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    CUL2 cullin 2 [ Homo sapiens ]

    Gene ID: 8453, updated on 12-May-2012
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    Summary

    Official Symbol
    CUL2provided by HGNC
    Official Full Name
    cullin 2provided by HGNC
    Primary source
    HGNC:2552
    Locus tag
    RP11-297A16.3
    See related
    Ensembl:ENSG00000108094; HPRD:06786; MIM:603135; Vega:OTTHUMG00000017950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGC131970
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    Genomic context

    Location :
    10p11.21
    Sequence :
    Chromosome: 10; NC_000010.10 (35297479..35379570, complement)
    See CUL2 in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene synovial sarcoma translocation gene on chromosome 18-like 2 pseudogene Neighboring gene peroxiredoxin 2 pseudogene Neighboring gene microRNA 3611 Neighboring gene RNA, U7 small nuclear 77 pseudogene Neighboring gene cAMP responsive element modulator Neighboring gene ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 pseudogene 4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Proteomic dissection of the von Hippel-Lindau (VHL) interactome. Lai Y, et al. J Proteome Res, 2011 Nov 4. PMID 21942715.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters. Costessi A, et al. EMBO J, 2011 Aug 5. PMID 21822215.

    See all (79) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The authors applied protein-complex purification strategies and identified PRAME as a substrate recognition subunit of a Cullin2-based E3 ubiquitin ligase.
      Title: The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters.
    2. The data suggest that neither HIF1alpha nor CUL2 mutation may play a central role in HIF1alpha activation in gastric, colorectal, breast, lung and hepatocellular carcinomas, and acute leukemias.
      Title: Mutational analysis of hypoxia-related genes HIF1alpha and CUL2 in common human cancers.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Mutational analysis of hypoxia-related genes HIF1alpha and CUL2 in common human cancers.
    4. CUL2 is required for normal vasculogenesis, at least in part mediated by its regulation of HIF-mediated transcription.
      Title: CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis.
    5. the HPV16 E7-associated cullin 2 ubiquitin ligase complex contributes to aberrant degradation of the pRB tumor suppressor in HPV16 E7-expressing cells.
      Title: Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor.
    6. Cullin selection is determined by specific Elongin C and Skp1 sequences
      Title: Identification of Elongin C and Skp1 sequences that determine Cullin selection.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q13617 Q86VP6 CAND1    HPRD  PubMed  
    Q13617 Q8N668 COMMD1    HPRD  PubMed  
    Q13617 Q13098 GPS1    HPRD  PubMed  
    Q13617 Q15843 NEDD8    HPRD  PubMed  
    Q13617 Q9UBF6 RNF7    HPRD  PubMed  
    Q13617 Q15369 TCEB1    HPRD  PubMed  
    Q13617 P40337 VHL    HPRD  PubMed  
    Q13617 Q7Z7L7 ZER1    HPRD  PubMed  
    Q13617 Q9C0D3 ZYG11B    HPRD  PubMed  
    BioGRID:114031 BioGRID:106663 ADRB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114031 BioGRID:113894 ARID1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114031 BioGRID:121559 ARID1B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114031 BioGRID:106898 ARNT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114031 BioGRID:119674 ASB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114031 BioGRID:119669 ASB4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114031 BioGRID:119696 CAB39    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:120937 CAND1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114031 BioGRID:126387 CMBL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:127317 COMMD1    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:114031 BioGRID:114729 COPS2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114031 BioGRID:114103 COPS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:116176 COPS6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:119920 DCUN1D1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114031 BioGRID:108085 DLG3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:108126 DNMT3B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114031 BioGRID:116298 FAF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114031 BioGRID:116806 FAF2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114031 BioGRID:117645 FBXW8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:109338 HIF1A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114031 BioGRID:108918 KAT2A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114031 BioGRID:119958 KCTD5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:115156 KEAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114031 BioGRID:116652 KLHDC10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:125219 MED8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114031 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114031 BioGRID:121014 NSFL1C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114031 BioGRID:111073 P4HB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:111230 PFKFB3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:115301 RBX1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:114031 BioGRID:111902 RELA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114031 BioGRID:114977 RNF7    BioGRID  PubMed Two-hybrid 
    BioGRID:114031 BioGRID:120477 RNMTL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:137297 RPL35P5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:207980 Rbx1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114031 BioGRID:202921 Rnf7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114031 BioGRID:122735 SAP130    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114031 BioGRID:119289 SH3GLB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:108354 STOM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:198719 Socs1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114031 BioGRID:114745 TCEAL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:112783 TCEB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114031 BioGRID:112785 TCEB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114031 BioGRID:112888 TFE3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:117722 TIMM13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114031 BioGRID:113169 UBE2D1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114031 BioGRID:119239 UBXN1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114031 BioGRID:117507 UBXN7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114031 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114031 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114031 BioGRID:219684 Wsb1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114031 BioGRID:1205537 gag    BioGRID  PubMed Co-purification 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • ECV complex, organism-specific biosystem (from KEGG)
      ECV complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem (from Pathway Interaction Database)
      Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem
      Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
      Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell cycle arrest TAS
    Traceable Author Statement
    more info
    		 PubMed 
    induction of apoptosis by intracellular signals TAS
    Traceable Author Statement
    more info
    		 PubMed 
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cullin-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    cullin-2
    Names
    cullin-2
    CUL-2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198777.1 → NP_001185706.1  cullin-2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AI089201, AK095217, AL392046, BC009591
      Consensus CDS
      CCDS7179.1
      UniProtKB/Swiss-Prot
      Q13617
      Related
      ENSP00000363883, OTTHUMP00000019436, ENST00000374751, OTTHUMT00000047537
      Conserved Domains (3) summary
      smart00182
      Location:424 – 568
      Blast Score: 512
      CULLIN; Cullin
      pfam00888
      Location:14 – 645
      Blast Score: 1536
      Cullin; Cullin family
      cl11186
      Location:672 – 739
      Blast Score: 277
      Cullin_Nedd8; Cullin protein neddylation domain

