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    ACBD6 acyl-CoA binding domain containing 6 [ Homo sapiens (human) ]

    Gene ID: 84320, updated on 5-May-2013
    Official Symbol
    ACBD6provided by HGNC
    Official Full Name
    acyl-CoA binding domain containing 6provided by HGNC
    Primary source
    HGNC:23339
    See related
    Ensembl:ENSG00000135847; HPRD:12416; Vega:OTTHUMG00000035117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Location :
    1q25.1
    Sequence :
    Chromosome: 1; NC_000001.10 (180257352..180472022, complement)
    See ACBD6 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene quiescin Q6 sulfhydryl oxidase 1 Neighboring gene uncharacterized protein FLJ23867 Neighboring gene uncharacterized LOC100527964 Neighboring gene LIM homeobox 4 Neighboring gene voltage-dependent anion channel 1 pseudogene 4 Neighboring gene microRNA 3121 Neighboring gene xenotropic and polytropic retrovirus receptor 1 Neighboring gene KIAA1614

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. Oshikawa K, et al. J Proteome Res, 2012 Feb 3. PMID 22053931.
    2. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (14) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. ACBD6 is a modular protein that carries an acyl-CoA binding domain at its N terminus and two ankyrin motifs at its C terminus.
      Title: Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:124046 BioGRID:106848 APP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:124046 BioGRID:114089 IKBKG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:124046 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124046 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC2404

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    acyl-CoA-binding domain-containing protein 6
    Names
    acyl-CoA-binding domain-containing protein 6
    acyl-Coenzyme A binding domain containing 6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032360.3 → NP_115736.1  acyl-CoA-binding domain-containing protein 6

      Status: VALIDATED

      Source sequence(s)
      AA085012, AK314112, AL537685, AL561590, BU170874
      Consensus CDS
      CCDS1339.1
      UniProtKB/TrEMBL
      B2RAA8
      UniProtKB/Swiss-Prot
      Q9BR61
      Related
      ENSP00000356567, OTTHUMP00000033086, ENST00000367595, OTTHUMT00000084998
      Conserved Domains (3) summary
      cd00204
      Location:165 – 261
      Blast Score: 242
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00887
      Location:42 – 126
      Blast Score: 258
      ACBP; Acyl CoA binding protein
      pfam12796
      Location:166 – 255
      Blast Score: 228
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      180257352..180472022, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      151488279..151702640, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      186811570..187024386, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01027794.1 (11924..102203) None
    genomic ABBA01027795.1 None
    genomic ABBA01027796.1 None
    genomic AL139141.23 (64020..113808) None
    genomic AL358354.16 (2001..37478) None
    genomic AL445469.4 (101..129504) None
    genomic AMYH01001537.1 (58158..270974) None
    genomic CH471067.1 EAW91082.1
      EAW91083.1
      EAW91084.1
    mRNA AA085012.1 None
    mRNA AK314112.1 BAG36805.1
    mRNA AL537685.3 None
    mRNA AL561590.3 None
    mRNA AY606133.1 None
    mRNA BC006505.2 AAH06505.1
    mRNA BU170874.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BR61.1 GenPept UniProtKB/Swiss-Prot:Q9BR61

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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