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    CARD11 caspase recruitment domain family, member 11 [ Homo sapiens ]

    Gene ID: 84433, updated on 11-May-2012
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    Summary

    Official Symbol
    CARD11provided by HGNC
    Official Full Name
    caspase recruitment domain family, member 11provided by HGNC
    Primary source
    HGNC:16393
    See related
    Ensembl:ENSG00000198286; HPRD:06234; MIM:607210; Vega:OTTHUMG00000023023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BIMP3; CARMA1; MGC133069
    Summary
    The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    7p22
    Sequence :
    Chromosome: 7; NC_000007.13 (2945709..3083509, complement)
    See CARD11 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene prefoldin subunit 4 pseudogene Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene guanine nucleotide binding protein (G protein) alpha 12 Neighboring gene uncharacterized LOC100129603 Neighboring gene ribosomal protein L21 pseudogene 72 Neighboring gene sidekick cell adhesion molecule 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma. Ramadas RA, et al. J Immunol, 2011 Dec 15. PMID 22075698.
    2. Evaluation of CARMA1/CARD11 and Bob1 as candidate genes in common variable immunodeficiency. Tampella G, et al. J Investig Allergol Clin Immunol, 2011. PMID 21905497.
    3. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    4. [Correlation between the expressions of CARMA1 gene and MUM1 and its significance in diffuse large B cell lymphoma]. Chen YM, et al. Zhonghua Xue Ye Xue Za Zhi, 2011 Apr. PMID 21569705.
    5. CaMKII targets Bcl10 in T-cell receptor induced activation of NF-κB. Oruganti SR, et al. Mol Immunol, 2011 Jul. PMID 21513986.

    See all (51) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. expression of CARMA1 mRNA is likely associated with the expression of MUM1 and shows male predominance in diffuse large B cell lymphoma.
      Title: [Correlation between the expressions of CARMA1 gene and MUM1 and its significance in diffuse large B cell lymphoma].
    2. A combination of in vitro and in vivo studies demonstrates that the CARMA1 transgene is required for optimal T cell responses to T cell receptor engagement and development of allergic airway inflammation, after activation of T cells in a murine model.
      Title: CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.
    3. genetic polymorphism is associated with common variable immunodeficiency
      Title: Evaluation of CARMA1/CARD11 and Bob1 as candidate genes in common variable immunodeficiency.
    4. A20, ABIN-1/2, and CARD11 mutations have prognostic value in gastrointestinal diffuse large B-cell lymphoma
      Title: A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma.
    5. Very low mutation frequency of exons 5-9 in the CARD11 gene from 186 adult acute leukemia and 31 multiple myeloma samples.
      Title: Very low mutation frequency of exons 5-9 in the CARD11 gene from 186 adult acute leukemia and 31 multiple myeloma samples.
    6. PP2A-mediated dephosphorylation of Carma1 is a critical step to limit T-cell activation and effector cytokine production.
      Title: Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation.
    7. CARM1 is transcriptional coactivators that deposit H3R17me2a and H4R3me2a marks, respectively.
      Title: TDRD3 is an effector molecule for arginine-methylated histone marks.
    8. results establish a mechanism that explains how diffuse large B cell lymphoma-associated mutations in CARD11 can initiate spontaneous, receptor-independent activation of NF-kappaB
      Title: Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain.
    9. The mutations of the oncogene CARD11 may contribute to NF-kappaB activation and thereby play a role in the pathogenesis of Primary CNS lymphoma.
      Title: Mutations of CARD11 but not TNFAIP3 may activate the NF-kappaB pathway in primary CNS lymphoma.
    10. the ADAP CARMA1 binding site is required for IKK gamma ubiquitination; both TAK1 and CARMA1 binding sites are required for IkappaB alpha phosphorylation and degradation and NF-kappaB nuclear translocation
      Title: NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein.
    Submit: New GeneRIF Correction See all (27)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_115791.2 NP_003912.1 BCL10    BIND  PubMed CARD11 interacts with BCL10. 
    NP_115791.2 NP_002604.1 PDPK1    BIND  PubMed PDK1 interacts with CARD11. 
    NP_115791.2 NP_006248.1 PRKCQ    BIND  PubMed PRKCQ (PKC-theta) interacts with CARD11 (CARMA1). 
    Q9BXL7 O95999 BCL10    HPRD  PubMed  
    Q9BXL7 Q9Y6K9 IKBKG    HPRD  PubMed  
    Q9BXL7 O43318 MAP3K7    HPRD  PubMed  
    Q9BXL7 O15530 PDPK1    HPRD  PubMed  
    Q9BXL7 P05771 PRKCB    HPRD  PubMed  
    Q9BXL7 Q04759 PRKCQ    HPRD  PubMed  
    Q9BXL7 Q8N5H7 SH2D3C    HPRD  PubMed  
    Q9BXL7 O75083 WDR1    HPRD  PubMed  
    Q9BXL7 P43403 ZAP70    HPRD  PubMed  
    BioGRID:124073 BioGRID:114429 BCL10    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:124073 BioGRID:107316 CBLB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:124073 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:124073 BioGRID:108809 FYB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:124073 BioGRID:109131 GPS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:124073 BioGRID:112748 MAP3K7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:124073 BioGRID:111196 PDPK1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:124073 BioGRID:111574 PRKCQ    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:124073 BioGRID:115717 TAB1    BioGRID  PubMed Two-hybrid 
    BioGRID:124073 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of NF-kappaB in B Cells, organism-specific biosystem (from REACTOME)
      Activation of NF-kappaB in B Cells, organism-specific biosystemDAG and calcium activate protein kinase C beta (PKC-beta, Kochs et al. 1991) which phosphorylates CARMA1 and other proteins (Sommer et al. 2005). Phosphorylated CARMA1 recruits BCL10 and MALT1 to for...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      BCR signaling pathway, organism-specific biosystem
      BCR signaling pathway
    • Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
    • Downstream TCR signaling, organism-specific biosystem (from REACTOME)
      Downstream TCR signaling, organism-specific biosystemChanges in gene expression are required for the T cell to gain full proliferative competence and to produce effector cytokines. Three transcription factors in particular have been found to play a key...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • TCR signaling, organism-specific biosystem (from REACTOME)
      TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD8+ T cells, organism-specific biosystem
      TCR signaling in naive CD8+ T cells

