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    CUL1 cullin 1 [ Homo sapiens ]

    Gene ID: 8454, updated on 19-May-2012
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    Summary

    Official Symbol
    CUL1provided by HGNC
    Official Full Name
    cullin 1provided by HGNC
    Primary source
    HGNC:2551
    See related
    Ensembl:ENSG00000055130; HPRD:04389; MIM:603134; Vega:OTTHUMG00000152776
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGC149834; MGC149835
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    Genomic context

    Location :
    7q36.1
    Sequence :
    Chromosome: 7; NC_000007.13 (148395933..148498202)
    See CUL1 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene acyl-CoA thioesterase 13 pseudogene Neighboring gene chromosome 15 open reading frame 63 pseudogene Neighboring gene uncharacterized LOC100132884 Neighboring gene uncharacterized LOC100507558 Neighboring gene RNA, U7 small nuclear 20 pseudogene Neighboring gene enhancer of zeste homolog 2 (Drosophila) Neighboring gene RNA, Ro-associated Y4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mediator acts upstream of the transcriptional activator Gal4. Ang K, et al. PLoS Biol, 2012 Mar. PMID 22479149.
    2. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Altun M, et al. Chem Biol, 2011 Nov 23. PMID 22118674.
    3. FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Duan S, et al. Nature, 2012 Jan 5. PMID 22113614.
    4. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    5. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.

