DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Homo sapiens] - Gene

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Summary

Official Symbol: DYRK3provided by HGNC
Official Full Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3provided by HGNC
Primary source: HGNC:3094
Locus tag: RP11-343H5.2
See related: Ensembl:ENSG00000143479; HPRD:04607; MIM:603497; Vega:OTTHUMG00000036339
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RED; REDK; DYRK5; hYAK3-2
Summary: This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 1q32.1

Sequence :: Chromosome: 1; NC_000001.10 (206808881..206822542)

See DYRK3 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the lipid raft-dependent endocytosis process mediates C. neoformans internalization into HBMEC and the CD44 protein of the hosts, cytoskeleton, and intracellular kinase-DYRK3 are involved in this process
Title: Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3).
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
Title: DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia
Title: DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia.
DYRK3, expression is strong in erythroid cells and testis, but is also detected in adult kidney and liver
Title: DYRK gene structure and erythroid-restricted features of DYRK3 gene expression.
DYRK3 has roles in kinase activation, binding to CREB, and hematopoietic progenitor cell survival
Title: DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:114022	BioGRID:116915	NEDD4L		BioGRID	PubMed	Biochemical Activity

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
ATP binding	IEA Inferred from Electronic Annotation more info
magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
erythrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: dual specificity tyrosine-phosphorylation-regulated kinase 3

Names: dual specificity tyrosine-phosphorylation-regulated kinase 3; protein kinase Dyrk3; regulatory erythroid kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5

NP_001004023.1

EC 2.7.12.1

NP_003573.2

EC 2.7.12.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004023.1 → NP_001004023.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an additional segment in the coding region compared to variant 1. The resulting isoform (b), also known as the isoform RED-S, contains a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AU126055, BC015501, Y12735

Consensus CDS

CCDS31000.1

UniProtKB/Swiss-Prot

O43781

Related

ENSP00000356075, OTTHUMP00000034528, ENST00000367108, OTTHUMT00000088459

Conserved Domains (2) summary

smart00220
Location:189 – 425
Blast Score: 631

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl09925
Location:189 – 502
Blast Score: 548

PKc_like; Protein Kinases, catalytic domain
NM_003582.2 → NP_003573.2 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript, but encodes the longer isoform (a), also known as the RED-L isoform.

Source sequence(s)

AU126055, BC015501, Y12735

Consensus CDS

CCDS30999.1

UniProtKB/Swiss-Prot

O43781

Related

ENSP00000356076, OTTHUMP00000034527, ENST00000367109, OTTHUMT00000088458

Conserved Domains (2) summary

smart00220
Location:209 – 445
Blast Score: 635

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl09925
Location:209 – 522
Blast Score: 551

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

206808881..206822542

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

177507198..177520842

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL591846.15	CAI13539.1
		CAI13540.1
		CAI13541.1
genomic	CH471100.2	EAW93533.1
		EAW93534.1
		EAW93535.1
mRNA	AF186773.1	AAG17028.1
mRNA	AF186774.1	AAG17029.1
mRNA	AF327561.1	AAK16443.1
mRNA	AK291189.1	BAF83878.1
mRNA	AK308082.1	None
mRNA	AK313245.1	BAG36056.1
mRNA	AU126055.1	None
mRNA	AY590695.1	AAT06103.1
mRNA	BC015501.1	AAH15501.1
mRNA	BC037269.1	AAH37269.1
mRNA	Y12735.2	CAA73266.2
other-genetic	JF432389.1	ADZ15606.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O43781.3	GenPept	UniProtKB/Swiss-Prot:O43781
Q4G0U0	GenPept	UniProtKB/TrEMBL:Q4G0U0
Q5SY34	GenPept	UniProtKB/TrEMBL:Q5SY34