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    RAE1 RAE1 RNA export 1 homolog (S. pombe) [ Homo sapiens ]

    Gene ID: 8480, updated on 19-May-2012
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    Summary

    Official Symbol
    RAE1provided by HGNC
    Official Full Name
    RAE1 RNA export 1 homolog (S. pombe)provided by HGNC
    Primary source
    HGNC:9828
    Locus tag
    RP4-800J21.2
    See related
    Ensembl:ENSG00000101146; HPRD:11939; MIM:603343; Vega:OTTHUMG00000032819
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1; FLJ30608; MGC117333; MGC126076; MGC126077
    Summary
    Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    20q13.31
    Sequence :
    Chromosome: 20; NC_000020.10 (55926145..55953519)
    See RAE1 in Epigenomics, MapViewer

    Chromosome 20 - NC_000020.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene 39 Neighboring gene SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae) Neighboring gene transfer RNA leucine 42 (anticodon UAA) pseudogene Neighboring gene MT-RNR2-like 3 Neighboring gene uncharacterized LOC100291105 Neighboring gene RNA binding motif protein 38 Neighboring gene high mobility group box 1 pseudogene 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans. Grill B, et al. J Neurosci, 2012 Feb 22. PMID 22357847.
    2. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Altun M, et al. Chem Biol, 2011 Nov 23. PMID 22118674.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis. Funasaka T, et al. Cell Cycle, 2011 May 1. PMID 21467841.

