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LMNB2 lamin B2 [ Homo sapiens (human) ]

Gene ID: 84823, updated on 22-Nov-2014
Official Symbol
LMNB2provided by HGNC
Official Full Name
lamin B2provided by HGNC
Primary source
HGNC:HGNC:6638
See related
Ensembl:ENSG00000176619; HPRD:01037; MIM:150341; Vega:OTTHUMG00000150626
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LMN2; LAMB2
Summary
This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]
See LMNB2 in Epigenomics, MapViewer
Location:
19p13.3
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (2428165..2456968, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2428163..2456966, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene signal peptide peptidase like 2B Neighboring gene transmembrane protease, serine 9 Neighboring gene translocase of inner mitochondrial membrane 13 homolog (yeast) Neighboring gene microRNA 7108 Neighboring gene uncharacterized LOC101928602 Neighboring gene growth arrest and DNA-damage-inducible, beta

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Purified HIV-1 Tat has been shown to bind with high affinity to the nuclear matrix from H9 cells and to link viral RNAs to the nuclear matrix PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of lamin B2 (LMNB2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
vpr HIV-1 Vpr co-localizes with lamin B and induces localized disruptions in the normal nuclear lamin architecture, contributing to the formation of nuclear envelope herniations PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC2721, FLJ26130

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
lamin filament IEA
Inferred from Electronic Annotation
more info
 
nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008355.1 

    Range
    4993..33796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032737.3NP_116126.3  lamin-B2

    See proteins identical to NP_116126.3

    Status: REVIEWED

    Source sequence(s)
    AC011522, AL560944, BC006551
    Consensus CDS
    CCDS12090.2
    UniProtKB/TrEMBL
    J9JID7
    UniProtKB/Swiss-Prot
    Q03252
    Related
    ENSP00000327054, OTTHUMP00000198023, ENST00000325327, OTTHUMT00000319205
    Conserved Domains (2) summary
    pfam00038
    Location:45401
    Filament; Intermediate filament protein
    pfam00932
    Location:467582
    LTD; Lamin Tail Domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    2200214..2228845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    2428165..2456968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    2427662..2456465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)