Format

Send to:

Choose Destination

Hdac3 histone deacetylase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84578, updated on 8-May-2016
Official Symbol
Hdac3provided by RGD
Official Full Name
histone deacetylase 3provided by RGD
Primary source
RGD:619977
See related
Ensembl:ENSRNOG00000019618
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
mouse homolog plays an important role in regulating cell cycle progression [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Orthologs
Location:
18p11
Exon count:
16
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (31073057..31094347, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (30764344..30782387, complement)

Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene protocadherin gamma subfamily A, 1 Neighboring gene protocadherin gamma subfamily A, 2 Neighboring gene protocadherin gamma subfamily A, 3 Neighboring gene protocadherin gamma subfamily A, 5 Neighboring gene protocadherin gamma subfamily A, 7 Neighboring gene protocadherin gamma subfamily A, 8 Neighboring gene protocadherin gamma subfamily A, 9 Neighboring gene protocadherin gamma subfamily A, 10 Neighboring gene protocadherin gamma subfamily A, 11 Neighboring gene protocadherin gamma subfamily B, 7 Neighboring gene protocadherin gamma subfamily B, 8 Neighboring gene protocadherin gamma subfamily A, 12 Neighboring gene protocadherin gamma subfamily C, 3 Neighboring gene protocadherin gamma subfamily C, 5 Neighboring gene diaphanous-related formin 1 Neighboring gene FCH and double SH3 domains 1 Neighboring gene RELT-like 2 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
Inferred from Electronic Annotation
more info
 
NF-kappaB binding IEA
Inferred from Electronic Annotation
more info
 
NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cyclin binding IEA
Inferred from Electronic Annotation
more info
 
cyclin binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
cellular response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to fluid shear stress ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to parathyroid hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
histone H3 deacetylation IEA
Inferred from Electronic Annotation
more info
 
histone H3 deacetylation IEP
Inferred from Expression Pattern
more info
PubMed 
histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
histone deacetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle TAS
Traceable Author Statement
more info
 
negative regulation of interleukin-1 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT negative regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription factor import into nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription factor import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription factor import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of type B pancreatic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
regulation of protein stability IEA
Inferred from Electronic Annotation
more info
 
regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
regulation of protein stability ISS
Inferred from Sequence or Structural Similarity
more info
 
response to dexamethasone IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
spindle assembly IEA
Inferred from Electronic Annotation
more info
 
spindle assembly ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
spindle microtubule IEA
Inferred from Electronic Annotation
more info
 
spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
transcriptional repressor complex IEA
Inferred from Electronic Annotation
more info
 
transcriptional repressor complex ISO
Inferred from Sequence Orthology
more info
 
transcriptional repressor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
histone deacetylase 3
Names
HD3
NP_445900.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053448.1NP_445900.1  histone deacetylase 3

    See identical proteins and their annotated locations for NP_445900.1

    Status: PROVISIONAL

    Source sequence(s)
    AF321131
    UniProtKB/Swiss-Prot
    Q6P6W3
    Related
    ENSRNOP00000057161, ENSRNOT00000060417
    Conserved Domains (2) summary
    cd10005
    Location:3383
    HDAC3; Histone deacetylase 3 (HDAC3)
    PTZ00063
    Location:1397
    PTZ00063; histone deacetylase; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

    Range
    31073057..31094347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000086.1 Alternate Rn_Celera

    Range
    29414681..29434382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)