    See all (168) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. binding of Cul1-Rbx1 to Cul7-Rbx1 is mediated via heterodimerization of Fbxw8 with other F-box proteins which function to recruit substrates into the E3 ligase complex
      Title: Characterization of the Cullin7 E3 ubiquitin ligase--heterodimerization of cullin substrate receptors as a novel mechanism to regulate cullin E3 ligase activity.
    2. Association with CUL1 haplotype indicates a possible role of CUL1 variation(s) in rheumatoid arthritis and its response to methotrexate.
      Title: Association of Cullin1 haplotype variants with rheumatoid arthritis and response to methotrexate.
    3. The positive rates of ubiquitin and cul-1 were significantly higher in lung cancer than those in benign lesion tissues of the lung.
      Title: Expression of ubiquitin and cullin-1 and its clinicopathological significance in benign and malignant lesions of the lung.
    4. Our data indicated that Cullin1 may be an important marker for human gastric cancer lymph node metastasis and prognosis.
      Title: Overexpression of Cullin1 is associated with poor prognosis of patients with gastric cancer.
    5. Data show that CRN7 interacted with Cullin1 and Roc1 to form a novel SCF-like E3 complex.
      Title: Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob.
    6. The Cul1 expression is significantly correlated with melanoma development at early stages, implying targeting Cul1 may serve as a potential therapy for melanoma.
      Title: Cul1 expression is increased in early stages of human melanoma.
    7. Cul1 regulates melanoma cell growth and cell cycle progression through degradation of p27
      Title: Increased Cul1 expression promotes melanoma cell proliferation through regulating p27 expression.
    8. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
      Title: Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
    Submit: New GeneRIF Correction See all (28)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_003583.2 NP_689729.1 COMMD1    BIND  PubMed Murr1 interacts with Cul1 a component of the Cul1-Rbx1-Skp1-F Box Scf Ubiquitin Ligase complex. 
    NP_003583.2 NP_003583.2 CUL1    BIND  PubMed Cul1 [15-410] interacts with Cul1 [411-776] to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex. 
    NP_003583.2 NP_055063.1 RBX1    BIND  PubMed CUL1 interacts with ROC1. 
    NP_003583.2 NP_055063.1 RBX1    BIND  PubMed Rbx1 interacts with Cul1 [411-776] to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex. 
    NP_003583.2 NP_733779.1 SKP1    BIND  PubMed SKP1A interacts with Cul1 [15-410] to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex. 
    NP_003583.2 BAB87202.1 SKP2    BIND  PubMed Skp2-Fbox interacts with Cul1 [15-410] to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex. 
    Q13616 Q9Y297 BTRC    HPRD  PubMed  
    Q13616 Q86VP6 CAND1    HPRD  PubMed  
    Q13616 P49427 CDC34    HPRD  PubMed  
    Q13616 Cell division cycle associated 3 CDCA3    HPRD  PubMed  
    Q13616 P50750 CDK9    HPRD  PubMed  
    Q13616 O14757 CHEK1    HPRD  PubMed  
    Q13616 Q8N668 COMMD1    HPRD  PubMed  
    Q13616 Q7L5N1 COPS6    HPRD  PubMed  
    Q13616 Q13616 CUL1    HPRD  PubMed  
    Q13616 Q01094 E2F1    HPRD  PubMed  
    Q13616 Q8NFZ0 FBXO18    HPRD  PubMed  
    Q13616 Q8TCJ0 FBXO25    HPRD  PubMed  
    Q13616 Q9UKB1 FBXW11    HPRD  PubMed  
    Q13616 Q9UKT8 FBXW2    HPRD  PubMed  
    Q13616 P57775 FBXW4    HPRD  PubMed  
    Q13616 Q969H0 FBXW7    HPRD  PubMed  
    Q13616 Q13098 GPS1    HPRD  PubMed  
    Q13616 Q15843 NEDD8    HPRD  PubMed  
    Q13616 P25963 NFKBIA    HPRD  PubMed  
    Q13616 Q15653 NFKBIB    HPRD  PubMed  
    Q13616 O00221 NFKBIE    HPRD  PubMed  
    Q13616 Q14995 NR1D2    HPRD  PubMed  
    Q13616 P62136 PPP1CA    HPRD  PubMed  
    Q13616 O75400 PRPF40A    HPRD  PubMed  
    Q13616 P15153 RAC2    HPRD  PubMed  
    Q13616 P62877 RBX1    HPRD  PubMed  
    Q13616 Q9UBF6 RNF7    HPRD  PubMed  
    Q13616 P63208 SKP1    HPRD  PubMed  
    Q13616 Q13309 SKP2    HPRD  PubMed  
    Q13616 P84022 SMAD3    HPRD  PubMed  
    Q13616 P10827 THRA    HPRD  PubMed  
    BioGRID:114032 BioGRID:119674 ASB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:122954 BORA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114032 BioGRID:126147 C20orf94    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114032 BioGRID:120937 CAND1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114032 BioGRID:107067 CCND1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:107428 CDC25A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:107432 CDC34    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114032 BioGRID:123657 CDCA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:107462 CDKN1C    BioGRID  PubMed Biochemical Activity 
    BioGRID:114032 BioGRID:123555 CDT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:107491 CENPE    BioGRID  PubMed Two-hybrid 
    BioGRID:114032 BioGRID:107569 CHUK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:107582 CKS1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114032 BioGRID:107603 CLU    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:127317 COMMD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114032 BioGRID:114729 COPS2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:114103 COPS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114032 BioGRID:119324 COPS4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114032 BioGRID:116176 COPS6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114032 BioGRID:116124 COPS8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:122728 CORO7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:114032 CUL1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114032 BioGRID:119920 DCUN1D1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:114032 BioGRID:108126 DNMT3B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:108201 E2F1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:114032 BioGRID:116298 FAF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114032 BioGRID:116806 FAF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:117615 FBXL3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:117625 FBXL5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:123173 FBXO11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:124333 FBXO18    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114032 BioGRID:122890 FBXO31    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:117656 FBXO4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114032 BioGRID:119962 FBXO42    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:117326 FBXO7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:117653 FBXO8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:116887 FBXW11    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114032 BioGRID:117603 FBXW2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:120581 FBXW7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114032 BioGRID:117645 FBXW8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114032 BioGRID:114093 GCM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:109131 GPS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:118815 HIPK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:109767 IKBKB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:114089 IKBKG    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:120041 ING3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:115156 KEAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:115319 MED6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114032 BioGRID:110859 NFKBIA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:119685 NLK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:121014 NSFL1C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:125385 OSBPL10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114032 BioGRID:111105 PARK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114032 BioGRID:111391 PMS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:111656 PSMA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:111658 PSMA4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:111660 PSMA6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114032 BioGRID:111661 PSMA7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114032 BioGRID:111683 PSMD4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114032 BioGRID:111715 PTGS2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:111818 RAC2    BioGRID  PubMed Two-hybrid 
    BioGRID:114032 BioGRID:116356 RASSF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:111869 RBL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:115301 RBX1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-fractionation; Reconstituted Complex; Two-hybrid 
    BioGRID:114032 BioGRID:128962 RICTOR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114032 BioGRID:114977 RNF7    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:114032 BioGRID:121145 RPRM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114032 BioGRID:207980 Rbx1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114032 BioGRID:202921 Rnf7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:122735 SAP130    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:112344 SGK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:114032 BioGRID:112391 SKP1    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Co-fractionation; Reconstituted Complex; Two-hybrid 
    BioGRID:114032 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-fractionation; Reconstituted Complex 
    BioGRID:114032 BioGRID:122479 SLX1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114032 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:112509 SNRNP70    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:205208 Skp2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:207969 Stub1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:118878 TBK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114032 BioGRID:112923 THRA    BioGRID  PubMed Two-hybrid 
    BioGRID:114032 BioGRID:113014 TP73    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:112615 TRIM21    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:114032 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114032 BioGRID:119239 UBXN1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114032 BioGRID:117507 UBXN7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114032 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114032 BioGRID:119592 ZC3HC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114032 BioGRID:592682 skp2    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the CUL1 gene: The CUL1 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, , and N.crassa.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
      APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
    • Activation of NF-kappaB in B Cells, organism-specific biosystem (from REACTOME)
      Activation of NF-kappaB in B Cells, organism-specific biosystemDAG and calcium activate protein kinase C beta (PKC-beta, Kochs et al. 1991) which phosphorylates CARMA1 and other proteins (Sommer et al. 2005). Phosphorylated CARMA1 recruits BCL10 and MALT1 to for...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Canonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Canonical Wnt signaling pathway, organism-specific biosystem
      Canonical Wnt signaling pathway
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Circadian Clock, organism-specific biosystem (from REACTOME)
      Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 heterodimer transactivates CRY and PER genes by binding E-box element...
    • Circadian rhythm - mammal, organism-specific biosystem (from KEGG)
      Circadian rhythm - mammal, organism-specific biosystem
      Circadian rhythm - mammal
    • Circadian rhythm - mammal, conserved biosystem (from KEGG)
      Circadian rhythm - mammal, conserved biosystem
      Circadian rhythm - mammal
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
      Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemCyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. Af...
    • Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
      Cyclin D associated events in G1, organism-specific biosystemThree D-type cyclins are essential for progression from G1 to S-phase. These D cyclins bind to and activate both CDK4 and CDK6. The formation of all possible complexes between the D-type cyclins and...
    • Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
      Cyclin E associated events during G1/S transition, organism-specific biosystemThe transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes. As the Cyclin E:Cdk2 complexes are formed, the Cdk2 is phosphorylated by the Wee1 and Myt1 kinases. This phosphoryl...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
      Degradation of beta-catenin by the destruction complex, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
    • Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
    • G1 Phase, organism-specific biosystem (from REACTOME)
      G1 Phase, organism-specific biosystemEarly cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6. An important target for these CDKs is the Retinoblastoma (Rb) protein, which when phosphoryl...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
      NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
    • Notch signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Notch signaling pathway, organism-specific biosystem
      Notch signaling pathway
    • Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Nuclear signaling by ERBB4, organism-specific biosystemBesides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A CYT2) undergo proteolytic cleavage by ADAM17 (TACE) in the juxtamembr...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Prolactin receptor signaling, organism-specific biosystem (from REACTOME)
      Prolactin receptor signaling, organism-specific biosystemProlactin (PRL) is a hormone secreted mainly by the anterior pituitary gland. It was originally identified by its ability to stimulate the development of the mammary gland and lactation, but is now k...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
      Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemThe APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zacha...
    • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
      Regulation of mitotic cell cycle, organism-specific biosystem
      Regulation of mitotic cell cycle
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continu...
    • SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystem (from REACTOME)
      SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystemDuring G1, the activity of cyclin-dependent kinases (CDKs) is kept in check by the CDK inhibitors (CKIs) p27 and p21, thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 20...
    • SCF-BTRC complex, organism-specific biosystem (from KEGG)
      SCF-BTRC complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-FBS complex, organism-specific biosystem (from KEGG)
      SCF-FBS complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-FBS complex, conserved biosystem (from KEGG)
      SCF-FBS complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-FBW7 complex, organism-specific biosystem (from KEGG)
      SCF-FBW7 complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-SKP2 complex, organism-specific biosystem (from KEGG)
      SCF-SKP2 complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystem (from REACTOME)
      SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystemEmi1 destruction in early mitosis requires the SCF�²TrCP ubiquitin ligase complex. Binding of �²TrCP to Emi1 occurs in late prophase and requires phosphorylation at the DSGxxS consensus motif as...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
      TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TGF-beta signaling pathway, conserved biosystem (from KEGG)
      TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    G1 phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		  
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle arrest TAS
    Traceable Author Statement
    more info
    		 PubMed 
    induction of apoptosis by intracellular signals TAS
    Traceable Author Statement
    more info
    		 PubMed 
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    cullin-1
    Names
    cullin-1
    CUL-1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003592.2 → NP_003583.2  cullin-1

