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    PCGF1 polycomb group ring finger 1 [ Homo sapiens (human) ]

    Gene ID: 84759, updated on 14-May-2013
    Official Symbol
    PCGF1provided by HGNC
    Official Full Name
    polycomb group ring finger 1provided by HGNC
    Primary source
    HGNC:17615
    See related
    HPRD:11404; MIM:610231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NSPC1; RNF68; RNF3A-2; 2010002K04Rik
    Summary
    PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008]
    Location :
    2p13.1
    Sequence :
    Chromosome: 2; NC_000002.11 (74732170..74734821, complement)
    See PCGF1 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 142 Neighboring gene tetratricopeptide repeat domain 31 Neighboring gene ladybird homeobox 2 Neighboring gene LBX2 antisense RNA 1 Neighboring gene T-cell leukemia homeobox 2 Neighboring gene DEAQ box RNA-dependent ATPase 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624.
    2. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. Woodsmith J, et al. Mol Cell Proteomics, 2012 Jul. PMID 22493164.
    3. PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Gao Z, et al. Mol Cell, 2012 Feb 10. PMID 22325352.
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.

    See all (20) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. polycomb has a role in stem cell fate and development of cancer (review)
      Title: Stem cells and cancer; the polycomb connection.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    Q9BSM1 NDP52 CALCOCO2    HPRD  PubMed  
    BioGRID:124243 BioGRID:120228 BCOR    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:124243 BioGRID:121961 BCORL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124243 BioGRID:115535 CALCOCO2    BioGRID  PubMed Two-hybrid 
    BioGRID:124243 BioGRID:117028 CBX6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:124243 BioGRID:117044 CBX7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:124243 BioGRID:121487 CBX8    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:124243 BioGRID:115021 DZIP3    BioGRID  PubMed Two-hybrid 
    BioGRID:124243 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:124243 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124243 BioGRID:124197 KDM2B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:124243 BioGRID:110446 MLLT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124243 BioGRID:124243 PCGF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124243 BioGRID:123896 PCGF6    BioGRID  PubMed Two-hybrid 
    BioGRID:124243 BioGRID:119594 PHF7    BioGRID  PubMed Two-hybrid 
    BioGRID:124243 BioGRID:111947 RING1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:124243 BioGRID:115249 RNF10    BioGRID  PubMed Two-hybrid 
    BioGRID:124243 BioGRID:120281 RNF125    BioGRID  PubMed Two-hybrid 
    BioGRID:124243 BioGRID:111972 RNF2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:124243 BioGRID:116997 RYBP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:124243 BioGRID:112391 SKP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124243 BioGRID:124194 TRIM55    BioGRID  PubMed Two-hybrid 
    BioGRID:124243 BioGRID:132031 TRIM74    BioGRID  PubMed Two-hybrid 
    BioGRID:124243 BioGRID:123541 TRIM8    BioGRID  PubMed Two-hybrid 
    BioGRID:124243 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124243 BioGRID:127156 UBE2U    BioGRID  PubMed Two-hybrid 
    BioGRID:124243 BioGRID:113622 USP7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124243 BioGRID:115441 YAF2    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ43754, MGC10882

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    histone H2A monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    PcG protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    polycomb group RING finger protein 1
    Names
    polycomb group RING finger protein 1
    RING finger protein 68
    nervous system Polycomb-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032673.2 → NP_116062.2  polycomb group RING finger protein 1

      Status: VALIDATED

      Source sequence(s)
      BC004952, BU602498
      Consensus CDS
      CCDS1946.2
      UniProtKB/Swiss-Prot
      Q9BSM1
      Conserved Domains (1) summary
      cd00162
      Location:47 – 89
      Blast Score: 112
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p10 Primary Assembly

      Range
      74732170..74734821, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      74468431..74471082, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018913.1 Alternate CHM1_1.0

      Range
      74603409..74606060, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01075602.1 (36273..38924) None
    genomic AC005041.2 (27641..30257) None
    genomic AMYH01010454.1 (380736..383387) None
    genomic CH471053.2 EAW99632.1
      EAW99633.1
    mRNA AF087884.1 AAP97183.1
    mRNA AK125742.1 None
    mRNA BC004952.1 AAH04952.1
    mRNA BU602498.1 None
    mRNA AL049296.1 None
    other-genetic HQ447406.1 ADQ31892.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BSM1.2 GenPept UniProtKB/Swiss-Prot:Q9BSM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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