My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    STK24 serine/threonine kinase 24 [ Homo sapiens ]

    Gene ID: 8428, updated on 9-Feb-2012
    Help top of page

    Summary

    Official Symbol
    STK24provided by HGNC
    Official Full Name
    serine/threonine kinase 24provided by HGNC
    Primary source
    HGNC:11403
    Locus tag
    RP11-111L24.5
    See related
    Ensembl:ENSG00000102572; HPRD:10385; MIM:604984; Vega:OTTHUMG00000017250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MST3; STK3; MST3B; STE20
    Summary
    The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 [PubMed 10644707]).[supplied by OMIM, Mar 2008]
    Help top of page

    Genomic context

    Location :
    13q31.2-q32.3
    Sequence :
    Chromosome: 13; NC_000013.10 (99102455..99229396, complement)
    See STK24 in Epigenomics, MapViewer

    Chromosome 13 - NC_000013.10Genomic Context describing neighboring genes Neighboring gene FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) Neighboring gene microRNA 3170 Neighboring gene FARP1 intronic transcript 1 (non-protein coding) Neighboring gene nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 4 Neighboring gene cytochrome c, somatic pseudogene 35

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Mammalian Ste20-like protein kinase 3 plays a role in hypoxia-induced apoptosis of trophoblast cell line 3A-sub-E. Wu HY, et al. Int J Biochem Cell Biol, 2011 May. PMID 21277991.
    2. Joint influence of small-effect genetic variants on human longevity. Yashin AI, et al. Aging (Albany NY), 2010 Sep. PMID 20834067.
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    4. Structures of human MST3 kinase in complex with adenine, ADP and Mn2+. Ko TP, et al. Acta Crystallogr D Biol Crystallogr, 2010 Feb. PMID 20124694.
    5. Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways. Lorber B, et al. Nat Neurosci, 2009 Nov. PMID 19855390.

    See all (24) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Mst3 is up-regulated and plays an important role in hypoxia-induced apoptosis of human trophoblasts.
      Title: Mammalian Ste20-like protein kinase 3 plays a role in hypoxia-induced apoptosis of trophoblast cell line 3A-sub-E.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. five crystal structures of the catalytic domain of MST3 are presented, including a complex with ADP and manganese, a unique cofactor preferred by the enzyme, and a complex with adenine.
      Title: Structures of human MST3 kinase in complex with adenine, ADP and Mn2+.
    4. The mammalian sterile 20-like serine/threonine protein kinase 3 (Mst3) plays an essential role in the staurosporine-induced apoptosis of HeLa cells.
      Title: Mammalian Ste20-like protein kinase 3 induces a caspase-independent apoptotic pathway.
    5. Our results reveal that H2O2-induced MST3-mediated cell death involves suppressing both a JNK survival pathway and up-regulation of HO-1.
      Title: Mammalian sterile 20-like kinase 3 (MST3) mediates oxidative-stress-induced cell death by modulating JNK activation.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.
    7. study demonstrated the essential role of Mst3, a human Ste20-like protein kinase, in the oxidative stress-induced apoptosis of trophoblasts of term placenta in normal spontaneous delivery
      Title: Mammalian Ste20-like protein kinase 3 mediates trophoblast apoptosis in spontaneous delivery.
    8. MST3 inhibits cell migration in a fashion dependent on autophosphorylation and may regulate paxillin phosphorylation through tyrosine phosphatase PTP-PEST
      Title: Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST.
    9. Activation of NDR2 is a multistep process involving phosphorylation of the hydrophobic motif site Thr444/2 by MST3.
      Title: Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3.
    10. Proteolytic activation of Mst3 by caspases.
      Title: Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis.
    Submit: New GeneRIF Correction See all (11)
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Joint influence of small-effect genetic variants on human longevity.

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9Y6E0 P42574 CASP3    HPRD  PubMed  
    Q9Y6E0 P55210 CASP7    HPRD  PubMed  
    Q9Y6E0 Q14790 CASP8    HPRD  PubMed  
    Q9Y6E0 Q9BUL8 PDCD10    HPRD  PubMed  
    Q9Y6E0 Q9Y2H1 STK38L    HPRD  PubMed  
    BioGRID:114011 BioGRID:106844 APOD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:115827 CCT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:113054 CCT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:115826 CCT4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:116603 CCT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:107346 CCT6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:115825 CCT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:115933 CCT8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:123842 CTTNBP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:121000 CTTNBP2NL    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114011 BioGRID:108021 DDX5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:108166 DSP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:108469 FABP5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:124497 FAM40A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:121534 FAM40B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:117566 FGFR1OP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:115237 G3BP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:128670 HNRNPA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:109430 HNRNPH3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:121492 JPH3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:110333 MCC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:117369 MOB4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:116400 PDCD10    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:114011 BioGRID:115332 PDCD6IP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:111508 PPP2CB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:111510 PPP2R1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:111511 PPP2R1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:123136 SIKE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:113620 SLMAP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:115757 STK25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:112674 STRN    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114011 BioGRID:118999 STRN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:118941 STRN4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:115755 SYNCRIP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:112810 TCP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114011 BioGRID:123249 TRAF3IP3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114011 BioGRID:115177 ZBTB24    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    cellular component disassembly involved in apoptosis TAS
    Traceable Author Statement
    more info
    		  
