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    MCHR2 melanin-concentrating hormone receptor 2 [ Homo sapiens ]

    Gene ID: 84539, updated on 11-May-2012
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    Summary

    Official Symbol
    MCHR2provided by HGNC
    Official Full Name
    melanin-concentrating hormone receptor 2provided by HGNC
    Primary source
    HGNC:20867
    See related
    Ensembl:ENSG00000152034; HPRD:12088; MIM:606111; Vega:OTTHUMG00000015270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLT; MCH2; MCH2R; GPR145; GPRv17; MCH-2R; MCH-R2; MCHR-2
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    Genomic context

    Location :
    6q16
    Sequence :
    Chromosome: 6; NC_000006.11 (100367786..100442114, complement)
    See MCHR2 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S3 pseudogene 5 Neighboring gene PR domain containing 13 Neighboring gene uncharacterized LOC728012 Neighboring gene nucleophosmin (nucleolar phosphoprotein B23, numatrin) pseudogene Neighboring gene tetratricopeptide repeat domain 22 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Elks CE, et al. Nat Genet, 2010 Dec. PMID 21102462.
    2. Establishment of CHO cell line expressing human MCHR2 gene and research of its molecular characteristics. Yuan C, et al. Indian J Exp Biol, 2009 Nov. PMID 20099459.
    3. A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder. Abou Jamra R, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jun 5. PMID 19927306.
    4. Melanin-concentrating hormone receptor 2 affects 3T3-L1 preadipocyte differentiation. Yang J, et al. Mol Cell Endocrinol, 2009 Nov 13. PMID 19683862.
    5. Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder. Miller CL, et al. Schizophr Res, 2009 Sep. PMID 19502010.

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. construction of the CHO cell line and the research of MCHR2 molecular characteristics have established a good experimental basis for the further research about the function of MCHR2 gene
      Title: Establishment of CHO cell line expressing human MCHR2 gene and research of its molecular characteristics.
    2. MCHR2 positively mediates the regulation of melanin-concentrating hormone during preadipocyte differentiation and is involved in energy balance regulation without affecting preadipocyte proliferation.
      Title: Melanin-concentrating hormone receptor 2 affects 3T3-L1 preadipocyte differentiation.
    3. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder.
    5. MCHR2 is not a major contributor to polygenic obesity
      Title: Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity.
    6. results of molecular simulations of MCHR2 in the free and hormone-bound forms provide suggestions on the amino acids responsible for the transfer of the structural changes from the agonist binding site to the G-protein coupling domains
      Title: Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.
    7. MCH1 and MCH2 receptors were investigated and are different from those in SVK14 cells.
      Title: SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor.
    8. The 10-amino-acid cyclic core of the hMCH neuropeptide with the Arg attached to the N-terminus of the disulfide ring is sufficient for full activation of melanin-concentrating hormone receptor 2.
      Title: Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q969V1 P20382 PMCH    HPRD  PubMed  
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    General gene information

    Markers

    Genotypes

    Pathways from BioSystems

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Other, organism-specific biosystem (from WikiPathways)
      GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    melanin-concentrating hormone receptor 2
    Names
    melanin-concentrating hormone receptor 2
    MCH receptor 2
    G protein-coupled receptor 145
    G protein-coupled receptor slt
    G-protein coupled receptor 145
    melanin-concentrating hormone 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040179.1 → NP_001035269.1  melanin-concentrating hormone receptor 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK123634, AL590725
      Consensus CDS
      CCDS5044.1
      UniProtKB/Swiss-Prot
      Q969V1
      Related
      ENSP00000281806, ENST00000281806
      Conserved Domains (2) summary
      pfam00001
      Location:57 – 306
      Blast Score: 282
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl10458
      Location:48 – 147
      Blast Score: 95
      7tm_4; Olfactory receptor

    2. NM_032503.2 → NP_115892.2  melanin-concentrating hormone receptor 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK123634, AL590725
      Consensus CDS
      CCDS5044.1
      UniProtKB/Swiss-Prot
      Q969V1
      Related
      ENSP00000403490, ENST00000445970
      Conserved Domains (2) summary
      pfam00001
      Location:57 – 306
      Blast Score: 282
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl10458
      Location:48 – 147
      Blast Score: 95
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      100367786..100442114, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      97807284..97881990, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL590725.5 CAH70022.1
    genomic CH471051.2 EAW48459.1
      EAW48460.1
    mRNA AB058849.1 BAB87842.1
    mRNA AB060151.1 BAB55677.1
    mRNA AF347063.1 AAK32193.1
    mRNA AF399937.1 AAL05528.1
    mRNA AK123634.1 BAG53926.1
    mRNA AY029596.1 AAK38157.1
    mRNA AY562946.1 AAS72374.1
    mRNA BC038441.1 None
    mRNA BC095515.1 AAH95515.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q969V1.1 GenPept UniProtKB/Swiss-Prot:Q969V1
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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