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    USP32 ubiquitin specific peptidase 32 [ Homo sapiens ]

    Gene ID: 84669, updated on 11-May-2012

    Summary

    Official Symbol
    USP32provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 32provided by HGNC
    Primary source
    HGNC:19143
    See related
    Ensembl:ENSG00000170832; HPRD:07612; MIM:607740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    USP10; NY-REN-60

    Genomic context

    Location :
    17q23.3
    Sequence :
    Chromosome: 17; NC_000017.10 (58254691..58469586, complement)
    See USP32 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene adaptor-related protein complex 1, sigma 2 subunit pseudogene Neighboring gene carbonic anhydrase IV Neighboring gene small Cajal body-specific RNA 20 Neighboring gene septin 7 pseudogene Neighboring gene ribosomal protein L32 pseudogene 32 Neighboring gene uncharacterized LOC100506882 Neighboring gene chromosome 17 open reading frame 64

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:124189 BioGRID:111783 ABCD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:107420 CDK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:116704 ERP44    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:108487 FARSA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:110073 KRT18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:110078 KRT19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:110054 KRT8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:121540 LRRC47    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:119918 MRPL39    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:113871 SMC1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:114730 TRIP13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:113603 TUBA1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:119239 UBXN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:128649 USP32P2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:113221 USP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:114552 USP6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:120855 VPS35    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124189 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin thiolesterase activity IDA
    Inferred from Direct Assay
    more info
     
    Process Evidence Code Pubs
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 32
    Names
    ubiquitin carboxyl-terminal hydrolase 32
    ubiquitin thioesterase 32
    deubiquitinating enzyme 32
    ubiquitin thiolesterase 32
    ubiquitin specific protease 32
    renal carcinoma antigen NY-REN-60
    ubiquitin-specific-processing protease 32
    NP_115971.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032582.3NP_115971.2  ubiquitin carboxyl-terminal hydrolase 32

      Status: VALIDATED

      Source sequence(s)
      AF533230, AL834444, BI459907
      Consensus CDS
      CCDS32697.1
      UniProtKB/Swiss-Prot
      Q8NFA0
      Related
      ENSP00000300896, ENST00000300896
      Conserved Domains (4) summary
      cd00051
      Location:237293
      Blast Score: 105
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      COG5126
      Location:189339
      Blast Score: 138
      FRQ1; Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]
      cl02553
      Location:12251318
      Blast Score: 260
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cl12116
      Location:517586
      Blast Score: 141
      DUSP; DUSP domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      58254691..58469586, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      53625587..53839800, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC003962.1 (78389..101369) None
    genomic AC025048.8 (126732..137920) None
    genomic AC037475.9 (71463..113927) None
    genomic AC104763.12 (25157..163417) None
    genomic AY163319.1 AAO21353.1
    genomic CH471109.2 EAW94356.1
      EAW94357.1
      EAW94358.1
    mRNA AF155116.1 AAD42882.1
    mRNA AF350251.1 AAK30207.1
    mRNA AF533230.1 AAM97922.1
    mRNA AK057301.1 None
    mRNA AK091680.1 None
    mRNA BC054344.1 AAH54344.1
    mRNA BC070497.1 AAH70497.1
    mRNA BC094680.1 AAH94680.1
    mRNA BI459907.1 None
    other-genetic BC156264.1 AAI56265.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VC15 GenPept UniProtKB/TrEMBL:Q4VC15
    Q6IRT0 GenPept UniProtKB/TrEMBL:Q6IRT0
    Q7Z5T3 GenPept UniProtKB/TrEMBL:Q7Z5T3
    Q86WP5 GenPept UniProtKB/TrEMBL:Q86WP5
    Q8NFA0.1 GenPept UniProtKB/Swiss-Prot:Q8NFA0

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