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    SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 [ Homo sapiens ]

    Gene ID: 8467, updated on 11-May-2012

    Summary

    Official Symbol
    SMARCA5provided by HGNC
    Official Full Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5provided by HGNC
    Primary source
    HGNC:11101
    See related
    Ensembl:ENSG00000153147; HPRD:04538; MIM:603375; Vega:OTTHUMG00000161474
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ISWI; SNF2H; hISWI; hSNF2H; WCRF135
    Summary
    The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    4q31.1-q31.2
    Sequence :
    Chromosome: 4; NC_000004.11 (144434616..144478642)
    See SMARCA5 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene 20 Neighboring gene GRB2-associated binding protein 1 Neighboring gene ribosomal protein SA pseudogene 36 Neighboring gene SMARCA5 antisense RNA 1 (non-protein coding) Neighboring gene uncharacterized LOC100652877 Neighboring gene glucuronidase, beta pseudogene 5 Neighboring gene FRAS1 related extracellular matrix 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_003592.2 NC_000003.9 ALB    BIND  PubMed SNF2H interacts with the Albumin gene. 
    NP_003592.2 BAZ1A    BIND  PubMed SNF2H interacts with hACF1. 
    NP_003592.2 DNMT3B    BIND  PubMed DNMT3B interacts with hSNF2H. 
    NP_003592.2 NP_002098.1 H3F3A    BIND  PubMed H3F3A (Histone 3) interacts with SMARCA5 (SNF2H). 
    NP_003592.2 NP_001518.1 HDAC2    BIND  PubMed SMARCA5 (SNF2h) interacts with HDAC2. 
    NP_003592.2 NC_000012.9 HNF1A    BIND  PubMed SNF2H interacts with the HNF-1 gene. 
    NP_003592.2     BIND  PubMed SNF2H interacts and hydrolyses ATP. 
    O60264 Q9NRL2 BAZ1A    HPRD  PubMed  
    O60264 Q9UIG0 BAZ1B    HPRD  PubMed  
    O60264 Q9UIF9 BAZ2A    HPRD  PubMed  
    O60264 Q9NRG0 CHRAC1    HPRD  PubMed  
    O60264 P16220 CREB1    HPRD  PubMed  
    O60264 Q9UBC3 DNMT3B    HPRD  PubMed  
    O60264 P84243 H3F3B    HPRD  PubMed  
    O60264 Q92769 HDAC2    HPRD  PubMed  
    O60264 P62805 HIST2H4A    HPRD  PubMed  
    O60264 O75444 MAF    HPRD  PubMed  
    O60264 O60216 RAD21    HPRD  PubMed  
    O60264 Q96T23 RSF1    HPRD  PubMed  
    O60264 Q01826 SATB1    HPRD  PubMed  
    BioGRID:114045 BioGRID:116347 BAZ1A    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex 
    BioGRID:114045 BioGRID:114497 BAZ1B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation 
    BioGRID:114045 BioGRID:116346 BAZ2A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114045 BioGRID:198359 Bmi1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114045 BioGRID:123555 CDT1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114045 BioGRID:118176 CECR2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114045 BioGRID:107487 CENPA    BioGRID  PubMed Co-purification 
    BioGRID:114045 BioGRID:107532 CHD3    BioGRID  PubMed Co-purification 
    BioGRID:114045 BioGRID:119904 CHRAC1    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:114045 BioGRID:107775 CREB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114045 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:114045 BioGRID:198535 Cbx2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114045 BioGRID:108123 DNMT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114045 BioGRID:108126 DNMT3B    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:114045 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western; Co-localization; Co-purification 
    BioGRID:114045 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114045 BioGRID:113946 HIST1H3A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114045 BioGRID:113955 HIST1H4A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114045 BioGRID:130469 HIST2H2AB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114045 BioGRID:110269 MAF    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114045 BioGRID:110340 MCM3    BioGRID  PubMed Co-localization 
    BioGRID:114045 BioGRID:115770 MYBBP1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114045 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114045 BioGRID:110725 MYO1C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114045 BioGRID:119903 POLE3    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:114045 BioGRID:117396 POLR1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114045 BioGRID:111822 RAD21    BioGRID  PubMed Co-purification 
    BioGRID:114045 BioGRID:111863 RBBP4    BioGRID  PubMed Co-purification 
    BioGRID:114045 BioGRID:119724 RSF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114045 BioGRID:112211 SATB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114045 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114045 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114045 BioGRID:113871 SMC1A    BioGRID  PubMed Co-purification 
    BioGRID:114045 BioGRID:114574 SMC3    BioGRID  PubMed Co-purification 
    BioGRID:114045 BioGRID:112540 SOX2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114045 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114045 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114045 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114045 BioGRID:113190 UBTF    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114045 BioGRID:113237 USF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114045 BioGRID:113353 XRCC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114045 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 

    General gene information

    Markers

    Homology

    • Homologs of the SMARCA5 gene: The SMARCA5 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, , , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
     
    nucleosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ATP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP-dependent chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    CenH3-containing nucleosome assembly at centromere TAS
    Traceable Author Statement
    more info
     
    chromatin assembly or disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin silencing at rDNA IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
     
    embryo development IEA
    Inferred from Electronic Annotation
    more info
     
    nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleosome assembly TAS
    Traceable Author Statement
    more info
     
    nucleosome positioning IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription initiation, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    NURF complex IDA
    Inferred from Direct Assay
    more info
     
    RSF complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromatin silencing complex IEA
    Inferred from Electronic Annotation
    more info
     
    condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with nuclear replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
    Names
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
    sucrose nonfermenting-like 5
    sucrose nonfermenting protein 2 homolog
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003601.3NP_003592.3  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

      Status: REVIEWED

      Source sequence(s)
      AB010882, AC139713, AK123439, AU132439
      Consensus CDS
      CCDS3761.1
      UniProtKB/Swiss-Prot
      O60264
      Related
      ENSP00000283131, OTTHUMP00000220293, ENST00000283131, OTTHUMT00000365077
      Conserved Domains (7) summary
      cd00046
      Location:200339
      Blast Score: 220
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:474605
      Blast Score: 259
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00167
      Location:844883
      Blast Score: 93
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      COG0513
      Location:482743
      Blast Score: 109
      SrmB; Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]
      pfam00176
      Location:183463
      Blast Score: 997
      SNF2_N; SNF2 family N-terminal domain
      pfam09110
      Location:743820
      Blast Score: 200
      HAND; HAND
      pfam09111
      Location:8981008
      Blast Score: 423
      SLIDE; SLIDE

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      144434616..144478642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      140164707..140208721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC099396.5 AAY40920.1
    genomic AC104685.2 AAY40965.1
    genomic AC139713.1 None
    genomic CH471056.2 EAX05071.1
    mRNA AB010882.1 BAA25173.1
    mRNA AF086544.1 None
    mRNA AK123439.1 None
    mRNA AK302841.1 BAG64032.1
    mRNA AK308424.1 None
    mRNA AK316444.1 BAH14815.1
    mRNA AL157495.1 None
    mRNA AU132439.1 None
    mRNA BC023144.1 AAH23144.1
    other-genetic JF432501.1 ADZ15718.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60264.1 GenPept UniProtKB/Swiss-Prot:O60264
    Q4W5G3 GenPept UniProtKB/TrEMBL:Q4W5G3
    Q4W5H1 GenPept UniProtKB/TrEMBL:Q4W5H1

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