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    NR0B2 nuclear receptor subfamily 0, group B, member 2 [ Homo sapiens ]

    Gene ID: 8431, updated on 11-May-2012
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    Summary

    Official Symbol
    NR0B2provided by HGNC
    Official Full Name
    nuclear receptor subfamily 0, group B, member 2provided by HGNC
    Primary source
    HGNC:7961
    See related
    Ensembl:ENSG00000131910; HPRD:05219; MIM:604630; Vega:OTTHUMG00000004231
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SHP; SHP1; FLJ17090
    Summary
    The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1p36.1
    Sequence :
    Chromosome: 1; NC_000001.10 (27237975..27240567, complement)
    See NR0B2 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene GPN-loop GTPase 2 Neighboring gene G patch domain containing 3 Neighboring gene nuclear distribution C homolog (A. nidulans) Neighboring gene chromosome 1 open reading frame 172

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Limited effects of bile acids and small heterodimer partner on hepatitis B virus biosynthesis in vivo. Reese VC, et al. J Virol, 2012 Mar. PMID 22171277.
    2. The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Yuk JM, et al. Nat Immunol, 2011 Jul 3. PMID 21725320.
    3. Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosis. Zhang Y, et al. J Biol Chem, 2011 Aug 26. PMID 21725089.
    4. Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes. Miao J, et al. Mol Endocrinol, 2011 Jul. PMID 21566081.
    5. Nuclear receptor SHP inhibition of Dnmt1 expression via ERRγ. Zhang Y, et al. FEBS Lett, 2011 May 6. PMID 21459093.

    See all (96) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. FXR and SHP play a limited role in modulating HBV biosynthesis.
      Title: Limited effects of bile acids and small heterodimer partner on hepatitis B virus biosynthesis in vivo.
    2. control network for Egr-1 expression through a feedback loop between SHP and HNF4alpha.
      Title: Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosis.
    3. Study provides evidence for nuclear receptor mediated regulation of Dnmt1 expression through ERRgamma and SHP crosstalk.
      Title: Nuclear receptor SHP inhibition of Dnmt1 expression via ERRγ.
    4. The activity of SHP is also increased by posttranslational methylation at Arg-57 by protein arginine methyltransferase 5 (PRMT5).
      Title: Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner.
    5. NR0B2/SHP expression level was significantly decreased in human liver cancer but not in normal liver
      Title: Systems-level analysis of gene expression data revealed NR0B2/SHP as potential tumor suppressor in human liver cancer.
    6. mutagenesis experiments whose preliminary data suggest the presence of a functional site in SHP as defined by residues Phe96, Arg138 and Arg238
      Title: Insights into the binding mode and mechanism of action of some atypical retinoids as ligands of the small heterodimer partner (SHP).
    7. genetic variations in SHP are common among human subjects; the Lys-170 residue plays a key role in controlling SHP ubiquitination and acetylation associated with SHP protein stability and repressive function
      Title: Novel polymorphisms of nuclear receptor SHP associated with functional and structural changes.
    8. Mutations of the small heterodimer partner gene is associated with obesity and type 2 diabetes.
      Title: Gender-dependent penetrance of small heterodimer partner (SHP) gene deficiency in overweight/obese Chinese pedigrees.
    9. SHP overexpression decreased the expression of Gli target genes and SHP knockdown increased the expression of these genes. The results suggest that SHP can play a negative role in Hedgehog/Gli1 signalling.
      Title: SHP (small heterodimer partner) suppresses the transcriptional activity and nuclear localization of Hedgehog signalling protein Gli1.
    10. a novel signaling pathway inhibits hepatic gluconeogenesis through HGF/AMPK/USF-1/SHP
      Title: Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes.
    Submit: New GeneRIF Correction See all (60)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Obesity, mild, early-onset

