NTNG2 netrin G2 [Homo sapiens] - Gene

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Summary

Official Symbol: NTNG2provided by HGNC
Official Full Name: netrin G2provided by HGNC
Primary source: HGNC:14288
Locus tag: RP11-479K20.2
See related: Ensembl:ENSG00000196358; HPRD:17650; Vega:OTTHUMG00000020835
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Lmnt2; NTNG1; LHLL9381; bA479K20.1; KIAA0625; KIAA1857; MGC21884

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Genomic context

Location :: 9q34

Sequence :: Chromosome: 9; NC_000009.11 (135037334..135118220)

See NTNG2 in Epigenomics, MapViewer

Chromosome 9 - NC_000009.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the crystal structure for a fragment comprising the LN domain and domain LE1 of netrin G2 by sulfur single-wavelength anomalous diffraction phasing and refined it to 1.8 A resolution was determined.
Title: Crystal structure of the ligand binding domain of netrin G2.
Netrin-g2 is involved in the pathophysiology of epilepsy and are consistent with the hypothesis that this protein may participate in the abnormal development of synapses and in neuron migration
Title: Abnormal expression of netrin-G2 in temporal lobe epilepsy neurons in humans and a rat model.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.
The data of this stusty implicate NTNG2 in the pathophysiology of schizophrenia and bipolar disorder, but do not support the hypothesis that altered mRNA expression is the mechanism by which genetic variation of NTNG2 may confer disease susceptibility.
Title: Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder.
An association between NTNG2 and schizophrenia was observed with SNPs and haplotypes that clustered in the 5' region of the gene.
Title: A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Q96CW9	Q01844	EWSR1		HPRD	PubMed
BioGRID:124157	BioGRID:108431	EWSR1		BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
cell differentiation	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
nervous system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
anchored to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: netrin-G2

Names: netrin-G2; laminet 2; laminet-2; netrin G1; bA479K20.1 (novel protein)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032536.2 → NP_115925.2 netrin-G2 precursor

Status: VALIDATED

Source sequence(s)

AB058760, AF131842, AL159997

Consensus CDS

CCDS6946.1

UniProtKB/TrEMBL

O95898

UniProtKB/Swiss-Prot

Q96CW9

Related

ENSP00000376921, OTTHUMP00000022430, ENST00000393229, OTTHUMT00000054779

Conserved Domains (3) summary

cd00055
Location:408 – 446
Blast Score: 99

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:409 – 456
Blast Score: 111

Laminin_EGF; Laminin EGF-like (Domains III and V)

cl02806
Location:60 – 285
Blast Score: 303

Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000009.11 Reference GRCh37.p5 Primary Assembly

Range

135037334..135118220

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000141.1 Alternate HuRef

Range

104531594..104612230

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL159997.14	CAI40855.1
		CAI40856.1
genomic	AL353631.17	CAI16125.1
		CAI16126.1
genomic	CH471090.1	EAW87994.1
		EAW87995.1
		EAW87996.1
mRNA	AB058760.2	BAB47486.2
mRNA	AF131842.1	AAD20057.1
mRNA	AY358165.1	AAQ88532.1
mRNA	BC013770.1	AAH13770.1