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    CASP10 caspase 10, apoptosis-related cysteine peptidase [ Homo sapiens ]

    Gene ID: 843, updated on 19-May-2012
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    Summary

    Official Symbol
    CASP10provided by HGNC
    Official Full Name
    caspase 10, apoptosis-related cysteine peptidaseprovided by HGNC
    Primary source
    HGNC:1500
    See related
    Ensembl:ENSG00000003400; HPRD:03458; MIM:601762; Vega:OTTHUMG00000132818
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCH4; ALPS2; FLICE2
    Summary
    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
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    Genomic context

    Location :
    2q33-q34
    Sequence :
    Chromosome: 2; NC_000002.11 (202047621..202094129)
    See CASP10 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene CASP8 and FADD-like apoptosis regulator Neighboring gene CFLAR antisense RNA 1 (non-protein coding) Neighboring gene RNA, U7 small nuclear 45 pseudogene Neighboring gene ribosomal protein L38 pseudogene Neighboring gene caspase 8, apoptosis-related cysteine peptidase Neighboring gene amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Downregulation of caspase-10 predicting poor survival after resection of stage II colorectal cancer. Shen XG, et al. Int J Colorectal Dis, 2011 Dec. PMID 21559821.
    2. Concerted antigen processing of a short viral antigen by human caspase-5 and -10. López D, et al. J Biol Chem, 2011 May 13. PMID 21454616.
    3. Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis. Mühlethaler-Mottet A, et al. Cell Death Dis, 2011 Mar 3. PMID 21368896.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. Casabonne D, et al. Haematologica, 2011 Feb. PMID 21048031.

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Caspase-10 expression, measured by quantitative real-time RT-PCR, is a possible prognostic factor in patients with stage II colorectal cancer.
      Title: Downregulation of caspase-10 predicting poor survival after resection of stage II colorectal cancer.
    2. Caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis.
      Title: Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis.
    3. analysis of concerted antigen processing of a short viral antigen by human caspase-5 and -10
      Title: Concerted antigen processing of a short viral antigen by human caspase-5 and -10.
    4. Prx6 modulates TRAIL signaling as a negative regulator of caspase-8 and caspase-10 in death-inducing signaling complex formation of TRAIL-resistant metastatic cancer cells.
      Title: Peroxiredoxin 6 interferes with TRAIL-induced death-inducing signaling complex formation by binding to death effector domain caspase.
    5. The CASP10 V410I polymorphism was not associated with breast or ovarian cancer risk for BRCA1 or BRCA2 mutation carriers.
      Title: Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
    6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Polymorphism in tumor necrosis factor-related apoptosis-inducing ligand receptor 1 is associated with poor viral response to interferon-based hepatitis C virus therapy in HIV/hepatitis C virus-coinfected individuals.
    7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
    8. Data show that caspase-10 is the most active caspase in apoptotic erythroid progenitors induced by 11 kDa and NS1 as well as during B19V infection.
      Title: The small 11 kDa nonstructural protein of human parvovirus B19 plays a key role in inducing apoptosis during B19 virus infection of primary erythroid progenitor cells.
    9. Somatic mutation of CASP10 is rare in colon, breast, lung, and hepatocellular carcinomas.
      Title: Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas.
    10. Data show that inhibition of NFAT3 activation by shNFAT3 significantly downregulated tumor necrosis factor (TNF)-alpha induction, its receptor TNFR1, caspase 10, caspase 3, and poly (ADP-ribose) polymerase.
      Title: Doxorubicin-mediated apoptosis in glioma cells requires NFAT3.
    Submit: New GeneRIF Correction See all (40)
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Autoimmune lymphoproliferative syndrome, type II

