Format

Send to:

Choose Destination

TBRG1 transforming growth factor beta regulator 1 [ Homo sapiens (human) ]

Gene ID: 84897, updated on 8-May-2016
Official Symbol
TBRG1provided by HGNC
Official Full Name
transforming growth factor beta regulator 1provided by HGNC
Primary source
HGNC:HGNC:29551
See related
Ensembl:ENSG00000154144 HPRD:15477; MIM:610614; Vega:OTTHUMG00000153024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIAM; TB-5
Orthologs
Location:
11q24.2
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (124622599..124635926)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124492742..124505822)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 8 subfamily A member 1 Neighboring gene olfactory receptor family 8 subfamily Q member 1 pseudogene Neighboring gene pannexin 3 Neighboring gene RNA, 5S ribosomal pseudogene 352 Neighboring gene sialic acid acetylesterase Neighboring gene sperm autoantigenic protein 17

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ14621, FLJ25020, FLJ90113, MGC129890

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleolus to nucleoplasm transport IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
transforming growth factor beta regulator 1
Names
nuclear interactor of ARF and MDM2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032811.2NP_116200.2  transforming growth factor beta regulator 1

    See identical proteins and their annotated locations for NP_116200.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    AP001524, DA292015, DQ144542
    Consensus CDS
    CCDS8448.2
    UniProtKB/Swiss-Prot
    Q3YBR2
    Related
    ENSP00000409016, OTTHUMP00000202914, ENST00000441174, OTTHUMT00000329057
    Conserved Domains (2) summary
    pfam05964
    Location:187240
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:242318
    FYRC; F/Y rich C-terminus

RNA

  1. NR_016021.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. While variant 2 appears to be the predominant variant, it is likely that it does not encode a protein.
    Source sequence(s)
    AK027527, AP001524, DA292015
    Related
    ENST00000284290, OTTHUMT00000329059

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    124622599..124635926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271709.2XP_005271766.1  

    Conserved Domains (2) summary
    pfam05964
    Location:5193
    FYRN; F/Y-rich N-terminus
    pfam05965
    Location:95171
    FYRC; F/Y rich C-terminus
  2. XM_011543040.1XP_011541342.1  

  3. XM_005271711.2XP_005271768.1  

RNA

  1. XR_428983.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    124378866..124391953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)