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Ikbkb inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 84351, updated on 26-May-2016
Official Symbol
Ikbkbprovided by RGD
Official Full Name
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaprovided by RGD
Primary source
RGD:621375
See related
Ensembl:ENSRNOG00000019073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
IKK2; AIM-1
Summary
kinase that may be involved in megakaryocyte polyploidization [RGD, Feb 2006]
Orthologs
Location:
16q12.5
Exon count:
22
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74177233..74230809)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (73809854..73863636)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693995 Neighboring gene adaptor-related protein complex 3, mu 2 subunit Neighboring gene plasminogen activator, tissue type Neighboring gene polymerase (DNA) beta Neighboring gene dickkopf WNT signaling pathway inhibitor 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
IkappaB kinase activity IEA
Inferred from Electronic Annotation
more info
 
IkappaB kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
I-kappaB phosphorylation IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
cellular response to tumor necrosis factor ISS
Inferred from Sequence or Structural Similarity
more info
 
cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
establishment of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myosin-light-chain-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myosin-light-chain-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cation channel activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of establishment of endothelial barrier IEA
Inferred from Electronic Annotation
more info
 
regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
regulation of phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
serine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
serine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle contraction IEP
Inferred from Expression Pattern
more info
PubMed 
tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
CD40 receptor complex ISO
Inferred from Sequence Orthology
more info
 
IkappaB kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit beta
Names
I-kappa-B kinase 2
I-kappa-B-kinase beta
IKK-B
IKK-beta
NFKBIKB
inhibitor of kappaB kinase beta
inhibitor of nuclear factor kappa B kinase beta subunit
nuclear factor NF-kappa-B inhibitor kinase beta
NP_445807.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053355.2NP_445807.2  inhibitor of nuclear factor kappa-B kinase subunit beta

    See identical proteins and their annotated locations for NP_445807.2

    Status: VALIDATED

    Source sequence(s)
    AABR03100234, AF115282, CB810812, CO383061
    UniProtKB/Swiss-Prot
    Q9QY78
    UniProtKB/TrEMBL
    G3V8H5
    Related
    ENSRNOP00000025851, ENSRNOT00000025851
    Conserved Domains (3) summary
    pfam12179
    Location:705742
    IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
    smart00220
    Location:15288
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14038
    Location:20309
    STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    74177233..74230809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    67214025..67266348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)