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TRAF7 TNF receptor associated factor 7 [ Homo sapiens (human) ]

Gene ID: 84231, updated on 26-May-2016
Official Symbol
TRAF7provided by HGNC
Official Full Name
TNF receptor associated factor 7provided by HGNC
Primary source
HGNC:HGNC:20456
See related
Ensembl:ENSG00000131653 HPRD:06977; MIM:606692; Vega:OTTHUMG00000128826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RFWD1; RNF119
Summary
Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]
Orthologs
Location:
16p13.3
Exon count:
21
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (2155753..2178129)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2205763..2228130)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RAB26, member RAS oncogene family Neighboring gene small nucleolar RNA, C/D box 60 Neighboring gene small nucleolar RNA host gene 19 Neighboring gene CASK interacting protein 1 Neighboring gene MTOR associated protein, LST8 homolog Neighboring gene BRICHOS domain containing 5 Neighboring gene phosphoglycolate phosphatase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC7807, DKFZp586I021

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
activation of MAPKKK activity IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic, membrane-bounded vesicle IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
E3 ubiquitin-protein ligase TRAF7
Names
RING finger and WD repeat-containing protein 1
RING finger protein 119
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
ring finger and WD repeat domain 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032271.2NP_115647.2  E3 ubiquitin-protein ligase TRAF7

    See identical proteins and their annotated locations for NP_115647.2

    Status: VALIDATED

    Source sequence(s)
    AK090624, AL136921, AW245178
    Consensus CDS
    CCDS10461.1
    UniProtKB/Swiss-Prot
    Q6Q0C0
    UniProtKB/TrEMBL
    B3KQY7
    Related
    ENSP00000318944, OTTHUMP00000159043, ENST00000326181, OTTHUMT00000250762
    Conserved Domains (5) summary
    cl17044
    Location:282322
    DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
    COG2319
    Location:380668
    WD40; WD40 repeat [General function prediction only]
    cd00162
    Location:130163
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd00200
    Location:388668
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam02176
    Location:222266
    zf-TRAF; TRAF-type zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    2155753..2178129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255627.3XP_005255684.1  

    Conserved Domains (4) summary
    cl17044
    Location:280320
    DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
    COG2319
    Location:378666
    WD40; WD40 repeat [General function prediction only]
    cd00162
    Location:130163
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd00200
    Location:386666
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_011522700.1XP_011521002.1  

    See identical proteins and their annotated locations for XP_011521002.1

    Conserved Domains (5) summary
    cl17044
    Location:253293
    DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
    COG2319
    Location:351639
    WD40; WD40 repeat [General function prediction only]
    cd00162
    Location:101134
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd00200
    Location:359639
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam02176
    Location:193237
    zf-TRAF; TRAF-type zinc finger

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    2205774..2228103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_206835.1: Suppressed sequence

    Description
    NM_206835.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.