      Status: VALIDATED

      Source sequence(s)
      AF062536, AK096163, BG391038, CA945052
      Consensus CDS
      CCDS34772.1
      UniProtKB/TrEMBL
      B3KTW0
      UniProtKB/Swiss-Prot
      Q13616
      Related
      ENSP00000326804, ENST00000325222
      Conserved Domains (3) summary
      smart00182
      Location:455 – 590
      Blast Score: 497
      CULLIN; Cullin
      pfam00888
      Location:21 – 636
      Blast Score: 1541
      Cullin; Cullin family
      cl11186
      Location:703 – 770
      Blast Score: 285
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      148395933..148498202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      142474925..142577198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      147733888..147836155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AACC02000041.1 EAL24422.1
    genomic AC005229.2 AAM49153.1
    genomic AC006323.3 AAS02034.1
    genomic CH471146.2 EAW80072.1
      EAW80073.1
      EAW80074.1
    mRNA AF062536.1 AAC36681.1
    mRNA AK096163.1 BAG53222.1
    mRNA AK096505.1 BAG53307.1
    mRNA AK296909.1 BAG59465.1
    mRNA AK315023.1 None
    mRNA BC034318.1 None
    mRNA BC125119.1 AAI25120.1
    mRNA BC125120.1 AAI25121.1
    mRNA BG391038.1 None
    mRNA BX537409.1 CAD97651.1
    mRNA CA945052.1 None
    mRNA U58087.1 AAC50544.1
    other-genetic AM393444.1 CAL38322.1
    other-genetic AM393566.1 CAL38443.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13616.2 GenPept UniProtKB/Swiss-Prot:Q13616
    Q75MQ1 GenPept UniProtKB/TrEMBL:Q75MQ1
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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