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ACSS1 acyl-CoA synthetase short-chain family member 1 [ Homo sapiens (human) ]

Gene ID: 84532, updated on 8-May-2016
Official Symbol
ACSS1provided by HGNC
Official Full Name
acyl-CoA synthetase short-chain family member 1provided by HGNC
Primary source
HGNC:HGNC:16091
See related
Ensembl:ENSG00000154930 HPRD:12413; MIM:614355; Vega:OTTHUMG00000032112
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACAS2L; ACECS1; AceCS2L
Summary
This gene encodes a mitochondrial acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Orthologs
Location:
20p11.21
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (25006230..25058182, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (24986866..25038818, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene cystatin F Neighboring gene adipocyte plasma membrane associated protein Neighboring gene visual system homeobox 1 Neighboring gene V-set domain containing T cell activation inhibitor 1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common genetic variation and performance on standardized cognitive tests.
NHGRI GWA Catalog
  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Carbon metabolism, organism-specific biosystem (from KEGG)
    Carbon metabolism, organism-specific biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Carbon metabolism, conserved biosystem (from KEGG)
    Carbon metabolism, conserved biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Ethanol oxidation, organism-specific biosystem (from REACTOME)
    Ethanol oxidation, organism-specific biosystemEthanol and related alcohols can be ingested as part of the diet and are formed by microorganisms in the intestinal tract. Ethanol oxidation to acetate occurs primarily in liver cells in a multistep ...
  • Glycolysis / Gluconeogenesis, organism-specific biosystem (from KEGG)
    Glycolysis / Gluconeogenesis, organism-specific biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
  • Glycolysis / Gluconeogenesis, conserved biosystem (from KEGG)
    Glycolysis / Gluconeogenesis, conserved biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
    Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...
  • Propanoate metabolism, organism-specific biosystem (from KEGG)
    Propanoate metabolism, organism-specific biosystem
    Propanoate metabolism
  • Propanoate metabolism, conserved biosystem (from KEGG)
    Propanoate metabolism, conserved biosystem
    Propanoate metabolism
  • Pyruvate metabolism, organism-specific biosystem (from KEGG)
    Pyruvate metabolism, organism-specific biosystem
    Pyruvate metabolism
  • Pyruvate metabolism, conserved biosystem (from KEGG)
    Pyruvate metabolism, conserved biosystem
    Pyruvate metabolism
  • SREBP signalling, organism-specific biosystem (from WikiPathways)
    SREBP signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
  • Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class III, organism-specific biosystem
    Signaling events mediated by HDAC Class III
  • Statin Pathway, organism-specific biosystem (from WikiPathways)
    Statin Pathway, organism-specific biosystemStatins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ45659, MGC33843

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AMP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
acetate-CoA ligase activity EXP
Inferred from Experiment
more info
PubMed 
acetate-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acetate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acetyl-CoA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acetyl-CoA biosynthetic process from acetate IEA
Inferred from Electronic Annotation
more info
 
ethanol oxidation TAS
Traceable Author Statement
more info
 
propionate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
Preferred Names
acetyl-coenzyme A synthetase 2-like, mitochondrial
Names
acetate--CoA ligase 2
NP_001239604.1
NP_001239605.1
NP_001239606.1
NP_115890.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252675.1NP_001239604.1  acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239604.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK092295, AK125923, AW024920, BC044588, BM150326
    UniProtKB/Swiss-Prot
    Q9NUB1
    Conserved Domains (2) summary
    cd05966
    Location:64665
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
    TIGR02188
    Location:54674
    Ac_CoA_lig_AcsA; acetate--CoA ligase
  2. NM_001252676.1NP_001239605.1  acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK125923, AK296306, AK314440, AW024920, DC404033
    Consensus CDS
    CCDS58764.1
    UniProtKB/Swiss-Prot
    Q9NUB1
    Related
    ENSP00000439304, ENST00000537502
    Conserved Domains (2) summary
    COG0365
    Location:23543
    Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]
    cl17068
    Location:23546
    AFD_class_I; Adenylate forming domain, Class I superfamily
  3. NM_001252677.1NP_001239606.1  acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a translational frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK125923, AK127566, AW024920, BC114612, BM150326
    Consensus CDS
    CCDS58765.1
    UniProtKB/Swiss-Prot
    Q9NUB1
    UniProtKB/TrEMBL
    Q1RMZ4
    Related
    ENSP00000388793, ENST00000432802
    Conserved Domains (2) summary
    pfam00501
    Location:115555
    AMP-binding; AMP-binding enzyme
    cl17068
    Location:64555
    AFD_class_I; Adenylate forming domain, Class I superfamily
  4. NM_032501.3NP_115890.2  acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_115890.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK125923, AK314440, AW024920, BM150326
    Consensus CDS
    CCDS13167.1
    UniProtKB/Swiss-Prot
    Q9NUB1
    Related
    ENSP00000316924, OTTHUMP00000030470, ENST00000323482, OTTHUMT00000078386
    Conserved Domains (2) summary
    cd05966
    Location:64667
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
    TIGR02188
    Location:54676
    Ac_CoA_lig_AcsA; acetate--CoA ligase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

    Range
    25006230..25058182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723659.1XP_006723722.1  

    Conserved Domains (2) summary
    cl17068
    Location:64462
    AFD_class_I; Adenylate forming domain, Class I superfamily
    TIGR02188
    Location:54471
    Ac_CoA_lig_AcsA; acetate--CoA ligase
  2. XM_011529388.1XP_011527690.1  

    Conserved Domains (1) summary
    cl17068
    Location:52449
    AFD_class_I; Adenylate forming domain, Class I superfamily

RNA

  1. XR_937170.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    24987355..25039309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)