TBRG1 transforming growth factor beta regulator 1 [Homo sapiens] - Gene

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Summary

Official Symbol: TBRG1provided by HGNC
Official Full Name: transforming growth factor beta regulator 1provided by HGNC
Primary source: HGNC:29551
See related: Ensembl:ENSG00000154144; HPRD:15477; MIM:610614; Vega:OTTHUMG00000153024
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NIAM; TB-5; FLJ14621; FLJ25020; FLJ90113; MGC129890

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Genomic context

Location :: 11q24.2

Sequence :: Chromosome: 11; NC_000011.9 (124492742..124505822)

See TBRG1 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sructure of a fragment of TBRG1 was shown to encompasses two motifs. The FYRN and FYRC regions each form part of a single folded module (the FYR domain), which adopts a novel alpha + beta fold.
Title: The structure of the FYR domain of transforming growth factor beta regulator 1.
NIAM is a nuclear interactor of ARF and Mdm2
Title: Generation and characterization of monoclonal antibodies to NIAM: a nuclear interactor of ARF and Mdm2.
novel protein with tumor suppressor-like behaviors and functional links to ARF-MDM2-p53 signaling
Title: A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q3YBR2	Q8N726	CDKN2A	HPRD	PubMed
BioGRID:124337	BioGRID:110358	MDM2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:124337	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
cell cycle	IEA Inferred from Electronic Annotation more info
cell cycle arrest	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
nucleolus to nucleoplasm transport	IDA Inferred from Direct Assay more info	PubMed
protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: transforming growth factor beta regulator 1

Names: transforming growth factor beta regulator 1; nuclear interactor of ARF and MDM2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032811.2 → NP_116200.2 transforming growth factor beta regulator 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer, protein-coding transcript.

Source sequence(s)

AP001524, DA292015, DQ144542

Consensus CDS

CCDS8448.2

UniProtKB/Swiss-Prot

Q3YBR2

Related

ENSP00000409016, OTTHUMP00000202914, ENST00000441174, OTTHUMT00000329057

Conserved Domains (2) summary

cl02650
Location:187 – 240
Blast Score: 247

FYRN; F/Y-rich N-terminus

cl02651
Location:242 – 318
Blast Score: 244

FYRC; F/Y rich C-terminus

RNA

NR_016021.1 RNA Sequence

Description

Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. While variant 2 appears to be the predominant variant, it is likely that it does not encode a protein.

Source sequence(s)

AK027527, AP001524, DA292015

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p5 Primary Assembly

Range

124492742..124505822

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

120435201..120448281

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP001524.4 (97845..110897)	None
genomic	CH471065.1	EAW67589.1
		EAW67590.1
mRNA	AK027527.1	BAB55177.1
mRNA	AK027766.1	None
mRNA	AK057749.1	BAB71559.1
mRNA	AK074140.1	BAB84966.1
mRNA	AK074594.1	None
mRNA	AK222936.1	BAD96656.1
mRNA	AL713631.1	CAD28450.1
mRNA	AL831881.1	CAH10595.1
mRNA	AY696294.1	AAU10523.1
mRNA	BC018452.1	AAH18452.1
mRNA	BC032312.1	AAH32312.1
mRNA	BC041043.1	AAH41043.1
mRNA	BC064392.1	None
mRNA	BC073160.1	AAH73160.1
mRNA	BC107428.1	None
mRNA	BC109269.2	AAI09270.1
mRNA	DA292015.1	None
mRNA	DQ144542.1	AAZ76016.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q05BL0	GenPept	UniProtKB/TrEMBL:Q05BL0
Q3YBR2.1	GenPept	UniProtKB/Swiss-Prot:Q3YBR2
Q6GPH2	GenPept	UniProtKB/TrEMBL:Q6GPH2
Q96LV8	GenPept	UniProtKB/TrEMBL:Q96LV8