CAT catalase [Homo sapiens] - Gene

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Summary

Official Symbol: CATprovided by HGNC
Official Full Name: catalaseprovided by HGNC
Primary source: HGNC:1516
See related: Ensembl:ENSG00000121691; HPRD:00282; MIM:115500; Vega:OTTHUMG00000044353
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MGC138422; MGC138424
Summary: This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]

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Genomic context

Location :: 11p13

Sequence :: Chromosome: 11; NC_000011.9 (34460472..34493607)

See CAT in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Histone H4 deacetylation down-regulates catalase gene expression in doxorubicin-resistant AML subline.
Title: Histone H4 deacetylation down-regulates catalase gene expression in doxorubicin-resistant AML subline.
increased activity correlates with disease progression in pneumoconiosis patients
Title: [Functional state of RBC and neutrophils in pneumoconiosis patients variable in tolerance to dust factor in after contact period].
The catalase-like oxygen production by human methemoglobin in the presence of H(2)O(2) was kinetically characterized with a Clark-type electrode.
Title: Catalase-like activity of human methemoglobin: a kinetic and mechanistic study.
interaction of PEX5 with catalase and PEX14
Title: PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14.
In CAT-21A/T and GPX1-198C/T polymorphisms, there were no significant differences in the variant homozygous frequencies in patients compared to controls.
Title: Genetic polymorphisms of superoxide dismutases, catalase, and glutathione peroxidase in age-related cataract.
The levels of SOD and CAT activity were significantly related to adult asthma.
Title: The association between adult asthma and superoxide dismutase and catalase gene activity.
genetic polymorophism affects the efficiency of renutrition in malnourished elderly patients
Title: Catalase rs769214 SNP in elderly malnutrition and during renutrition: is glucagon to blame?
we concluded that CAT TC exon 9 polymorphism may play an important role in vitiligo disease development and may serve as a genetic marker of vitiligo risk.
Title: The polymorphism of catalase T/C codon 389 in exon 9 and vitiligo susceptibility: a meta-analysis.
Oct-1 is downregulated by reactive oxygen species via CpG island methylation in its promoter
Title: Reactive oxygen species downregulate catalase expression via methylation of a CpG island in the Oct-1 promoter.
This study assessed the influence of catalase overexpression on the sensitivity of breast cancer cells towards various anticancer treatments.
Title: Catalase overexpression in mammary cancer cells leads to a less aggressive phenotype and an altered response to chemotherapy.

Submit: New GeneRIF Correction See all (119)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	Free radical scavengers such as superoxide dismutase (SOD), dimethylthiourea (DMTU) and catalase attenuate morphine and gp160-induced human monocyte apoptosis	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001743.1	NP_002825.3	PTPN11	BIND	PubMed	Cat interacts with Shp-2.
P04040	P42684	ABL2	HPRD	PubMed
P04040	P04040	CAT	HPRD	PubMed
P04040	Q06124	PTPN11	HPRD	PubMed
P04040	Q6EEV6	SUMO4	HPRD	PubMed
P04040	Q9BXR5	TLR10	HPRD	PubMed
BioGRID:107297	BioGRID:106543	ABL1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:107297	BioGRID:106545	ABL2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:107297	BioGRID:107297	CAT	BioGRID	PubMed	Co-crystal Structure
BioGRID:107297	BioGRID:111788	PEX5	BioGRID	PubMed	Two-hybrid
BioGRID:107297	BioGRID:132223	SUMO4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107297	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107297	BioGRID:120020	USP53	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
NADP binding	IDA Inferred from Direct Assay more info	PubMed
aminoacylase activity	IEA Inferred from Electronic Annotation more info
catalase activity	IDA Inferred from Direct Assay more info	PubMed
catalase activity	TAS Traceable Author Statement more info
heme binding	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
oxidoreductase activity, acting on peroxide as acceptor	ISS Inferred from Sequence or Structural Similarity more info
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
UV protection	IMP Inferred from Mutant Phenotype more info	PubMed
aerobic respiration	IEA Inferred from Electronic Annotation more info
aging	IEA Inferred from Electronic Annotation more info
cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
hemoglobin metabolic process	IEA Inferred from Electronic Annotation more info
hydrogen peroxide catabolic process	IDA Inferred from Direct Assay more info	PubMed
menopause	IEA Inferred from Electronic Annotation more info
negative regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
nucleobase-containing small molecule metabolic process	TAS Traceable Author Statement more info
positive regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info
positive regulation of cell division	IEA Inferred from Electronic Annotation more info
positive regulation of phosphatidylinositol 3-kinase cascade	IEA Inferred from Electronic Annotation more info
protein tetramerization	IDA Inferred from Direct Assay more info	PubMed
purine base metabolic process	TAS Traceable Author Statement more info
purine nucleotide catabolic process	TAS Traceable Author Statement more info
response to hyperoxia	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
response to vitamin E	IEA Inferred from Electronic Annotation more info
small molecule metabolic process	TAS Traceable Author Statement more info
triglyceride metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
cytosol	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
lysosome	IEA Inferred from Electronic Annotation more info
mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
mitochondrion	IEA Inferred from Electronic Annotation more info
peroxisomal matrix	TAS Traceable Author Statement more info
peroxisomal membrane	ISS Inferred from Sequence or Structural Similarity more info
peroxisome	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: catalase

Names: catalase

NP_001743.1

EC 1.11.1.6

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013339.1 RefSeqGene

Range

5001..38136

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001752.3 → NP_001743.1 catalase

Status: REVIEWED

Source sequence(s)

AK291585, AL035079, AW023382

Consensus CDS

CCDS7891.1

UniProtKB/Swiss-Prot

P04040

Related

ENSP00000241052, OTTHUMP00000041455, ENST00000241052, OTTHUMT00000103197

Conserved Domains (2) summary

COG0753
Location:17 – 505
Blast Score: 1666

KatE; Catalase [Inorganic ion transport and metabolism]

cd08156
Location:68 – 497
Blast Score: 2281

catalase_clade_3; Clade 3 of the heme-binding enzyme catalase

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p5 Primary Assembly

Range

34460472..34493607

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

34157829..34190968

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL035079.14	CAB45236.1
genomic	AY545477.1	AAS37679.1
genomic	CH471064.2	EAW68170.1
		EAW68171.1
genomic	K02400.1	AAB59522.1
genomic	L13609.1	AAA16651.1
genomic	X04085.1	CAA27721.1
genomic	X04096.1	None
mRNA	AK291585.1	BAF84274.1
mRNA	AK301577.1	BAG63070.1
mRNA	AK310184.1	None
mRNA	AK315350.1	BAG37746.1
mRNA	AW023382.1	None
mRNA	AY028632.1	AAK29181.1
mRNA	BC027300.1	AAH27300.1
mRNA	BC110398.1	AAI10399.1
mRNA	BC112217.1	AAI12218.1
mRNA	BC112219.1	AAI12220.1
mRNA	BI551632.1	None
mRNA	CA748580.1	None
mRNA	X04076.1	CAA27717.1
other-genetic	HQ258304.1	ADR83058.1