    induction of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    induction of apoptosis by oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    serine/threonine-protein kinase 24
    Names
    serine/threonine-protein kinase 24
    STE20-like kinase 3
    STE20-like kinase MST3
    sterile 20-like kinase 3
    mammalian STE20-like protein kinase 3
    serine/threonine kinase 24 (STE20 homolog, yeast)
    NP_001027467.2
    NP_003567.2
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032296.2 → NP_001027467.2  serine/threonine-protein kinase 24 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for the 5' UTR and 5' CDS, compared to variant 1. The resulting protein (isoform b) has a distinct and shorter N-terminus when it is compared to isoform a.
      Source sequence(s)
      AL137249, AL356423, BC035578, BC065378, DB479387
      Consensus CDS
      CCDS32001.1
      UniProtKB/TrEMBL
      Q5U0E6
      UniProtKB/TrEMBL
      Q6P0Y1
      UniProtKB/Swiss-Prot
      Q9Y6E0
      Related
      ENSP00000380651, OTTHUMP00000018592, ENST00000397517, OTTHUMT00000045548
      Conserved Domains (3) summary
      cd06609
      Location:22 – 295
      Blast Score: 1331
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Protein Serine/Threonine Kinases
      pfam06840
      Location:364 – 417
      Blast Score: 83
      DUF1241; Protein of unknown function (DUF1241)
      smart00220
      Location:24 – 274
      Blast Score: 723
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    2. NM_003576.3 → NP_003567.2  serine/threonine-protein kinase 24 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform a).
      Source sequence(s)
      AF083420, AL137249, DA386652
      Consensus CDS
      CCDS9488.1
      UniProtKB/Swiss-Prot
      Q9Y6E0
      Related
      ENSP00000365730, OTTHUMP00000018593, ENST00000376547, OTTHUMT00000045549
      Conserved Domains (3) summary
      cd06609
      Location:34 – 307
      Blast Score: 1332
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Protein Serine/Threonine Kinases
      pfam06840
      Location:376 – 429
      Blast Score: 83
      DUF1241; Protein of unknown function (DUF1241)
      smart00220
      Location:36 – 286
      Blast Score: 725
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000013.10 Reference GRCh37.p5 Primary Assembly

      Range
      99102455..99229396, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000145.1 Alternate HuRef

      Range
      79700446..79772602, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL137249.29 CAI39452.1
      CAI39453.1
      CAI39455.1
      CAI39456.1
      CAI39457.1
    genomic AL137249.29 CAI39452.1
      CAI39453.1
      CAI39455.1
      CAI39456.1
      CAI39457.1
    genomic AL356423.15 CAI13113.1
      CAI13114.1
      CAI13115.1
    genomic CH471085.1 EAX08985.1
      EAX08986.1
      EAX08987.1
    mRNA AF024636.1 AAB82560.1
    mRNA AF083420.1 AAD42039.1
    mRNA AF339826.1 None
    mRNA AK297583.1 BAG59972.1
    mRNA AK299140.1 BAG61192.1
    mRNA BC035578.1 AAH35578.1
    mRNA BC065378.1 AAH65378.1
    mRNA BT019619.1 AAV38425.1
    mRNA CR542227.1 CAG47023.1
    mRNA DA386652.1 None
    mRNA DB479387.1 None
    other-genetic DQ890912.2 ABM81838.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q5JV99 GenPept UniProtKB/TrEMBL:Q5JV99
    Q5U0E6 GenPept UniProtKB/TrEMBL:Q5U0E6
    Q6FG81 GenPept UniProtKB/TrEMBL:Q6FG81
    Q6P0Y1 GenPept UniProtKB/TrEMBL:Q6P0Y1
    Q9Y6E0.1 GenPept UniProtKB/Swiss-Prot:Q9Y6E0
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...