MYO18B myosin XVIIIB [Homo sapiens] - Gene

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Summary

Official Symbol: MYO18Bprovided by HGNC
Official Full Name: myosin XVIIIBprovided by HGNC
Primary source: HGNC:18150
Locus tag: CTA-109D1.1
See related: Ensembl:ENSG00000133454; HPRD:09529; MIM:607295; Vega:OTTHUMG00000151129
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FLJ41942; DKFZp434C2422; DKFZp779C1668
Summary: The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 22q12.1

Sequence :: Chromosome: 22; NC_000022.10 (26138120..26427007)

See MYO18B in Epigenomics, MapViewer

Chromosome 22 - NC_000022.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
The restored expression of MYO18B may be a useful therapeutic strategy for the treatment of locally advanced Malignant pleural mesothelioma(MPM)in humans.
Title: Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice.
MYO18B alterations, including both epigenetic and genetic alterations, play an important role in ovarian carcinogenesis
Title: Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer.
Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation
Title: Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation.
candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer
Title: MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer.
Proteasome dysfunction by a proteasome inhibitor or siRNA-mediated knock-down of Sug1 caused the up-regulation of MYO18B protein and MYO18B was polyubiquitinated in vivo.
Title: MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

A genome-wide association study of serum uric acid in African Americans.

Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.

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Products	Interactant	Other Gene	Source	Pubs	Description
Q8IUG5	P60709	ACTB	HPRD	PubMed
Q8IUG5	P62195	PSMC5	HPRD	PubMed
BioGRID:124214	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
actin binding	IEA Inferred from Electronic Annotation more info
motor activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
sarcomere	IEA Inferred from Electronic Annotation more info
unconventional myosin complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: unconventional myosin-XVIIIb

Names: unconventional myosin-XVIIIb; myosin 18B; myosin-XVIIIb

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032608.5 → NP_115997.5 unconventional myosin-XVIIIb

Status: REVIEWED

Source sequence(s)

AB075376, AJ310931

Consensus CDS

CCDS54507.1

UniProtKB/TrEMBL

F5GYU7

UniProtKB/Swiss-Prot

Q8IUG5

Related

ENSP00000334563, OTTHUMP00000198632, ENST00000335473, OTTHUMT00000320371

Conserved Domains (5) summary

cd01386
Location:572 – 1332
Blast Score: 2960

MYSc_type_XVIII; Myosin motor domain, type XVIII myosins. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and ...

COG1196
Location:1798 – 2096
Blast Score: 112

Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]

pfam01576
Location:1421 – 1918
Blast Score: 202

Myosin_tail_1; Myosin tail

TIGR00927
Location:221 – 513
Blast Score: 101

2A1904; K+-dependent Na+/Ca+ exchanger

smart00242
Location:566 – 1333
Blast Score: 806

MYSc; Myosin. Large ATPases.

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000022.10 Reference GRCh37.p5 Primary Assembly

Range

26138120..26427007

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000154.1 Alternate HuRef

Range

9085589..9374875

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AJ310932.1	CAC70714.3
genomic	AL022329.9	CAQ09178.1
genomic	AL079300.11	CAQ09046.1
genomic	AL080245.14	CAQ07158.1
genomic	CH471095.1	EAW59702.1
		EAW59703.1
		EAW59704.1
		EAW59705.1
		EAW59706.1
		EAW59707.1
		EAW59708.1
genomic	Z98949.1	CAQ08575.1
mRNA	AB042648.2	BAB55550.2
mRNA	AB075376.1	BAC16363.1
mRNA	AJ271918.1	CAC81082.1
mRNA	AJ310931.2	CAC70712.2
mRNA	AK095943.1	BAC04656.1
mRNA	AK123936.1	None
mRNA	AL833890.1	CAD38746.1
mRNA	AY077700.1	AAL75811.1
mRNA	BC144596.1	None
mRNA	BC144597.1	AAI44598.1
mRNA	BC150626.1	AAI50627.1
mRNA	CR749556.1	CAH18353.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q68D67	GenPept	UniProtKB/TrEMBL:Q68D67
Q8IUG5.1	GenPept	UniProtKB/Swiss-Prot:Q8IUG5
Q8N903	GenPept	UniProtKB/TrEMBL:Q8N903