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    ABLIM2 actin binding LIM protein family, member 2 [ Homo sapiens (human) ]

    Gene ID: 84448, updated on 5-May-2013
    Official Symbol
    ABLIM2provided by HGNC
    Official Full Name
    actin binding LIM protein family, member 2provided by HGNC
    Primary source
    HGNC:19195
    See related
    Ensembl:ENSG00000163995; MIM:612544; Vega:OTTHUMG00000057427
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Location :
    4p16.1
    Sequence :
    Chromosome: 4; NC_000004.11 (7967037..8160559, complement)
    See ABLIM2 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene sortilin-related VPS10 domain containing receptor 2 Neighboring gene microRNA 4274 Neighboring gene AFAP1 antisense RNA 1 Neighboring gene actin filament associated protein 1 Neighboring gene microRNA 95 Neighboring gene guanine monphosphate synthetase pseudogene 1 Neighboring gene SH3 domain and tetratricopeptide repeats 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779.
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    3. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
    4. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. Barrientos T, et al. J Biol Chem, 2007 Mar 16. PMID 17194709.
    5. Genomic organisation and tissue specific expression of ABLIM2 gene in human, mouse and rat. Klimov E, et al. Biochim Biophys Acta, 2005 Jul 25. PMID 16005990.

    See all (12) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:124086 BioGRID:126483 ABRA    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:124086 BioGRID:106573 ACTA1    BioGRID  PubMed Co-purification 
    BioGRID:124086 BioGRID:112599 SREBF2    BioGRID  PubMed Two-hybrid 
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • DCC mediated attractive signaling, organism-specific biosystem (from REACTOME)
      DCC mediated attractive signaling, organism-specific biosystemThe DCC family includes DCC and neogenin in vertebrates. DCC is required for netrin-induced axon attraction. DCC is a transmembrane protein lacking any identifiable catalytic activity. Protein tyrosi...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
      Netrin-1 signaling, organism-specific biosystemNetrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse a...

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ26534, FLJ39684, KIAA1808, MGC141918, DKFZp761F129

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    axon guidance TAS
    Traceable Author Statement
    more info
    		  
    cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    		  
    intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    actin-binding LIM protein 2
    Names
    actin-binding LIM protein 2
    abLIM-2
    actin binding LIM protein 2
    actin-binding LIM protein family member 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130083.1 → NP_001123555.1  actin-binding LIM protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AJ748601, AK094798, AK097003, BC067214, BE155865, BQ267829
      Consensus CDS
      CCDS47014.1
      UniProtKB/TrEMBL
      E9PF39
      UniProtKB/Swiss-Prot
      Q6H8Q1
      Conserved Domains (5) summary
      cd09327
      Location:24 – 75
      Blast Score: 266
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins.
      cd09328
      Location:80 – 135
      Blast Score: 296
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins.
      cd09329
      Location:153 – 204
      Blast Score: 269
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 – 267
      Blast Score: 314
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:610 – 645
      Blast Score: 179
      VHP; Villin headpiece domain

    2. NM_001130084.1 → NP_001123556.1  actin-binding LIM protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the mid-coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AJ748601, AK097003, BC067214, BQ267829
      Consensus CDS
      CCDS47013.1
      UniProtKB/Swiss-Prot
      Q6H8Q1
      Conserved Domains (5) summary
      cd09327
      Location:24 – 75
      Blast Score: 265
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins.
      cd09328
      Location:80 – 135
      Blast Score: 296
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins.
      cd09329
      Location:153 – 204
      Blast Score: 268
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 – 267
      Blast Score: 313
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:576 – 611
      Blast Score: 178
      VHP; Villin headpiece domain

    3. NM_001130085.1 → NP_001123557.1  actin-binding LIM protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the mid-coding region, and lacks a segment in the 3' coding region, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AJ748600, AK097003, BC067214, BQ267829
      Consensus CDS
      CCDS47012.1
      UniProtKB/Swiss-Prot
      Q6H8Q1
      Related
      ENSP00000441255, ENST00000545242
      Conserved Domains (5) summary
      cd09327
      Location:24 – 75
      Blast Score: 263
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins.
      cd09328
      Location:80 – 135
      Blast Score: 293
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins.
      cd09329
      Location:153 – 204
      Blast Score: 267
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 – 267
      Blast Score: 312
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:537 – 572
      Blast Score: 178
      VHP; Villin headpiece domain

