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    CUL3 cullin 3 [ Homo sapiens ]

    Gene ID: 8452, updated on 11-May-2012

    Summary

    Official Symbol
    CUL3provided by HGNC
    Official Full Name
    cullin 3provided by HGNC
    Primary source
    HGNC:2553
    See related
    Ensembl:ENSG00000036257; HPRD:09123; MIM:603136; Vega:OTTHUMG00000133167
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CUL-3; PHA2E; FLJ25665
    Summary
    This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

    Genomic context

    Location :
    2q36.2
    Sequence :
    Chromosome: 2; NC_000002.11 (225334869..225450110, complement)
    See CUL3 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene Neighboring gene family with sequence similarity 124B Neighboring gene ankyrin repeat domain 49 pseudogene Neighboring gene dedicator of cytokinesis 10 Neighboring gene microRNA 4439 Neighboring gene neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q13618 Q86VP6 CAND1    HPRD  PubMed  
    Q13618 P24385 CCND1    HPRD  PubMed  
    Q13618 P24864 CCNE1    HPRD  PubMed  
    Q13618 Q13098 GPS1    HPRD  PubMed  
    Q13618 Q15843 NEDD8    HPRD  PubMed  
    Q13618 P62877 RBX1    HPRD  PubMed  
    Q13618 P61956 SUMO2    HPRD  PubMed  
    Q13618 P55854 SUMO3    HPRD  PubMed  
    BioGRID:114030 BioGRID:117367 ABTB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114030 BioGRID:106890 ARHGDIB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:116945 ARHGEF12    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:114030 BioGRID:107068 BCL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:107116 BMI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:120937 CAND1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114030 BioGRID:107338 CCNE1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:114030 BioGRID:127317 COMMD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114030 BioGRID:114103 COPS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114030 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114030 BioGRID:116176 COPS6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114030 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-Western; FRET 
    BioGRID:114030 BioGRID:205013 Cul3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114030 BioGRID:107982 DAPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:119920 DCUN1D1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114030 BioGRID:108126 DNMT3B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:108127 DNTT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:114079 ENC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:116298 FAF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114030 BioGRID:116806 FAF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:117223 GABARAPL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114030 BioGRID:116473 GABARAPL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114030 BioGRID:113800 GAN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:114927 H2AFY    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:109531 HSF2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:114030 BioGRID:109767 IKBKB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:116285 KATNA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:115607 KBTBD10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:123873 KBTBD7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114030 BioGRID:127031 KCTD11    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:114030 BioGRID:119958 KCTD5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114030 BioGRID:115156 KEAP1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:114030 BioGRID:121601 KLHDC5    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:114030 BioGRID:121890 KLHL12    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:124688 KLHL13    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:118100 KLHL20    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:115232 KLHL21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:121009 KLHL9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:218522 Klhl2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:113841 NCOA3    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:114030 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114030 BioGRID:110852 NFE2L2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:114030 BioGRID:121014 NSFL1C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:122240 PDIA2    BioGRID  PubMed Two-hybrid 
    BioGRID:114030 BioGRID:128154 PGAM5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:111391 PMS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:115301 RBX1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114030 BioGRID:106880 RHOA    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:114030 BioGRID:207980 Rbx1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114030 BioGRID:202921 Rnf7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:113993 SPOP    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:114030 BioGRID:114397 SQSTM1    BioGRID  PubMed Co-localization 
    BioGRID:114030 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114030 BioGRID:112496 SUMO3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114030 BioGRID:249109 Tceb1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:249665 Tceb2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114030 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114030 BioGRID:119239 UBXN1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114030 BioGRID:117507 UBXN7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114030 BioGRID:283159 btbd6a    BioGRID  PubMed Affinity Capture-Western 

    General gene information

    Markers

    Homology

    • Homologs of the CUL3 gene: The CUL3 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cyclin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    Wnt receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    anaphase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle arrest TAS
    Traceable Author Statement
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gastrulation IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    induction of apoptosis by intracellular signals TAS
    Traceable Author Statement
    more info
    PubMed 
    mitotic anaphase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trophectodermal cellular morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    polar microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cullin-3
    Names
    cullin-3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032169.1 RefSeqGene

      Range
      5001..120248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001257197.1NP_001244126.1  cullin-3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, comapred to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB014517, AC073052, AK299644, BQ688156
      UniProtKB/Swiss-Prot
      Q13618
      Conserved Domains (3) summary
      smart00182
      Location:355497
      Blast Score: 563
      CULLIN; Cullin
      pfam00888
      Location:23600
      Blast Score: 1494
      Cullin; Cullin family
      cl11186
      Location:629695
      Blast Score: 281
      Cullin_Nedd8; Cullin protein neddylation domain
    2. NM_001257198.1NP_001244127.1  cullin-3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB014517, AC073052, AK308496
      Conserved Domains (3) summary
      smart00182
      Location:427569
      Blast Score: 561
      CULLIN; Cullin
      pfam00888
      Location:40672
      Blast Score: 1626
      Cullin; Cullin family
      cl11186
      Location:701767
      Blast Score: 282
      Cullin_Nedd8; Cullin protein neddylation domain
    3. NM_003590.4NP_003581.1  cullin-3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AB014517, AC073052, BQ688156
      Consensus CDS
      CCDS2462.1
      UniProtKB/Swiss-Prot
      Q13618
      Related
      ENSP00000264414, OTTHUMP00000164219, ENST00000264414, OTTHUMT00000256871
      Conserved Domains (3) summary
      smart00182
      Location:421563
      Blast Score: 561
      CULLIN; Cullin
      pfam00888
      Location:34666
      Blast Score: 1630
      Cullin; Cullin family
      cl11186
      Location:695761
      Blast Score: 281
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      225334869..225450110, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      217186562..217300381, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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