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    DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [ Homo sapiens ]

    Gene ID: 8445, updated on 11-May-2012
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    Summary

    Official Symbol
    DYRK2provided by HGNC
    Official Full Name
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2provided by HGNC
    Primary source
    HGNC:3093
    See related
    Ensembl:ENSG00000127334; HPRD:04606; MIM:603496; Vega:OTTHUMG00000169089
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLJ21217; FLJ21365
    Summary
    DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    12q15
    Sequence :
    Chromosome: 12; NC_000012.11 (68042512..68056444)
    See DYRK2 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene N-terminal asparagine amidase pseudogene Neighboring gene uncharacterized LOC100507175 Neighboring gene ribosomal protein L39 pseudogene 28 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. Taira N, et al. J Clin Invest, 2012 Mar 1. PMID 22307329.
    2. ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. Taira N, et al. J Biol Chem, 2010 Feb 12. PMID 19965871.
    3. Expression of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 2 (DYRK2) can be a favorable prognostic marker in pulmonary adenocarcinoma. Yamashita S, et al. J Thorac Cardiovasc Surg, 2009 Dec. PMID 19818968.
    4. DYRK2 expression may be a predictive marker for chemotherapy in non-small cell lung cancer. Yamashita S, et al. Anticancer Res, 2009 Jul. PMID 19596956.
    5. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Maddika S, et al. Nat Cell Biol, 2009 Apr. PMID 19287380.

    See all (17) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. DYRK2 regulates tumor progression through modulation of c-Jun and c-Myc
      Title: DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.
    2. The findings indicate that ATM controls stability and pro-apoptotic function of DYRK2 in response to DNA damage.
      Title: ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.
    3. The data showed that DYRK2 expression is associated with a favorable prognosis in pulmonary adenocarcinoma.
      Title: Expression of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 2 (DYRK2) can be a favorable prognostic marker in pulmonary adenocarcinoma.
    4. disease control rate of the DYRK2-positive non-small cell lung cancer patients was significantly different from the DYRK2-negative group
      Title: DYRK2 expression may be a predictive marker for chemotherapy in non-small cell lung cancer.
    5. A protein kinase, DYRK2, has unexpected role as a scaffold for an E3 ubiquitin ligase complex.
      Title: Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.
    6. These findings indicate that DYRK2 regulates p53 to induce apoptosis in response to DNA damage.
      Title: DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q92630 Q16778 HIST2H2BE    HPRD  PubMed  
    Q92630 Q16695 HIST3H3    HPRD  PubMed  
    Q92630 Q9Y620 RAD54B    HPRD  PubMed  
    BioGRID:114023 BioGRID:106962 ATM    BioGRID  PubMed Biochemical Activity 
    BioGRID:114023 BioGRID:113587 DAP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:115532 DCAF7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114023 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114023 BioGRID:108087 DLST    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:127646 EEF1A1P5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:109433 HNRNPU    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:109535 HSPA1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:109536 HSPA1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:109541 HSPA5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:109542 HSPA6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:116285 KATNA1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:114023 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:114023 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:111141 PCMT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:111188 PDHB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:117321 RAD54B    BioGRID  PubMed Two-hybrid 
    BioGRID:114023 BioGRID:118112 RBMXL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:112037 RPA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:112061 RPL18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:112044 RPL4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:112049 RPL7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:112050 RPL7A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:112094 RPLP0    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:112101 RPS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:111269 SLC25A3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:117164 SSBP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:124259 TUBA1C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:113129 TUBA3C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114023 BioGRID:119501 UBR5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114023 BioGRID:115079 VPRBP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114023 BioGRID:127902 WDR69    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114023 BioGRID:121997 XPNPEP3    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the DYRK2 gene: The DYRK2 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, , and N.crassa.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of glycogen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to DNA damage stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 2
    Names
    dual specificity tyrosine-phosphorylation-regulated kinase 2
    NP_003574.1
    NP_006473.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003583.3 → NP_003574.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) does not include the 149 bp insert in the 5' end of the transcript and thus results in a shorter amino-terminal protein.
      Source sequence(s)
      AC078777, AK025018, BC005809, BC006375, CN303286, DA768075, DB461362
      Consensus CDS
      CCDS8979.1
      UniProtKB/Swiss-Prot
      Q92630
      Related
      ENSP00000377186, OTTHUMP00000240071, ENST00000393555, OTTHUMT00000402219
      Conserved Domains (2) summary
      smart00220
      Location:149 – 462
      Blast Score: 672
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09925
      Location:149 – 462
      Blast Score: 546
      PKc_like; Protein Kinases, catalytic domain

    2. NM_006482.2 → NP_006473.2  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes the 149 bp insert in the 5' end of the transcript and thus results in a longer amino-terminal protein.
      Source sequence(s)
      AC078777, AK025018, BC005809, BC006375, CN303286, DA768075, DB461362
      Consensus CDS
      CCDS8978.1
      UniProtKB/Swiss-Prot
      Q92630
      Related
      ENSP00000342105, OTTHUMP00000240070, ENST00000344096, OTTHUMT00000402218
      Conserved Domains (2) summary
      smart00220
      Location:222 – 535
      Blast Score: 682
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09925
      Location:222 – 535
      Blast Score: 554
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      68042512..68056444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      65093416..65107347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC078777.15 (18368..32059) None
    genomic CH471054.1 EAW97176.1
      EAW97177.1
    mRNA AK024870.1 None
    mRNA AK025018.1 None
    mRNA AK313937.1 BAG36656.1
    mRNA BC005809.2 AAH05809.1
    mRNA BC006375.2 AAH06375.1
    mRNA CN303286.1 None
    mRNA DA768075.1 None
    mRNA DB461362.1 None
    mRNA Y09216.1 CAA70418.1
    mRNA Y13493.1 CAA73885.1
    other-genetic JF432719.1 ADZ15936.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92630.3 GenPept UniProtKB/Swiss-Prot:Q92630
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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