    4. NM_001130086.1 → NP_001123558.1  actin-binding LIM protein 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame segment and uses an alternate in-frame splice site in the mid-coding region, compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AJ748601, AK097003, BC067214, BQ267829, DQ413177
      Consensus CDS
      CCDS47011.1
      UniProtKB/Swiss-Prot
      Q6H8Q1
      Conserved Domains (5) summary
      cd09327
      Location:24 – 75
      Blast Score: 261
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins.
      cd09328
      Location:80 – 135
      Blast Score: 293
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins.
      cd09329
      Location:153 – 204
      Blast Score: 264
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 – 267
      Blast Score: 310
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:524 – 559
      Blast Score: 177
      VHP; Villin headpiece domain

    5. NM_001130087.1 → NP_001123559.1  actin-binding LIM protein 2 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) includes an alternate in-frame exon and uses an alternate in-frame splice site in the mid-coding region, and lacks alternate in-frame segments in both the mid- and 3' coding regions, compared to variant 1. The resulting isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AK094754, AK094798, AK097003, BC067214, BQ267829
      Consensus CDS
      CCDS47015.1
      UniProtKB/Swiss-Prot
      Q6H8Q1
      Related
      ENSP00000354887, OTTHUMP00000219315, ENST00000361737, OTTHUMT00000363009
      Conserved Domains (5) summary
      cd09327
      Location:24 – 75
      Blast Score: 260
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins.
      cd09328
      Location:80 – 135
      Blast Score: 291
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins.
      cd09329
      Location:153 – 204
      Blast Score: 264
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 – 267
      Blast Score: 310
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:496 – 531
      Blast Score: 177
      VHP; Villin headpiece domain

    6. NM_001130088.1 → NP_001123560.1  actin-binding LIM protein 2 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 3' UTR, includes an alternate in-frame exon and lacks an alternate in-frame segment in the mid-coding region, and lacks several exons in the 3' coding region, compared to variant 1. The resulting isoform (7) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK094798, BC067214, BM718728, BQ005420
      Consensus CDS
      CCDS47016.1
      UniProtKB/Swiss-Prot
      Q6H8Q1
      Related
      ENSP00000389410, OTTHUMP00000217348, ENST00000428004, OTTHUMT00000358861
      Conserved Domains (4) summary
      cd09327
      Location:24 – 75
      Blast Score: 254
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins.
      cd09328
      Location:80 – 135
      Blast Score: 284
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins.
      cd09329
      Location:153 – 204
      Blast Score: 258
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 – 267
      Blast Score: 303
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins

    7. NM_032432.4 → NP_115808.3  actin-binding LIM protein 2 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks alternate in-frame segments in both the mid- and 3' coding regions, compared to variant 1. The resulting isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AK094798, AK097003, BC067214, BC122567, BQ267829
      Consensus CDS
      CCDS54719.1
      UniProtKB/Swiss-Prot
      Q6H8Q1
      Conserved Domains (5) summary
      cd09327
      Location:24 – 75
      Blast Score: 258
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins.
      cd09328
      Location:80 – 135
      Blast Score: 290
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins.
      cd09329
      Location:153 – 204
      Blast Score: 262
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 – 267
      Blast Score: 309
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:486 – 521
      Blast Score: 177
      VHP; Villin headpiece domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p10 Primary Assembly

      Range
      7967037..8160559, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      7888374..8079979, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018915.1 Alternate CHM1_1.0

      Range
      7945520..8138256, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01008684.1 (75750..120814) None
    genomic ABBA01008685.1 None
    genomic ABBA01008686.1 None
    genomic ABBA01008687.1 None
    genomic ABBA01008688.1 None
    genomic AC097381.3 (80506..212098) None
    genomic AC104650.2 AAY40931.1
    genomic AC114807.4 None
    genomic AMYH01013927.1 (91902..217348) None
    genomic AMYH01013928.1 None
    genomic CH471131.2 EAW82357.1
      EAW82358.1
    mRNA AB058711.1 BAB47437.1
    mRNA AJ748600.1 CAG38375.1
    mRNA AJ748601.1 CAG38376.1
    mRNA AK094754.1 BAC04414.1
    mRNA AK094798.1 BAC04427.1
    mRNA AK097003.1 None
    mRNA AK130044.1 BAC85284.1
    mRNA AK301060.1 BAH13400.1
    mRNA AL834195.1 CAD38885.2
    mRNA BC067214.1 AAH67214.1
    mRNA BC122567.1 AAI22568.1
    mRNA BE155865.1 None
    mRNA BM718728.1 None
    mRNA BQ005420.1 None
    mRNA BQ267829.1 None
    mRNA DB499366.2 None
    mRNA DB570494.2 None
    mRNA DQ413176.1 ABD83329.1
    mRNA DQ413177.1 ABD83330.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6H8Q1.2 GenPept UniProtKB/Swiss-Prot:Q6H8Q1

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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