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    TEAD2 TEA domain family member 2 [ Homo sapiens ]

    Gene ID: 8463, updated on 11-May-2012
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    Summary

    Official Symbol
    TEAD2provided by HGNC
    Official Full Name
    TEA domain family member 2provided by HGNC
    Primary source
    HGNC:11715
    See related
    Ensembl:ENSG00000074219; MIM:601729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ETF; TEF4; TEF-4; TEAD-2
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    Genomic context

    Location :
    19q13.3
    Sequence :
    Chromosome: 19; NC_000019.9 (49843852..49865714, complement)
    See TEAD2 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene SUMO1 pseudogene 4 Neighboring gene solute carrier family 6, member 16 Neighboring gene microRNA 4324 Neighboring gene CD37 molecule Neighboring gene dickkopf-like 1 Neighboring gene coiled-coil domain containing 155 Neighboring gene uncharacterized LOC100505928

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086.
    3. Structural and functional analysis of the YAP-binding domain of human TEAD2. Tian W, et al. Proc Natl Acad Sci U S A, 2010 Apr 20. PMID 20368466.
    4. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud A, et al. Mol Syst Biol, 2009. PMID 19953087.
    5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.

    See all (15) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    3. structural and functional analysis of the YAP-binding domain of human TEAD2
      Title: Structural and functional analysis of the YAP-binding domain of human TEAD2.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q15562 Q15788 NCOA1    HPRD  PubMed  
    Q15562 P46937 YAP1    HPRD  PubMed  
    BioGRID:114041 BioGRID:114200 NCOA1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:114041 BioGRID:110811 NEDD4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114041 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114041 BioGRID:119544 VGLL1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
      PPARA Activates Gene Expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    • YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystem (from REACTOME)
      YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystemYAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 intera...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    sequence-specific distal enhancer binding RNA polymerase II transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    embryonic heart tube morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    hippo signaling cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lateral mesoderm development IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    neural tube closure IEA
    Inferred from Electronic Annotation
    more info
    		  
    notochord development IEA
    Inferred from Electronic Annotation
    more info
    		  
    paraxial mesoderm development IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    transcriptional enhancer factor TEF-4
    Names
    transcriptional enhancer factor TEF-4
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256658.1 → NP_001243587.1  transcriptional enhancer factor TEF-4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      BC007556, BC051301, BG334109
      UniProtKB/Swiss-Prot
      Q15562
      UniProtKB/TrEMBL
      Q8NA25
      Conserved Domains (1) summary
      cl02603
      Location:44 – 442
      Blast Score: 1207
      TEA; TEA/ATTS domain family

    2. NM_001256659.1 → NP_001243588.1  transcriptional enhancer factor TEF-4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK290736, BC007556, BG334109
      UniProtKB/Swiss-Prot
      Q15562
      UniProtKB/TrEMBL
      Q8NA25
      Conserved Domains (1) summary
      cl02603
      Location:44 – 442
      Blast Score: 1207
      TEA; TEA/ATTS domain family

    3. NM_001256660.1 → NP_001243589.1  transcriptional enhancer factor TEF-4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, contains an alternate exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is longer than isoform 1.
      Source sequence(s)
      AL832240, BC007556, BG334109
      UniProtKB/Swiss-Prot
      Q15562
      Conserved Domains (1) summary
      cl02603
      Location:44 – 443
      Blast Score: 1208
      TEA; TEA/ATTS domain family

    4. NM_001256661.1 → NP_001243590.1  transcriptional enhancer factor TEF-4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, contains an alternate exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is longer than isoform 1.
      Source sequence(s)
      BC007556, BC018803
      UniProtKB/Swiss-Prot
      Q15562
      Conserved Domains (1) summary
      cl02603
      Location:44 – 443
      Blast Score: 1208
      TEA; TEA/ATTS domain family

    5. NM_001256662.1 → NP_001243591.1  transcriptional enhancer factor TEF-4 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and has multiple differences in the coding region, including the use of a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK300241, BC007556, BG334109
      UniProtKB/TrEMBL
      B4DTJ6
      UniProtKB/Swiss-Prot
      Q15562
      Conserved Domains (1) summary
      cl02603
      Location:1 – 311
      Blast Score: 790
      TEA; TEA/ATTS domain family

    6. NM_003598.1 → NP_003589.1  transcriptional enhancer factor TEF-4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      BC007556
      Consensus CDS
      CCDS12761.1
      UniProtKB/Swiss-Prot
      Q15562
      Related
      ENSP00000310701, ENST00000311227
      Conserved Domains (1) summary
      cl02603
      Location:44 – 439
      Blast Score: 1209
      TEA; TEA/ATTS domain family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      49843852..49865714, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      46220662..46242282, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC010524.6 (1754..23616) None
    genomic CH471177.1 EAW52469.1
      EAW52470.1
      EAW52471.1
      EAW52472.1
      EAW52473.1
    mRNA AK093236.1 BAC04104.1
    mRNA AK290736.1 BAF83425.1
    mRNA AK300241.1 BAG62008.1
    mRNA AL832240.1 None
    mRNA BC007556.1 AAH07556.1
    mRNA BC018803.1 None
    mRNA BC051301.1 AAH51301.1
    mRNA BG334109.1 None
    mRNA X94440.1 CAA64214.1
    other-genetic DQ893163.2 ABM84089.1
    other-genetic DQ896460.2 ABM87459.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15562.2 GenPept UniProtKB/Swiss-Prot:Q15562
    Q8NA25 GenPept UniProtKB/TrEMBL:Q8NA25
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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