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    CARD domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    guanylate kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    T cell costimulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of I-kappaB kinase/NF-kappaB cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of interleukin-2 biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    thymic T cell selection IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with T cell receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    caspase recruitment domain-containing protein 11
    Names
    caspase recruitment domain-containing protein 11
    carma 1
    card-maguk protein 1
    CARD-containing MAGUK protein 1
    bcl10-interacting maguk protein 3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027759.1 RefSeqGene

      Range
      5001..142801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_032415.4 → NP_115791.3  caspase recruitment domain-containing protein 11

      Status: REVIEWED

      Source sequence(s)
      AA594170, AK074049, AW139089
      Consensus CDS
      CCDS5336.2
      UniProtKB/TrEMBL
      Q8TES3
      UniProtKB/Swiss-Prot
      Q9BXL7
      Related
      ENSP00000380150, OTTHUMP00000024641, ENST00000396946, OTTHUMT00000059344
      Conserved Domains (5) summary
      cd00992
      Location:680 – 752
      Blast Score: 126
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      COG1196
      Location:151 – 460
      Blast Score: 165
      Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]
      cd08808
      Location:22 – 107
      Blast Score: 435
      CARD_CARD11_CARMA1; Caspase activation and recruitment domain of CARD11-like proteins
      cl00357
      Location:168 – 295
      Blast Score: 94
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
      cl09099
      Location:1009 – 1143
      Blast Score: 91
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      2945709..3083509, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      2863784..3002087, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      2993579..3131390, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC004906.3 AAQ96893.1
    genomic AC024028.10 None
    genomic AC092689.2 (1999..27845) None
    genomic CH236953.1 EAL23962.1
    genomic CH471144.1 EAW87276.1
      EAW87277.1
      EAW87278.1
      EAW87279.1
    mRNA AA194010.1 None
    mRNA AA594170.1 None
    mRNA AF322641.1 AAG53402.1
    mRNA AF352576.1 AAL34460.1
    mRNA AK074049.1 BAB84875.1
    mRNA AK097139.1 None
    mRNA AW139089.1 None
    mRNA BC111719.1 AAI11720.2
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BXL7.3 GenPept UniProtKB/Swiss-Prot:Q9BXL7
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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