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KLHL22 kelch like family member 22 [ Homo sapiens (human) ]

Gene ID: 84861, updated on 8-May-2016
Official Symbol
KLHL22provided by HGNC
Official Full Name
kelch like family member 22provided by HGNC
Primary source
HGNC:HGNC:25888
See related
Ensembl:ENSG00000099910 HPRD:07858; Vega:OTTHUMG00000188269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KELCHL
Orthologs
Location:
22q11.21
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 22 NC_000022.11 (20441519..20495883, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20795806..20850170, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 74 Neighboring gene scavenger receptor class F member 2 Neighboring gene kelch like family member 12 pseudogene Neighboring gene uncharacterized LOC105372940 Neighboring gene uncharacterized LOC105372939 Neighboring gene RNA, Ro-associated Y1 pseudogene 9 Neighboring gene keratin 18 pseudogene 5 Neighboring gene uncharacterized LOC101928824 Neighboring gene uncharacterized LOC105372938 Neighboring gene mediator complex subunit 15

NHGRI GWAS Catalog

Description
Genome-wide association study of retinopathy in individuals without diabetes.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
polar microtubule IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
kelch-like protein 22
Names
kelch-like 22
kelch-like family member 22

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032775.3NP_116164.2  kelch-like protein 22

    See identical proteins and their annotated locations for NP_116164.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    BC015923, DA381792
    Consensus CDS
    CCDS13780.1
    UniProtKB/Swiss-Prot
    Q53GT1
    Related
    ENSP00000331682, OTTHUMP00000198478, ENST00000328879, OTTHUMT00000320045
    Conserved Domains (6) summary
    smart00612
    Location:447493
    Kelch; Kelch domain
    smart00225
    Location:51145
    BTB; Broad-Complex, Tramtrack and Bric a brac
    PHA03098
    Location:52592
    PHA03098; kelch-like protein; Provisional
    pfam01344
    Location:393433
    Kelch_1; Kelch motif
    cd14735
    Location:147205
    BACK_Kelch; BTB-And-C-terminal-Kelch (BACK) domain of Kelch-like proteins
    sd00038
    Location:340385
    Kelch; KELCH repeat [structural motif]

RNA

  1. NR_033825.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007731, AK294682, BC015923, DA381792

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p2 Primary Assembly

    Range
    20441519..20495883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530469.1XP_011528771.1  

    Conserved Domains (4) summary
    smart00225
    Location:51145
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam01344
    Location:393433
    Kelch_1; Kelch motif
    cd14735
    Location:147205
    BACK_Kelch; BTB-And-C-terminal-Kelch (BACK) domain of Kelch-like proteins
    sd00038
    Location:340385
    Kelch; KELCH repeat [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 Alternate CHM1_1.1

    Range
    20796082..20850455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)