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Cox4i2 cytochrome c oxidase subunit IV isoform 2 [ Mus musculus (house mouse) ]

Gene ID: 84682, updated on 21-May-2016
Official Symbol
Cox4i2provided by MGI
Official Full Name
cytochrome c oxidase subunit IV isoform 2provided by MGI
Primary source
MGI:MGI:2135755
See related
Ensembl:ENSMUSG00000009876 Vega:OTTMUSG00000015832
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cox4b; CoxIV-2
Orthologs
Location:
2; 2 H2
Exon count:
5
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (152754173..152765037)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (152579909..152590773)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene inhibitor of DNA binding 1 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene predicted gene, 32057 Neighboring gene BCL2-like 1 Neighboring gene predicted gene, 32211 Neighboring gene TPX2, microtubule-associated Neighboring gene microRNA 5622

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Alzheimer's disease, organism-specific biosystem (from KEGG)
    Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimer's disease, conserved biosystem (from KEGG)
    Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
    Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Cardiac muscle contraction, conserved biosystem (from KEGG)
    Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Cytochrome c oxidase, organism-specific biosystem (from KEGG)
    Cytochrome c oxidase, organism-specific biosystemStructural complex; Energy metabolism; ATP synthesis
  • Cytochrome c oxidase, conserved biosystem (from KEGG)
    Cytochrome c oxidase, conserved biosystemStructural complex; Energy metabolism; ATP synthesis
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Oxidative phosphorylation, organism-specific biosystem (from KEGG)
    Oxidative phosphorylation, organism-specific biosystem
    Oxidative phosphorylation
  • Oxidative phosphorylation, conserved biosystem (from KEGG)
    Oxidative phosphorylation, conserved biosystem
    Oxidative phosphorylation
  • Parkinson's disease, organism-specific biosystem (from KEGG)
    Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
cytochrome-c oxidase activity ISA
Inferred from Sequence Alignment
more info
PubMed 
cytochrome-c oxidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrial respiratory chain complex IV ISA
Inferred from Sequence Alignment
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Names
Cox IV-2
cytochrome c oxidase, subunit IVb

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053091.2NP_444321.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_444321.1

    Status: PROVISIONAL

    Source sequence(s)
    AL731857
    Consensus CDS
    CCDS16898.1
    UniProtKB/Swiss-Prot
    Q91W29
    Related
    ENSMUSP00000010020, OTTMUSP00000016874, ENSMUST00000010020, OTTMUST00000037638
    Conserved Domains (1) summary
    cd00922
    Location:41165
    Cyt_c_Oxidase_IV; Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    152754173..152765037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    158570176..158581023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)