Format

Send to:

Choose Destination

ADGRE3 adhesion G protein-coupled receptor E3 [ Homo sapiens (human) ]

Gene ID: 84658, updated on 7-May-2016
Official Symbol
ADGRE3provided by HGNC
Official Full Name
adhesion G protein-coupled receptor E3provided by HGNC
Primary source
HGNC:HGNC:23647
See related
Ensembl:ENSG00000131355 HPRD:07309; MIM:606101; Vega:OTTHUMG00000183406
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EMR3
Summary
This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
Orthologs
Location:
19p13.1
Exon count:
16
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (14619117..14674918, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14730051..14785730, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit B7 Neighboring gene C-type lectin domain family 17 member A Neighboring gene integrin subunit beta 1 pseudogene 1 Neighboring gene zinc finger protein 333 Neighboring gene adhesion G protein-coupled receptor E2 Neighboring gene transmembrane protein 167A pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of egf-like module containing, mucin-like, hormone receptor-like 3 (EMR3) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
adhesion G protein-coupled receptor E3
Names
EGF-like module receptor 3
EGF-like module-containing mucin-like hormone receptor-like 3
egf-like module containing, mucin-like, hormone receptor-like 3
egf-like module-containing mucin-like receptor 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289158.1NP_001276087.1  adhesion G protein-coupled receptor E3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001276087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AF239764, AK298653, AL832663, AY358817, BC128053
    Consensus CDS
    CCDS74297.1
    UniProtKB/Swiss-Prot
    Q9BY15
    UniProtKB/TrEMBL
    A1L1B9, B7Z5A1
    Related
    ENSP00000340758, ENST00000344373
    Conserved Domains (3) summary
    pfam01825
    Location:252293
    GPS; Latrophilin/CL-1-like GPS domain
    pfam09402
    Location:2091
    MSC; Man1-Src1p-C-terminal domain
    cl21587
    Location:301542
    7tm_2; 7 transmembrane receptor (Secretin family)
  2. NM_001289159.1NP_001276088.1  adhesion G protein-coupled receptor E3 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks three alternate in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AF239764, AK298653, AL832663, BC128053
    Consensus CDS
    CCDS74296.1
    UniProtKB/Swiss-Prot
    Q9BY15
    UniProtKB/TrEMBL
    A1L1B9, B7Z5A1, E7EW83
    Related
    ENSP00000396208, OTTHUMP00000271611, ENST00000443157, OTTHUMT00000466486
    Conserved Domains (2) summary
    pfam01825
    Location:178219
    GPS; Latrophilin/CL-1-like GPS domain
    cl21587
    Location:227468
    7tm_2; 7 transmembrane receptor (Secretin family)
  3. NM_032571.4NP_115960.2  adhesion G protein-coupled receptor E3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_115960.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF239764, AK298653, AL832663, BC121130, BC128053
    Consensus CDS
    CCDS12315.1
    UniProtKB/Swiss-Prot
    Q9BY15
    UniProtKB/TrEMBL
    A1L1B9, B7Z5A1, Q0IJ53
    Related
    ENSP00000253673, OTTHUMP00000271613, ENST00000253673, OTTHUMT00000466488
    Conserved Domains (3) summary
    cd00054
    Location:67104
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01825
    Location:304345
    GPS; Latrophilin/CL-1-like GPS domain
    cl21587
    Location:353594
    7tm_2; 7 transmembrane receptor (Secretin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    14619117..14674918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528374.1XP_011526676.1  

    Conserved Domains (3) summary
    cd00054
    Location:5087
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01825
    Location:287328
    GPS; Latrophilin/CL-1-like GPS domain
    cl21587
    Location:336577
    7tm_2; 7 transmembrane receptor (Secretin family)
  2. XM_005260118.1XP_005260175.1  

    Conserved Domains (2) summary
    cd00054
    Location:67104
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl21587
    Location:324528
    7tm_2; 7 transmembrane receptor (Secretin family)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    14731086..14785249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152939.1: Suppressed sequence

    Description
    NM_152939.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.