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Dcx doublecortin [ Rattus norvegicus (Norway rat) ]

Gene ID: 84394, updated on 26-May-2016
Official Symbol
Dcxprovided by RGD
Official Full Name
doublecortinprovided by RGD
Primary source
RGD:620670
See related
Ensembl:ENSRNOG00000047712
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. Studies in knockout mice lacking this gene suggest that this gene has a cortical role in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. This gene is essential for neuronal migration, differentiation, and plasticity, is required for hippocampal development and also plays a role in dendrites development.[provided by RefSeq, Sep 2010]
Orthologs
Location:
Xq14
Exon count:
9
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (115098675..115175517, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (113551874..113628283, complement)

Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene p21 (RAC1) activated kinase 3 Neighboring gene calpain 6 Neighboring gene similar to cell division cycle 2-like 1 Neighboring gene similar to 40S ribosomal protein S19

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding ISO
Inferred from Sequence Orthology
more info
 
microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
axon extension IEA
Inferred from Electronic Annotation
more info
 
axon extension ISO
Inferred from Sequence Orthology
more info
 
brain development ISO
Inferred from Sequence Orthology
more info
 
central nervous system projection neuron axonogenesis IEA
Inferred from Electronic Annotation
more info
 
central nervous system projection neuron axonogenesis ISO
Inferred from Sequence Orthology
more info
 
dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
hippocampus development ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
layer formation in cerebral cortex IEA
Inferred from Electronic Annotation
more info
 
layer formation in cerebral cortex ISO
Inferred from Sequence Orthology
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
pyramidal neuron development IEA
Inferred from Electronic Annotation
more info
 
pyramidal neuron development ISO
Inferred from Sequence Orthology
more info
 
response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
neuronal migration protein doublecortin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053379.3NP_445831.3  neuronal migration protein doublecortin

    See identical proteins and their annotated locations for NP_445831.3

    Status: REVIEWED

    Source sequence(s)
    AABR07040934, AABR07073541
    UniProtKB/TrEMBL
    G3V997
    Related
    ENSRNOP00000065381, ENSRNOT00000074322
    Conserved Domains (1) summary
    cd01617
    Location:53135
    DCX; Ubiquitin-like domain of DCX

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

    Range
    115098675..115175517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257383.2XP_006257445.1  

    Conserved Domains (1) summary
    cd01617
    Location:53135
    DCX; Ubiquitin-like domain of DCX
  2. XM_006257386.2XP_006257448.1  

    Conserved Domains (1) summary
    cd01617
    Location:53135
    DCX; Ubiquitin-like domain of DCX
  3. XM_006257385.2XP_006257447.1  

    See identical proteins and their annotated locations for XP_006257447.1

    Conserved Domains (1) summary
    cd01617
    Location:53135
    DCX; Ubiquitin-like domain of DCX
  4. XM_006257384.2XP_006257446.1  

    Conserved Domains (1) summary
    cd01617
    Location:53135
    DCX; Ubiquitin-like domain of DCX
  5. XM_006257382.2XP_006257444.1  

    See identical proteins and their annotated locations for XP_006257444.1

    Conserved Domains (1) summary
    cd01617
    Location:53135
    DCX; Ubiquitin-like domain of DCX
  6. XM_008773448.1XP_008771670.1  

    Conserved Domains (1) summary
    cd01617
    Location:116198
    DCX; Ubiquitin-like domain of DCX

Alternate Rn_Celera

Genomic

  1. AC_000089.1 Alternate Rn_Celera

    Range
    106829783..106906206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)