    See all (36) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. This study established a novel postmitotic function for rae-1 in neuronal development.
      Title: RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans.
    2. RAE1 transgene orchestrates proper chromosome segregation and NUP98-mediated leukemogenesis.
      Title: RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis.
    3. In a transgenic mouse model of chronic natural killer NKG2D ligand expression, constant exposure to NKG2D ligand RNA export 1 homolog (Rae-1 epsilon) does not functionally impair NK cells or CD8-positive T cells in the context of viral infection.
      Title: Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1.
    4. present the crystal structure of human Rae1 in complex with the Gle2-binding sequence (GLEBS) of Nup98 at 1.65 A resolution. Rae1 forms a seven-bladed beta-propeller with several extensive surface loops.
      Title: Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1.
    5. Interaction between Rae1 and cohesin subunit SMC1 is required for proper spindle formation.
      Title: Interaction between Rae1 and cohesin subunit SMC1 is required for proper spindle formation.
    6. Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation.
      Title: Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation.
    7. point to the Rae1-NuMA interaction as a critical element for normal spindle formation in mitosis
      Title: Rae1 interaction with NuMA is required for bipolar spindle formation.
    8. VSV M protein blocks mRNA export by disrupting Rae1 function, which can be reverted by induction of Rae1 expression.
      Title: VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway.
    9. These data show an association of mrnp41 with MT and, moreover, demonstrate that an intact MT system is necessary for dispersion of mrnp41-containing particles to the cellular periphery
      Title: Mrnp41 (Rae 1p) associates with microtubules in HeLa cells and in neurons.
    10. A purified Rae1 complex stabilizes microtubules in egg extracts in a RanGTP/importin beta-regulated manner
      Title: A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_003601.1 AAA48443.1     BIND  PubMed Matrix interacts with Rae1. 
    P78406 O43683 BUB1    HPRD  PubMed  
    P78406 Q9GZR7 DDX24    HPRD  PubMed  
    P78406 O43908 KLRC4    HPRD  PubMed  
    P78406 P52948 NUP98    HPRD  PubMed  
    P78406 Q9UBU9 NXF1    HPRD  PubMed  
    BioGRID:114054 BioGRID:120419 AGGF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:117376 ARMC8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:116282 ATE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:107164 BUB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114054 BioGRID:198404 Bub1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114054 BioGRID:116176 COPS6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:116124 COPS8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:107818 CS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:116426 DDX19B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:116298 FAF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:127730 FAM122B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:113036 HSP90B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:108918 KAT2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:116576 KLRK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114054 BioGRID:123521 MAGED4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:110304 MAP1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:119974 MIOS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:110497 MPST    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:116709 MYCBP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:117058 NUP188    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:113717 NUP214    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:117165 NUP62    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:110981 NUP88    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:115041 NUP93    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:110982 NUP98    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114054 BioGRID:116278 NUPL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:230667 Nup188    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:230673 Nup214    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:111418 POLA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:117176 POLA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:116301 POLR3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:120828 POLR3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:120840 POLR3E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:128147 POLR3H    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:111547 PRIM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:111548 PRIM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:117384 PRKD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:117199 PRKD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:114663 PTTG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114054 BioGRID:115265 RBM8A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:114546 SART1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:123629 SEH1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:115580 SF3A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:113826 SF3A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:116146 SF3A3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:113871 SMC1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114054 BioGRID:114574 SMC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114054 BioGRID:120528 SMU1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:112937 TJP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:114809 TJP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:113200 UFD1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:113866 USP11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:113622 USP7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:123953 WDR24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:123195 WDR26    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:122841 WDR59    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114054 BioGRID:123901 WDR75    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the RAE1 gene: The RAE1 gene is conserved in , dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
      Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystem (from REACTOME)
      Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystemInfluenza genomic RNA (vRNA), synthesized in the nucleus of the infected host cell, is packaged into ribonucleoprotein (RNP) complexes containing viral polymerase proteins and NP (nucleocapsid). NP ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Glucose transport, organism-specific biosystem (from REACTOME)
      Glucose transport, organism-specific biosystemCells take up glucose by facilitated diffusion, via glucose transporters (GLUTs) associated with the plasma membrane, a reversible reaction (Joost and Thorens 2001). Four tissue-specific GLUT isoform...
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • HIV Life Cycle, organism-specific biosystem (from REACTOME)
      HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
    • Hexose transport, organism-specific biosystem (from REACTOME)
      Hexose transport, organism-specific biosystemHexoses, notably fructose, glucose, and galactose, generated in the lumen of the small intestine by breakdown of dietary carbohydrate are taken up by enterocytes lining the microvilli of the small in...
    • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
      Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
    • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
      ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza Infection, organism-specific biosystem (from REACTOME)
      Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
    • Influenza Life Cycle, organism-specific biosystem (from REACTOME)
      Influenza Life Cycle, organism-specific biosystemThe virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanis...
    • Interactions of Rev with host cellular proteins, organism-specific biosystem (from REACTOME)
      Interactions of Rev with host cellular proteins, organism-specific biosystemIn order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles between the cytoplasm and nucleus using host cell transport mechanisms (reviewed in Li et al. 2005). Nucl...
    • Interactions of Vpr with host cellular proteins, organism-specific biosystem (from REACTOME)
      Interactions of Vpr with host cellular proteins, organism-specific biosystemVpr has been implicated in multiple processes during HIV-1 replication, including nuclear import of the pre-integration complex (PIC)(Heinzinger et al., 1994), apoptosis (Stewart et al., 1997) and in...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
      Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
      Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
    • Metabolism of non-coding RNA, organism-specific biosystem (from REACTOME)
      Metabolism of non-coding RNA, organism-specific biosystemThe term non-coding is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. There is considerable evidence tha...
    • NEP/NS2 Interacts with the Cellular Export Machinery, organism-specific biosystem (from REACTOME)
      NEP/NS2 Interacts with the Cellular Export Machinery, organism-specific biosystemThe viral RNP complex is exported from the nucleus via the host cell CRM1 export pathway (Fukuda, 1997; Neumann, 2000; reviewed in Buolo, 2006). The vRNP complex does not interact directly with CRM1 ...
    • Nuclear import of Rev protein, organism-specific biosystem (from REACTOME)
      Nuclear import of Rev protein, organism-specific biosystemNuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev pr...
    • Nuclear pore complex, organism-specific biosystem (from KEGG)
      Nuclear pore complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Regulation of Glucokinase by Glucokinase Regulatory Protein, organism-specific biosystem (from REACTOME)
      Regulation of Glucokinase by Glucokinase Regulatory Protein, organism-specific biosystemGlucokinase (GCK1) is negatively regulated by glucokinase regulatory protein (GKRP), which reversibly binds the enzyme to form an inactive complex. Binding is stimulated by fructose 6-phosphate and s...
    • Rev-mediated nuclear export of HIV-1 RNA, organism-specific biosystem (from REACTOME)
      Rev-mediated nuclear export of HIV-1 RNA, organism-specific biosystemThe HIV-1 genome contains 9 genes encoded by a single transcript. In order for the virus to replicate, unspliced, singly-spliced and fully spliced viral mRNA must be exported from the nucleus. The H...
    • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
      SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Transport of Mature Transcript to Cytoplasm, organism-specific biosystem (from REACTOME)
      Transport of Mature Transcript to Cytoplasm, organism-specific biosystemTransport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets. The separation of the two compartments and the regulation of this tran...
    • Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystem (from REACTOME)
      Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing.
    • Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystem (from REACTOME)
      Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing. This coupling is achieved by the nuclear p...
    • Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystem (from REACTOME)
      Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystemTransport of mature mRNAs derived from intronless transcripts require some of the same protein complexes as mRNAs derived from intron containing complexes, including TAP and Aly/Ref. However a number...
    • Transport of Ribonucleoproteins into the Host Nucleus, organism-specific biosystem (from REACTOME)
      Transport of Ribonucleoproteins into the Host Nucleus, organism-specific biosystemAn unusual characteristic of the influenza virus life cycle is its dependence on the nucleus. Trafficking of the viral genome into and out of the nucleus is a tightly regulated process with all viral...
    • Transport of the SLBP Dependant Mature mRNA, organism-specific biosystem (from REACTOME)
      Transport of the SLBP Dependant Mature mRNA, organism-specific biosystemTransport of U7 snRNP and stem-loop binding protein (SLBP) processed mRNA.
    • Transport of the SLBP independent Mature mRNA, organism-specific biosystem (from REACTOME)
      Transport of the SLBP independent Mature mRNA, organism-specific biosystemTransport of the SLBP independent Mature mRNA through the nuclear pore.
    • Vpr-mediated nuclear import of PICs, organism-specific biosystem (from REACTOME)
      Vpr-mediated nuclear import of PICs, organism-specific biosystemVpr appears to function in anchoring the PIC to the nuclear envelope. This anchoring likely involves interactions between Vpr and host nucleoporins.
    • snRNP Assembly, organism-specific biosystem (from REACTOME)
      snRNP Assembly, organism-specific biosystemSmall nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    carbohydrate metabolic process TAS
    Traceable Author Statement
    more info
    		  
    cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    glucose transport TAS
    Traceable Author Statement
    more info
    		  
    hexose transport TAS
    Traceable Author Statement
    more info
    		  
    mRNA export from nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of glucose transport TAS
    Traceable Author Statement
    more info
    		  
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    viral reproduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nuclear envelope TAS
    Traceable Author Statement
    more info
    		  
    nuclear outer membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nuclear pore TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    mRNA export factor
    Names
    mRNA export factor
    mRNA export protein
    rae1 protein homolog
    migration-inducing gene 14
    mRNA-binding protein, 41-kD
    mRNA-associated protein MRNP 41
    homolog of yeast Rae1 (Bharathi) mRNA-associated protein of 41 kDa (Kraemer)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015885.1 → NP_001015885.1  mRNA export factor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR and encodes the same protein, as compared to variant 1.
      Source sequence(s)
      AI341915, AY349350, U84720
      Consensus CDS
      CCDS13458.1
      UniProtKB/TrEMBL
      A8K882
      UniProtKB/Swiss-Prot
      P78406
      Related
      ENSP00000379181, OTTHUMP00000166111, ENST00000395840, OTTHUMT00000259500
      Conserved Domains (1) summary
      cl02567
      Location:40 – 335
      Blast Score: 254
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_003610.3 → NP_003601.1  mRNA export factor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs from variant 2 in the 5' UTR and encodes the same protein as variant 2.
      Source sequence(s)
      AI341915, AL135939, AY349350, U84720
      Consensus CDS
      CCDS13458.1
      UniProtKB/TrEMBL
      A8K882
      UniProtKB/Swiss-Prot
      P78406
      Related
      ENSP00000379182, OTTHUMP00000031366, ENST00000395841, OTTHUMT00000079842
      Conserved Domains (1) summary
      cl02567
      Location:40 – 335
      Blast Score: 254
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000020.10 Reference GRCh37.p5 Primary Assembly

      Range
      55926145..55953519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000152.1 Alternate HuRef

      Range
      52708342..52735720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL109955.38 CAX15041.1
    genomic AL135939.12 CAI21524.1
      CAM28253.1
      CAM28254.1
    genomic CH471077.2 EAW75523.1
      EAW75524.1
      EAW75525.1
    mRNA AI341915.1 None
    mRNA AK055170.1 None
    mRNA AK126024.1 None
    mRNA AK292247.1 BAF84936.1
    mRNA AK307966.1 None
    mRNA AK309069.1 None
    mRNA AK309743.1 None
    mRNA AY336091.1 AAR24621.1
    mRNA AY349350.1 AAR04856.1
    mRNA BC103754.1 AAI03755.1
    mRNA BC106923.1 AAI06924.1
    mRNA BC106924.1 AAI06925.1
    mRNA U84720.1 AAC28126.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78406.1 GenPept UniProtKB/Swiss-Prot:P78406
    Q5J8M4 GenPept UniProtKB/TrEMBL:Q5J8M4
    Help top of page

    Additional Links

    Gene LinkOut

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