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FOXN1 forkhead box N1 [ Homo sapiens (human) ]

Gene ID: 8456, updated on 26-May-2016
Official Symbol
FOXN1provided by HGNC
Official Full Name
forkhead box N1provided by HGNC
Primary source
HGNC:HGNC:12765
See related
Ensembl:ENSG00000109101 HPRD:02907; MIM:600838; Vega:OTTHUMG00000132603
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WHN; RONU; FKHL20
Summary
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]
Orthologs
Location:
17q11.2
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (28506229..28538900)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26833249..26865175)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S7 pseudogene 1 Neighboring gene solute carrier family 13 member 2 Neighboring gene unc-119 lipid binding chaperone Neighboring gene phosphatidylinositol glycan anchor biosynthesis class S

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
T cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
hair follicle development IEA
Inferred from Electronic Annotation
more info
 
keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
lymphoid lineage cell migration into thymus IEA
Inferred from Electronic Annotation
more info
 
nail development IEA
Inferred from Electronic Annotation
more info
 
organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of hair follicle development IEA
Inferred from Electronic Annotation
more info
 
regulation of positive thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
thymus epithelium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
forkhead box protein N1
Names
Rowett nude
winged helix nude
winged-helix nude
winged-helix transcription factor nude

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007260.1 RefSeqGene

    Range
    5001..19217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_61

mRNA and Protein(s)

  1. NM_003593.2NP_003584.2  forkhead box protein N1

    See identical proteins and their annotated locations for NP_003584.2

    Status: REVIEWED

    Source sequence(s)
    Y11739
    Consensus CDS
    CCDS11232.1
    UniProtKB/Swiss-Prot
    O15353
    Related
    ENSP00000226247, OTTHUMP00000163432, ENST00000226247, OTTHUMT00000255832
    Conserved Domains (1) summary
    cd00059
    Location:271349
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    28506229..28538900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525361.1XP_011523663.1  

    See identical proteins and their annotated locations for XP_011523663.1

    UniProtKB/Swiss-Prot
    O15353
    Conserved Domains (1) summary
    cd00059
    Location:271349
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  2. XM_011525360.1XP_011523662.1  

    See identical proteins and their annotated locations for XP_011523662.1

    Conserved Domains (1) summary
    cd00059
    Location:272350
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  3. XM_011525358.1XP_011523660.1  

    See identical proteins and their annotated locations for XP_011523660.1

    Conserved Domains (1) summary
    cd00059
    Location:272350
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  4. XM_005258046.3XP_005258103.1  

    See identical proteins and their annotated locations for XP_005258103.1

    UniProtKB/Swiss-Prot
    O15353
    Related
    ENSP00000464645, OTTHUMP00000261126, ENST00000579795, OTTHUMT00000445709
    Conserved Domains (1) summary
    cd00059
    Location:271349
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  5. XM_011525368.1XP_011523670.1  

    See identical proteins and their annotated locations for XP_011523670.1

    Conserved Domains (1) summary
    cd00059
    Location:59137
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  6. XM_011525359.1XP_011523661.1  

    See identical proteins and their annotated locations for XP_011523661.1

    Conserved Domains (1) summary
    cd00059
    Location:272350
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  7. XM_011525362.1XP_011523664.1  

    Conserved Domains (1) summary
    cd00059
    Location:271349
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  8. XM_011525357.1XP_011523659.1  

    Conserved Domains (1) summary
    cd00059
    Location:283361
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  9. XM_011525365.1XP_011523667.1  

    Conserved Domains (1) summary
    cd00059
    Location:290368
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  10. XM_011525355.1XP_011523657.1  

    Conserved Domains (1) summary
    cd00059
    Location:289367
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  11. XM_011525354.1XP_011523656.1  

    Conserved Domains (1) summary
    cd00059
    Location:290368
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  12. XM_011525363.1XP_011523665.1  

    Conserved Domains (1) summary
    cd00059
    Location:290368
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  13. XM_011525356.1XP_011523658.1  

    Conserved Domains (1) summary
    cd00059
    Location:289367
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  14. XM_011525366.1XP_011523668.1  

    Conserved Domains (1) summary
    cd00059
    Location:90168
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  15. XM_011525364.1XP_011523666.1  

    Conserved Domains (1) summary
    cd00059
    Location:116194
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  16. XM_011525369.1XP_011523671.1  

    See identical proteins and their annotated locations for XP_011523671.1

    Conserved Domains (1) summary
    cd00059
    Location:59137
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  17. XM_011525370.1XP_011523672.1  

    See identical proteins and their annotated locations for XP_011523672.1

    Conserved Domains (1) summary
    cd00059
    Location:59137
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  18. XM_011525367.1XP_011523669.1  

    Conserved Domains (1) summary
    cd00059
    Location:85163
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    26912657..26926877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)