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CNDP1 carnosine dipeptidase 1 [ Homo sapiens (human) ]

Gene ID: 84735, updated on 22-May-2016
Official Symbol
CNDP1provided by HGNC
Official Full Name
carnosine dipeptidase 1provided by HGNC
Primary source
HGNC:HGNC:20675
See related
Ensembl:ENSG00000150656 HPRD:09883; HPRD:09894; MIM:609064; Vega:OTTHUMG00000132852
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CN1; CPGL2; HsT2308
Summary
This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region. [provided by RefSeq, Jul 2008]
Orthologs
Location:
18q22.3
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 18 NC_000018.10 (74534457..74585025)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (72201692..72252261)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372193 Neighboring gene CNDP dipeptidase 2 (metallopeptidase M20 family) Neighboring gene long intergenic non-protein coding RNA 909 Neighboring gene zinc finger protein 407 Neighboring gene uncharacterized LOC105372197

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC10825, MGC102737, MGC142072

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
dipeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
tripeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
beta-Ala-His dipeptidase
Names
CNDP dipeptidase 1
carnosinase 1
carnosine dipeptidase 1 (metallopeptidase M20 family)
glutamate carboxypeptidase-like protein 2
serum carnosinase
NP_116038.4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033025.1 RefSeqGene

    Range
    5001..55570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032649.5NP_116038.4  beta-Ala-His dipeptidase precursor

    See identical proteins and their annotated locations for NP_116038.4

    Status: REVIEWED

    Source sequence(s)
    AK098369, AY358756, BG202268, BI597577, BM662490, H41544
    Consensus CDS
    CCDS12007.1
    UniProtKB/Swiss-Prot
    Q96KN2
    Related
    ENSP00000351682, OTTHUMP00000163751, ENST00000358821, OTTHUMT00000256326
    Conserved Domains (2) summary
    PRK08201
    Location:34506
    PRK08201; hypothetical protein; Provisional
    cd05676
    Location:38506
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p2 Primary Assembly

    Range
    74534457..74585025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    72197014..72247620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)