    Gastric cancer, somatic

    Non-Hodgkin lymphoma, somatic

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001221.2 NP_000312.1 RB1    BIND  PubMed CASP10 (caspase-10) cleaves RB-1 (hRB) at the DSID consensus site to produce the p68 form. 
    Q92851 Q9NZS9 BFAR    HPRD  PubMed  
    Q92851 P55957 BID    HPRD  PubMed  
    Q92851 Q92851 CASP10    HPRD  PubMed  
    Q92851 P31944 CASP14    HPRD  PubMed  
    Q92851 P42575 CASP2    HPRD  PubMed  
    Q92851 P42574 CASP3    HPRD  PubMed  
    Q92851 P49662 CASP4    HPRD  PubMed  
    Q92851 P55212 CASP6    HPRD  PubMed  
    Q92851 P55210 CASP7    HPRD  PubMed  
    Q92851 Q14790 CASP8    HPRD  PubMed  
    Q92851 P55211 CASP9    HPRD  PubMed  
    Q92851 Q8IX12 CCAR1    HPRD  PubMed  
    Q92851 O15519 CFLAR    HPRD  PubMed  
    Q92851 O75618 DEDD    HPRD  PubMed  
    Q92851 Q8WXF8 DEDD2    HPRD  PubMed  
    Q92851 P15924 DSP    HPRD  PubMed  
    Q92851 Q13158 FADD    HPRD  PubMed  
    Q92851 P24928 POLR2A    HPRD  PubMed  
    Q92851 P06400 RB1    HPRD  PubMed  
    Q92851 Q8N488 RYBP    HPRD  PubMed  
    Q92851 P19438 TNFRSF1A    HPRD  PubMed  
    Q92851 Q13077 TRAF1    HPRD  PubMed  
    BioGRID:107293 BioGRID:35900 AIF1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:107293 BioGRID:106889 ARHGDIA    BioGRID  PubMed Co-purification 
    BioGRID:107293 BioGRID:107106 BID    BioGRID  PubMed Co-purification 
    BioGRID:107293 BioGRID:107284 CASP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107293 BioGRID:107293 CASP10    BioGRID  PubMed Biochemical Activity 
    BioGRID:107293 BioGRID:117116 CASP14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107293 BioGRID:107285 CASP2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107293 BioGRID:107286 CASP3    BioGRID  PubMed Biochemical Activity 
    BioGRID:107293 BioGRID:107287 CASP4    BioGRID  PubMed Biochemical Activity 
    BioGRID:107293 BioGRID:107289 CASP6    BioGRID  PubMed Biochemical Activity 
    BioGRID:107293 BioGRID:107290 CASP7    BioGRID  PubMed Biochemical Activity 
    BioGRID:107293 BioGRID:107291 CASP8    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-purification 
    BioGRID:107293 BioGRID:107292 CASP9    BioGRID  PubMed Biochemical Activity 
    BioGRID:107293 BioGRID:114364 CFLAR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107293 BioGRID:114627 DEDD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107293 BioGRID:127838 DEDD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107293 BioGRID:113271 EZR    BioGRID  PubMed Co-purification 
    BioGRID:107293 BioGRID:114302 FADD    BioGRID  PubMed Affinity Capture-Western; Co-purification; FRET; Reconstituted Complex 
    BioGRID:107293 BioGRID:106851 FAS    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:107293 BioGRID:106852 FASLG    BioGRID  PubMed Co-purification 
    BioGRID:107293 BioGRID:114487 MAP3K14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107293 BioGRID:111585 MAPK8    BioGRID  PubMed Co-purification 
    BioGRID:107293 BioGRID:34595 MCA1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:107293 BioGRID:110584 MSN    BioGRID  PubMed Co-purification 
    BioGRID:107293 BioGRID:106880 RHOA    BioGRID  PubMed Co-purification 
    BioGRID:107293 BioGRID:114274 RIPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107293 BioGRID:116997 RYBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107293 BioGRID:114325 TNFRSF10A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107293 BioGRID:114323 TNFRSF10B    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:107293 BioGRID:112986 TNFRSF1A    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:107293 BioGRID:113037 TRAF1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107293 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • Death Receptor Signalling, organism-specific biosystem (from REACTOME)
      Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Extrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Extrinsic Pathway for Apoptosis, organism-specific biosystemKnown as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, ...
    • FAS (CD95) signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FAS (CD95) signaling pathway, organism-specific biosystem
      FAS (CD95) signaling pathway
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • FasL/ CD95L signaling, organism-specific biosystem (from REACTOME)
      FasL/ CD95L signaling, organism-specific biosystemThe Fas family of cell surface receptors initiate the apototic pathway through interaction with the external ligand, FasL. The cytoplasmic domain of Fas interacts with a number of molecules in the t...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, organism-specific biosystem (from REACTOME)
      NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, organism-specific biosystemFas-associateddeathdomain (FADD) and receptor interacting protein 1 (RIP1) are death domain containing molecules that interact with the C-terminal portion of IPS-1 and induce NF-kB through interactio...
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • TRAIL signaling, organism-specific biosystem (from REACTOME)
      TRAIL signaling, organism-specific biosystemTumor necrosis factor-related apoptosis-inducing ligand or Apo 2 ligand (TRAIL/Apo2L) is a member of the tumor necrosis factor (TNF) family. This group of apoptosis induction pathways all work throug...
    • TRAIL signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      TRAIL signaling pathway, organism-specific biosystem
      TRAIL signaling pathway
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    induction of apoptosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    induction of apoptosis by extracellular signals TAS
    Traceable Author Statement
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of I-kappaB kinase/NF-kappaB cascade RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    caspase-10
    Names
    caspase-10
    CASP-10
    FADD-like ICE2
    apoptotic protease MCH-4
    ICE-like apoptotic protease 4
    interleukin-1B-converting enzyme 2
    caspase 10, apoptosis-related cysteine protease
    FAS-associated death domain protein interleukin-1B-converting enzyme 2
    NP_001193453.1
    NP_001193471.1
    NP_001221.2
    NP_116756.2
    NP_116758.1
    NP_116759.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007265.1 RefSeqGene