    2. NM_001198778.1 → NP_001185707.1  cullin-2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AI089201, AL392046, BC009591, DC401811
      Consensus CDS
      CCDS55709.1
      UniProtKB/TrEMBL
      G3V1S2
      UniProtKB/Swiss-Prot
      Q13617
      Related
      ENSP00000444856, ENST00000537177
      Conserved Domains (3) summary
      smart00182
      Location:443 – 587
      Blast Score: 512
      CULLIN; Cullin
      pfam00888
      Location:33 – 664
      Blast Score: 1541
      Cullin; Cullin family
      cl11186
      Location:691 – 758
      Blast Score: 279
      Cullin_Nedd8; Cullin protein neddylation domain

    3. NM_001198779.1 → NP_001185708.1  cullin-2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AI089201, AK310225, AL392046, BC009591, DC401811
      UniProtKB/Swiss-Prot
      Q13617
      Conserved Domains (3) summary
      smart00182
      Location:437 – 581
      Blast Score: 512
      CULLIN; Cullin
      pfam00888
      Location:27 – 658
      Blast Score: 1540
      Cullin; Cullin family
      cl11186
      Location:685 – 752
      Blast Score: 278
      Cullin_Nedd8; Cullin protein neddylation domain

    4. NM_003591.3 → NP_003582.2  cullin-2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AI089201, AL392046, BC009591, DC401936
      Consensus CDS
      CCDS7179.1
      UniProtKB/Swiss-Prot
      Q13617
      Related
      ENSP00000363881, OTTHUMP00000019440, ENST00000374749, OTTHUMT00000047542
      Conserved Domains (3) summary
      smart00182
      Location:424 – 568
      Blast Score: 512
      CULLIN; Cullin
      pfam00888
      Location:14 – 645
      Blast Score: 1536
      Cullin; Cullin family
      cl11186
      Location:672 – 739
      Blast Score: 277
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      35297479..35379570, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      35016158..35098233, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL392046.11 CAI13162.1
      CAI13163.1
      CAI13164.1
      CAI13165.1
    genomic CH471072.2 EAW85924.1
      EAW85925.1
      EAW85926.1
      EAW85927.1
      EAW85928.1
    mRNA AF126404.1 AAD23581.1
    mRNA AI089201.1 None
    mRNA AK095217.1 BAG53007.1
    mRNA AK294080.1 BAH11667.1
    mRNA AK300491.1 BAH13294.1
    mRNA AK310225.1 None
    mRNA AL832733.1 None
    mRNA BC009591.1 AAH09591.1
    mRNA BC095405.1 None
    mRNA BC110901.1 AAI10902.1
    mRNA DC401811.1 None
    mRNA DC401936.1 None
    mRNA U58088.1 AAC50545.1
    mRNA U83410.1 AAC51190.1
    other-genetic JF432297.1 ADZ15514.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13617.2 GenPept UniProtKB/Swiss-Prot:Q13617
    Q5T2B4 GenPept UniProtKB/TrEMBL:Q5T2B4
    Q5T2B5 GenPept UniProtKB/TrEMBL:Q5T2B5
    Q5T2B7 GenPept UniProtKB/TrEMBL:Q5T2B7
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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