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_068804.1 NP_995582.1 NR5A2    BIND  PubMed hLRH-1 interacts with hSHP. This interaction was modelled on a demonstrated interaction between mouse LRH-1 and human SHP. 
    Q15466 P10275 AR    HPRD  PubMed  
    Q15466 Q9UHI6 DDX20    HPRD  PubMed  
    Q15466 EID1 EID1    HPRD  PubMed  
    Q15466 P03372 ESR1    HPRD  PubMed  
    Q15466 Q92731 ESR2    HPRD  PubMed  
    Q15466 P11474 ESRRA    HPRD  PubMed  
    Q15466 P62508 ESRRG    HPRD  PubMed  
    Q15466 P41235 HNF4A    HPRD  PubMed  
    Q15466 Q14541 HNF4G    HPRD  PubMed  
    Q15466 P55055 NR1H2    HPRD  PubMed  
    Q15466 Q13133 NR1H3    HPRD  PubMed  
    Q15466 Q14994 NR1I3    HPRD  PubMed  
    Q15466 O00482 NR5A2    HPRD  PubMed  
    Q15466 Q03181 PPARD    HPRD  PubMed  
    Q15466 P37231 PPARG    HPRD  PubMed  
    Q15466 P10276 RARA    HPRD  PubMed  
    Q15466 P13631 RARG    HPRD  PubMed  
    Q15466 P19793 RXRA    HPRD  PubMed  
    Q15466 P28702 RXRB    HPRD  PubMed  
    Q15466 Q13573 SNW1    HPRD  PubMed  
    Q15466 P11473 VDR    HPRD  PubMed  
    BioGRID:114012 BioGRID:106862 AR    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:114012 BioGRID:116123 EHMT2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114012 BioGRID:117243 EID1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:114012 BioGRID:108403 ESR1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:114012 BioGRID:108405 ESRRA    BioGRID  PubMed Two-hybrid 
    BioGRID:114012 BioGRID:108407 ESRRG    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114012 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114012 BioGRID:114368 HDAC3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114012 BioGRID:115330 HDAC6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114012 BioGRID:109414 HNF4A    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:114012 BioGRID:109416 HNF4G    BioGRID  PubMed Two-hybrid 
    BioGRID:114012 BioGRID:107711 KLF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114012 BioGRID:113841 NCOA3    BioGRID  PubMed Two-hybrid 
    BioGRID:114012 BioGRID:113222 NR1H2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114012 BioGRID:115373 NR1H3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:114012 BioGRID:108772 NR5A2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:114012 BioGRID:109417 ONECUT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114012 BioGRID:111117 PAX9    BioGRID  PubMed Two-hybrid 
    BioGRID:114012 BioGRID:111426 POLR2A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114012 BioGRID:111463 PPARD    BioGRID  PubMed Two-hybrid 
    BioGRID:114012 BioGRID:111464 PPARG    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114012 BioGRID:205181 Prmt5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114012 BioGRID:111849 RARA    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:114012 BioGRID:111851 RARG    BioGRID  PubMed Two-hybrid 
    BioGRID:114012 BioGRID:107308 RUNX2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114012 BioGRID:112168 RXRA    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:114012 BioGRID:112170 RXRG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114012 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114012 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114012 BioGRID:119603 SIRT6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114012 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114012 BioGRID:112479 SMARCA2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114012 BioGRID:112482 SMARCB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114012 BioGRID:112483 SMARCC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114012 BioGRID:112489 SMARCE1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114012 BioGRID:116597 SNW1    BioGRID  PubMed Two-hybrid 
    BioGRID:114012 BioGRID:112551 SP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114012 BioGRID:112923 THRA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114012 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114012 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114012 BioGRID:113264 VDR    BioGRID  PubMed Two-hybrid 
    BioGRID:114012 BioGRID:113331 XBP1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Bile secretion, organism-specific biosystem (from KEGG)
      Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
    • Bile secretion, conserved biosystem (from KEGG)
      Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
      Nuclear Receptor transcription pathway, organism-specific biosystemA classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other s...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    peroxisome proliferator activated receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    retinoid X receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    thyroid hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    androgen receptor signaling pathway RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    cholesterol metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    organ regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    nuclear receptor subfamily 0 group B member 2
    Names
    nuclear receptor subfamily 0 group B member 2
    nuclear receptor SHP
    small heterodimer partner
    orphan nuclear receptor SHP
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012143.1 RefSeqGene

      Range
      5001..7593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021969.2 → NP_068804.1  nuclear receptor subfamily 0 group B member 2

      Status: REVIEWED

      Source sequence(s)
      AA872285, AI457167, BC030207, DA930064
      Consensus CDS
      CCDS291.1
      UniProtKB/TrEMBL
      F1D8P5
      UniProtKB/Swiss-Prot
      Q15466
      Related
      ENSP00000254227, OTTHUMP00000004414, ENST00000254227, OTTHUMT00000012185
      Conserved Domains (1) summary
      cd07349
      Location:32 – 254
      Blast Score: 891
      NR_LBD_SHP; The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      27237975..27240567, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      25491554..25494146, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB058644.1 BAB68530.1
    genomic AF044316.1 None
    genomic AL356390.24 CAI13562.1
    genomic CH471059.2 EAX07781.1
    genomic L76571.1 AAC41998.1
    mRNA AA872285.1 None
    mRNA AI457167.1 None
    mRNA AK310048.1 None
    mRNA BC030207.1 AAH30207.1
    mRNA DA930064.1 None
    mRNA HQ692833.1 ADZ17344.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15466.2 GenPept UniProtKB/Swiss-Prot:Q15466
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

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