor 8provided by HGNC
Primary source
HGNC:HGNC:24126
See related
Ensembl:ENSG00000168874 HPRD:09813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HATH6; bHLHa21
Orthologs
Location:
2p11.2
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (85753786..85791383)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85980909..86018506)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 160 pseudogene Neighboring gene granulysin Neighboring gene microRNA 6071 Neighboring gene uncharacterized LOC284950 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ14708, FLJ38730

Gene Ontology Provided by GOA

Function Evidence Code Pubs
E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
activating transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
formation of primary germ layer ISS
Inferred from Sequence or Structural Similarity
more info
 
myoblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
tube formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein atonal homolog 8
Names
atonal homolog 6
atonal homolog 8
atonal homolog bHLH transcription factor 8
basic helix loop helix transcription factor 6
basic helix-loop-helix transcription factor 6
class A basic helix-loop-helix protein 21
helix-loop-helix protein hATH-6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032827.6NP_116216.2  protein atonal homolog 8

    See identical proteins and their annotated locations for NP_116216.2

    Status: VALIDATED

    Source sequence(s)
    AC012454, BC094832, BM671127, BQ018438, DA629171
    Consensus CDS
    CCDS1985.1
    UniProtKB/Swiss-Prot
    Q96SQ7
    Related
    ENSP00000304676, OTTHUMP00000160681, ENST00000306279, OTTHUMT00000252496
    Conserved Domains (1) summary
    cd00083
    Location:231285
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    85753786..85791383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533139.1XP_011531441.1  

    Conserved Domains (1) summary
    cd00083
    Location:231285
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  2. XM_006712122.2XP_006712185.1  

    Conserved Domains (1) summary
    cd00083
    Location:231285
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  3. XM_011533140.1XP_011531442.1  

    Conserved Domains (1) summary
    cd00083
    Location:231285
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RNA

  1. XR_939732.1 RNA Sequence

  2. XR_939731.1 RNA Sequence

  3. XR_939733.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    85910490..85948082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)