PPP1R9B protein phosphatase 1, regulatory subunit 9B [Homo sapiens] - Gene

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Summary

Official Symbol: PPP1R9Bprovided by HGNC
Official Full Name: protein phosphatase 1, regulatory subunit 9Bprovided by HGNC
Primary source: HGNC:9298
See related: HPRD:04506; MIM:603325
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Spn; SPINO; PPP1R6; PPP1R9; FLJ30345
Summary: Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997 [PubMed 9275233]).[supplied by OMIM, Mar 2008]

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Genomic context

Location :: 17q21.33

Sequence :: Chromosome: 17; NC_000017.10 (48211101..48227877, complement)

See PPP1R9B in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The molecular size and subcellular location of myotube glycogen particles is determined by the PPP1R6, PTG and G(M) scaffolding.
Title: Differential pattern of glycogen accumulation after protein phosphatase 1 glycogen-targeting subunit PPP1R6 overexpression, compared to PPP1R3C and PPP1R3A, in skeletal muscle cells.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association study of 182 candidate genes in anorexia nervosa.
IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1
Title: Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1).
Asef2, Neurabin2 and APC cooperatively regulate actin cytoskeletal organization and are required for HGF-induced cell migration.
Title: Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.
PPP1R9B is required for synapse formation in the NK cells and suggest that it may be involved in the maintenance of cellular architecture by regulation of actin assembly, possibly acting to stabilize the NKIS until granule release is eminent.
Title: PPP1R9B (Neurabin 2): involvement and dynamics in the NK immunological synapse.
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Title: Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Decreased spinophilin but unchanged MAP2 expression provides molecular evidence for a hippocampal dendritic pathology in schizophrenia that preferentially affects the spines.
Title: Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines.
The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines.
Title: The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_115984.1	NP_478102.1	CDKN2A	BIND	PubMed	SPINO interacts with p14ARF.
Q96SB3	P35348	ADRA1A	HPRD	PubMed
Q96SB3	Q8N726	CDKN2A	HPRD	PubMed
Q96SB3	O43602	DCX	HPRD	PubMed
Q96SB3	P14416	DRD2	HPRD	PubMed
Q96SB3	P28482	MAPK1	HPRD	PubMed
Q96SB3	P62136	PPP1CA	HPRD	PubMed
Q96SB3	P41236	PPP1R2	HPRD	PubMed
Q96SB3	Q9ULJ8	PPP1R9A	HPRD	PubMed
Q96SB3	P17612	PRKACA	HPRD	PubMed
Q96SB3	P23443	RPS6KB1	HPRD	PubMed
Q96SB3	O43493	TGOLN2	HPRD	PubMed
Q96SB3	Q13009	TIAM1	HPRD	PubMed
BioGRID:124202	BioGRID:106573	ACTA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:124202	BioGRID:106659	ADRA2A	BioGRID	PubMed	Reconstituted Complex
BioGRID:124202	BioGRID:106660	ADRA2B	BioGRID	PubMed	Reconstituted Complex
BioGRID:124202	BioGRID:106661	ADRA2C	BioGRID	PubMed	Reconstituted Complex
BioGRID:124202	BioGRID:107463	CDKN2A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:124202	BioGRID:108147	DRD2	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:124202	BioGRID:111493	PPP1CA	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:124202	BioGRID:111494	PPP1CB	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:124202	BioGRID:111495	PPP1CC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:124202	BioGRID:111497	PPP1R2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:124202	BioGRID:111858	RASGRF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:124202	BioGRID:112930	TIAM1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:124202	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:124202	BioGRID:122327	USP46	BioGRID	PubMed	Affinity Capture-MS
BioGRID:124202	BioGRID:121649	WDR48	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
actin binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein phosphatase 1 binding	NAS Non-traceable Author Statement more info	PubMed
protein phosphatase inhibitor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
RNA splicing	NAS Non-traceable Author Statement more info	PubMed
cell cycle arrest	TAS Traceable Author Statement more info	PubMed
cell differentiation	IEA Inferred from Electronic Annotation more info
cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to morphine	ISS Inferred from Sequence or Structural Similarity more info
filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
nervous system development	IEA Inferred from Electronic Annotation more info
regulation of cell growth by extracellular stimulus	TAS Traceable Author Statement more info	PubMed
regulation of cell proliferation	NAS Non-traceable Author Statement more info	PubMed
regulation of exit from mitosis	NAS Non-traceable Author Statement more info	PubMed
regulation of opioid receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
adherens junction	IEA Inferred from Electronic Annotation more info
cell junction	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoskeleton	IEA Inferred from Electronic Annotation more info
dendritic spine	IEA Inferred from Electronic Annotation more info
filopodium	IDA Inferred from Direct Assay more info	PubMed
lamellipodium	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
protein phosphatase type 1 complex	TAS Traceable Author Statement more info	PubMed
ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
synapse	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: neurabin-2

Names: neurabin-2; neurabin II; neurabin-II; spinophilin; protein phosphatase 1, regulatory (inhibitor) subunit 9B; protein phosphatase 1, regulatory subunit 9B, spinophilin

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032595.3 → NP_115984.3 neurabin-2

Status: VALIDATED

Source sequence(s)

AI056581, AJ401189, AL157449, AL713642, BF109903

UniProtKB/TrEMBL

D3DTX6

UniProtKB/Swiss-Prot

Q96SB3

Conserved Domains (2) summary

cd00992
Location:497 – 580
Blast Score: 159

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02168
Location:649 – 812
Blast Score: 147

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

48211101..48227877, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

43578978..43595756, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC002401.2 (5038..20216)	None
genomic	CH471109.2	EAW94636.1
		EAW94637.1
		EAW94638.1
mRNA	AI056581.1	None
mRNA	AJ401189.1	CAC37685.1
mRNA	AK054907.1	BAG51442.1
mRNA	AL157449.1	None
mRNA	AL713642.1	CAD28455.2
mRNA	BC008564.1	AAH08564.1
mRNA	BC011232.1	None
mRNA	BC016162.1	AAH16162.1
mRNA	BF109903.1	None
mRNA	CB052174.1	None

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q96B17	GenPept	UniProtKB/TrEMBL:Q96B17
Q96HI8	GenPept	UniProtKB/TrEMBL:Q96HI8
Q96SB3.2	GenPept	UniProtKB/Swiss-Prot:Q96SB3