KIAA1804 mixed lineage kinase 4 [Homo sapiens] - Gene

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Summary

Gene symbol: KIAA1804
Gene description: mixed lineage kinase 4
See related: Ensembl:ENSG00000143674; HPRD:10087; Vega:OTTHUMG00000037889
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MLK4; dJ862P8.3; RP5-862P8.2

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Genomic context

Location :: 1q42

Sequence :: Chromosome: 1; NC_000001.10 (233463514..233520894)

See KIAA1804 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MLK4 is a negative regulator of TLR4 signaling.
Title: MLK4 has negative effect on TLR4 signaling.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide meta-analysis for severe diabetic retinopathy.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:124089	BioGRID:110440	MAP3K10		BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
MAP kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
activation of JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info
protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info

General protein information

Preferred Names: mitogen-activated protein kinase kinase kinase MLK4

Names: mitogen-activated protein kinase kinase kinase MLK4

NP_115811.2

EC 2.7.11.25

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032435.2 → NP_115811.2 mitogen-activated protein kinase kinase kinase MLK4

Status: VALIDATED

Source sequence(s)

AJ311798, AL133380

Consensus CDS

CCDS1598.1

UniProtKB/Swiss-Prot

Q5TCX8

Related

ENSP00000355583, OTTHUMP00000036006, ENST00000366624, OTTHUMT00000092495

Conserved Domains (3) summary

cd00174
Location:46 – 97
Blast Score: 166

SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

smart00219
Location:124 – 398
Blast Score: 626

TyrKc; Tyrosine kinase, catalytic domain

cl09925
Location:128 – 399
Blast Score: 521

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

233463514..233520894

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

203953253..204010630

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL133380.5	CAI23045.1
		CAI23046.1
		CAI23047.1
genomic	CH471098.1	EAW69987.1
		EAW69988.1
mRNA	AB058707.1	BAB47433.1
mRNA	AJ311797.1	CAC84639.1
mRNA	AJ311798.1	CAC84640.1
mRNA	BC136648.1	AAI36649.1
mRNA	BC136649.1	AAI36650.1