      Range
      4767..51275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_33

    mRNA and Protein(s)

    1. NM_001206524.1 → NP_001193453.1  caspase-10 isoform 6 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two in-frame coding exons compared to variant 1. This results in a shorter isoform (6) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AC007283, BC042844, DA456072, U60519
      Consensus CDS
      CCDS56159.1
      UniProtKB/Swiss-Prot
      Q92851
      Related
      ENSP00000314599, OTTHUMP00000206550, ENST00000313728, OTTHUMT00000336848
      Conserved Domains (3) summary
      cd00032
      Location:241 – 447
      Blast Score: 661
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08814
      Location:112 – 190
      Blast Score: 324
      DED_Caspase_10_repeat2; Death Effector Domain, repeat 2, of Caspase-10
      cl14633
      Location:18 – 99
      Blast Score: 343
      DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains

    2. NM_001206542.1 → NP_001193471.1  caspase-10 isoform 5 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two in-frame coding exons and contains an alternate 3' terminal exon compared to variant 1. This results in a shorter isoform (5) missing an internal protein segment and with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC007283, AJ487679, BC042844, BX089180, DA456072
      Consensus CDS
      CCDS56160.1
      UniProtKB/Swiss-Prot
      Q92851
      Related
      ENSP00000396835, OTTHUMP00000206551, ENST00000448480, OTTHUMT00000336849
      Conserved Domains (3) summary
      cd00032
      Location:232 – 454
      Blast Score: 673
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08814
      Location:112 – 190
      Blast Score: 329
      DED_Caspase_10_repeat2; Death Effector Domain, repeat 2, of Caspase-10
      cl14633
      Location:18 – 99
      Blast Score: 352
      DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains

    3. NM_001230.4 → NP_001221.2  caspase-10 isoform 3 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two in-frame coding exons compared to variant 1. This results in a shorter isoform (3, also known as Mch4 and caspase-10/a) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AC007283, BC042844, DA456072, U60519
      Consensus CDS
      CCDS2339.1
      UniProtKB/Swiss-Prot
      Q92851
      Related
      ENSP00000237865, OTTHUMP00000163714, ENST00000346817, OTTHUMT00000256274
      Conserved Domains (3) summary
      cd00032
      Location:232 – 471
      Blast Score: 770
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08814
      Location:112 – 190
      Blast Score: 326
      DED_Caspase_10_repeat2; Death Effector Domain, repeat 2, of Caspase-10
      cl14633
      Location:18 – 99
      Blast Score: 345
      DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains

    4. NM_032974.4 → NP_116756.2  caspase-10 isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon compared to variant 1, and encodes an isoform (2, also known as FLICE2 and caspase-10/b) that has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC007283, BC042844, BX089180, DA456072
      Consensus CDS
      CCDS2338.1
      UniProtKB/Swiss-Prot
      Q92851
      Related
      ENSP00000272879, OTTHUMP00000163713, ENST00000272879, OTTHUMT00000256273
      Conserved Domains (3) summary
      cd00032
      Location:275 – 497
      Blast Score: 679
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08341
      Location:18 – 99
      Blast Score: 358
      DED_Caspase_10_repeat1; Death effector domain, repeat 1, of Caspase-10
      cd08814
      Location:112 – 190
      Blast Score: 335
      DED_Caspase_10_repeat2; Death Effector Domain, repeat 2, of Caspase-10

    5. NM_032976.3 → NP_116758.1  caspase-10 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal coding exon compared to variant 1. This results in a frame-shift and premature translation termination, rendering this transcript a candidate for nonsense-mediated mRNA decay (NMD). However, the encoded truncated isoform (4, also known as caspase-10/c) is represented, as there is published report (PMID:10187817) that shows that although this isoform lacks proteolytic activity in vitro, it efficiently induces the formation of perinuclear filamentous structures and cell death in vivo.
      Source sequence(s)
      AC007283, BC042844, DA456072, U60519
      UniProtKB/Swiss-Prot
      Q92851
      Related
      ENSP00000353250, ENST00000360132
      Conserved Domains (2) summary
      cd08814
      Location:112 – 190
      Blast Score: 306
      DED_Caspase_10_repeat2; Death Effector Domain, repeat 2, of Caspase-10
      cl14633
      Location:18 – 99
      Blast Score: 330
      DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains

    6. NM_032977.3 → NP_116759.2  caspase-10 isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1, also known as caspase-10/d).
      Source sequence(s)
      AC007283, BC042844, DA456072, U60519
      Consensus CDS
      CCDS2340.1
      UniProtKB/Swiss-Prot
      Q92851
      Related
      ENSP00000286186, OTTHUMP00000163712, ENST00000286186, OTTHUMT00000256272
      Conserved Domains (3) summary
      cd00032
      Location:275 – 514
      Blast Score: 777
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08814
      Location:112 – 190
      Blast Score: 332
      DED_Caspase_10_repeat2; Death Effector Domain, repeat 2, of Caspase-10
      cl14633
      Location:18 – 99
      Blast Score: 351
      DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      202047621..202094129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      193898993..193945498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB038979.2 BAB32553.1
      BAB32554.1
    genomic AC007283.3 AAY24291.1
    genomic CH471063.1 EAW70247.1
      EAW70248.1
      EAW70249.1
      EAW70250.1
      EAW70251.1
    genomic EF050529.1 ABJ53426.1
    mRNA AF111344.1 AAD28402.1
    mRNA AF111345.1 AAD28403.1
    mRNA AI696103.1 None
    mRNA AJ487678.1 CAD32371.1
    mRNA AJ487679.1 CAD32372.1
    mRNA AK225475.1 None
    mRNA AK304859.1 BAG65597.1
    mRNA AK310746.1 None
    mRNA AY690601.3 AAU00989.1
    mRNA BC042844.1 AAH42844.1
    mRNA BX089180.1 None
    mRNA DA456072.1 None
    mRNA U60519.1 AAC50644.1
    mRNA U86214.1 AAB46730.1
    other-genetic JF432405.1 ADZ15622.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68HC0 GenPept UniProtKB/TrEMBL:Q68HC0
    Q92851.3 GenPept UniProtKB/Swiss-Prot:Q92851
    Help top of page

    Additional Links

    Additional Links

    • Epigenomics
    • MIM 601762
    • CASP10base: Mutation registry for Autoimmune lymphoproliferative syndrome, type II (ALPS2) CASP10base/
    • PharmGKB PA26084
    • Catalogue of Somatic Mutations in Cancer (COSMIC) CASP10
    • GeneTests for MIM: 601762
    • CCHMC - Human Genetics Mutation Database CASP10
    • Resource of Asian Primary Immunodeficiency Diseases (RAPID) AGID_26
    • UCSC UCSC
    • UniGene Hs.5353

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